Sex detemination in the Drosophila germline is dictated by the sexual identity of the surrounding soma

Genetics

Volumn 155, Issue 4, 2000, Pages 1741-1756

  Waterbury, J A ^a   Horabin, J I ^b   Bopp, D ^c   Schedl, Paul ^a  

^a PRINCETON UNIVERSITY   (United States)

^b UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^c UNIVERSITY OF ZURICH   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; CONTROLLED STUDY; DROSOPHILA; FEMALE; FEMINIZATION; GENDER IDENTITY; GENE CONTROL; GENE EXPRESSION; GENE INDUCTION; GENE MUTATION; GERM LINE; MALE; MARKER GENE; NONHUMAN; PRIORITY JOURNAL; SEX DETERMINATION; SIGNAL TRANSDUCTION; SOMATIC CELL GENETICS; ALLELE; ANIMAL; BIOLOGICAL MODEL; FLUORESCENT ANTIBODY TECHNIQUE; GENDER AND SEX; GENETICS; GERM CELL; METABOLISM; MUTAGENESIS; PHYSIOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA SPLICING; TRANSGENIC ANIMAL; WESTERN BLOTTING; X CHROMOSOME;

ANIMALIA; ARACHNIDA; HEXAPODA;

BETA GALACTOSIDASE; COMPLEMENTARY DNA; DNA BINDING PROTEIN; DOUBLESEX PROTEIN, DROSOPHILA; DROSOPHILA PROTEIN; INSECT PROTEIN; NUCLEAR PROTEIN; RIBONUCLEOPROTEIN; TRA2 PROTEIN, DROSOPHILA; TRANSFORMER PROTEIN, DROSOPHILA;

ALLELES; ANIMALS; ANIMALS, GENETICALLY MODIFIED; BETA-GALACTOSIDASE; BLOTTING, WESTERN; DNA, COMPLEMENTARY; DNA-BINDING PROTEINS; DROSOPHILA; DROSOPHILA PROTEINS; FEMALE; FLUORESCENT ANTIBODY TECHNIQUE; GERM CELLS; INSECT PROTEINS; MALE; MODELS, GENETIC; MUTAGENESIS; NUCLEAR PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RIBONUCLEOPROTEINS; RNA SPLICING; SEX DETERMINATION (GENETICS); X CHROMOSOME;

EID: 0033624528     PISSN: 00166731     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (55)

1. Integrating sex- and tissue-specific regulation within a single Drosophila enhancer
2. Genetic and molecular analysis of the autosomal component of the primary sex determination signal of Drosophila melanogaster
3. Sex-lethal, a Drosophila sex determination switch gene, exhibits sex-specific RNA splicing and sequence similarity to RNA binding proteins
4. Positive autoregulation of sex-lethal by alternative splicing maintains the female determined state in Drosophila
5. P-element-mediated enhancer detection: A versatile method to study development in Drosophila
6. Transposon insertions causing constitutive Sex-lethal activity in Dwsophila melanogaster affect Sxl sex-specific transcript splicing
7. Expression of the Sex-lethal gene is controlled at multiple levels during Drosophila oogenesis
8. Drosophila doublesex gene controls somatic sexual differentiation by producing alternatively spliced mRNAs encoding related sex-specific polypeptides
9. Two closely linked mutations in Drosophila melanogaster that are lethal to opposite sexes and interact with daughter-less
10. Autoregulation functioning of a Drosophila gene product that establishes and maintains the sexually determined state
11. Vive la difference: Males vs females in flies vs worms
12. The Drosophila Doublesex proteins share a novel zinc finger related DNA binding domain
13. A bZIP protein, sisterless-a, collaborates with bHLH transcription factors early in Drosophila development to determine sex
14. The multivulva phenotype of certain Caenorhabditis elegans mutants results from defects in two functionally redundant pathways
15. Probing spermatogenesis in Drosophila with P-element enhancer detectors
16. Sex determination in the germ line of Drosophila melanogaster. Activation of the gene Sex-lethal
17. Induction of female Sex-lethal RNA splicing in male germ cells: Implications for Drosophila germline sex determination
18. Genetic control of sex determination in the germ line and soma of the housefly, Musca domestica
19. Regulatory and functional interactions between the somatic sex regulatory gene transformer and the germline genes ovo and ovarian tumor
20. Regulated splicing of the Drosophila Sex-lethal male exon involves a blockage mechanism
21. Selection and maintenance of sexual identity in the Drosophila germline
22. Genetic regulation of entry into meiosis in Caenorhabditis elegans
23. The primary sex determination signal of Drosophila acts at the level of transcription
24. Complementation between alleles at the ovarian tumor locus of Drosophila melanogaster
25. The Drosophila orb RNA-binding protein is required for the formation of the egg chamber and establishment of polarity
26. Is sex determination in germ line and soma controlled by separate genetic mechanisms?
27. A molecular analysis of transformer, a gene in Drosophila melanogaster that controls female sexual differentiation
28. Ectopic expression of the female transformer gene product leads to female differentiation of chromosomally male Drosophila
29. Germ cells and germ cell sex
30. The control of alternative splicing at genes regulating sexual differentiation in D. melanogaster
31. The somatic sex determines the requirement for ovarian tumor gene activity in the proliferation of the Drosophila germline
32. Sex determination in the germ line of Drosophila depends on genetic signals and inductive somatic factors
33. The ovo locus is required for sex-specific germ line maintenance in Drosophila
34. Genetic evidence that the sans fille locus is involved in Drosophila sex determination
35. Genetic evidence that the ovo locus is involved in Drosophila germ line sex determination
36. Sex-lethal, master and slave: A hierarchy of germ-line sex determination in Drosophila
37. Function of Drosophila ovo+ in germ-line sex determination depends on X-chromosome number
38. The role of the ovarian tumor locus in Drosophila melanogaster germ line sex determination
39. A sex-specific number of germ cells in embryonic gonads of Drosophila
40. Developmental analysis of the ovarian tumor gene during Drosophila oogenesis
41. The Drosophila female-specific sex-determination gene, Sex-lethal, has stage-, tissue-, and sex-specific RNAs suggesting multiple modes of regulation
42. The complex set of late transcripts from the Drosophila sex determination gene Sex-lethal encodes multiple related polypeptides
43. Autosomal mutations that interfere with sex determination in somatic cells of Drosophila have no direct effect on the germline
44. Normal female germ cell differentiation requires the female X chromosome to autosome ratio and expression of sex-lethal in Drosophila melanogaster
45. Female germ cells of Drosophila require zygotic ovo and otu product for survival in larvae and pupae respectively
46. Sex determination in Drosophila: Sis-b, a major numerator element of the X:A ratio in the soma, does not contribute to the X:A ratio in the germ line
47. Sex determination of the Drosophila germ line: Tra and dsx control somatic inductive signals
48. Cell-autonomous and inductive signals can determine the sex of the germ line of Drosophila by regulating the gene Sxl
49. Analysis of sex determination in monogenic blowfly Chrysomya rufifacies by pole cell transplantation
50. A new sex-transforming gene on the second chromosome of Drosophila melanogaster
51. Analysis of the Doublesex female protein in Drosophila melanogaster. Role in sexual differentiation and behavior and dependence on Intersex
52. Translational repressor bruno plays multiple roles in development and is widely conserved
53. The germline: Familiar and newly uncovered properties
54. An N-terminal truncation uncouples the sex-transforming and dosage compensation functions of Sex-lethal