Dopamine D2 receptor inhibition of adenylyl cyclase is abolished by acute ethanol but restored after chronic ethanol exposure (Tolerance)

Journal of Pharmacology and Experimental Therapeutics

Volumn 298, Issue 2, 2001, Pages 833-839

  Yao, Lina ^a,b   Asai, Kiyofumi ^d   Jiang, Zhan ^a   Ishii, Akira ^e   Fan, Peidong ^a   Gordon, Adrienne S ^a,b,c   Diamond, Ivan ^a,b,c,f  

^a UNIVERSITY OF CALIFORNIA SAN FRANCISCO   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d NAGOYA CITY UNIV MEDICAL SCHOOL   (Japan)

^e NAGOYA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^f NONE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENYLATE CYCLASE; ALCOHOL; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE INHIBITOR; DOPAMINE 2 RECEPTOR; DOPAMINE 2 RECEPTOR BLOCKING AGENT; DOPAMINE 2 RECEPTOR STIMULATING AGENT; GUANOSINE 5' O (3 THIOTRIPHOSPHATE); MEMBRANE RECEPTOR; PROPYLNORAPOMORPHINE;

ALCOHOL TOLERANCE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL MEMBRANE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; GENETIC TRANSFECTION; ISOMER; LONG TERM EXPOSURE; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR AFFINITY;

ADENYLATE CYCLASE; CELL LINE; CENTRAL NERVOUS SYSTEM DEPRESSANTS; CYCLIC AMP-DEPENDENT PROTEIN KINASES; DRUG TOLERANCE; ENZYME INHIBITORS; ETHANOL; GTP-BINDING PROTEINS; HUMANS; RECEPTOR, MUSCARINIC M4; RECEPTORS, DOPAMINE D2; RECEPTORS, MUSCARINIC; RECEPTORS, OPIOID, DELTA;

EID: 0034922862     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (40)

1. Varying effects of ethanol on transfected cell lines
2. Ethanol modulation of opiate receptors in cultured neural cells
3. Activation of cyclic AMP-dependent protein kinase reverses tolerance of a nucleoside transporter to ethanol
4. Cellular and molecular neuroscience of alcoholism
5. Basal and adenosine receptor-stimulated levels of cAMP are reduced in lymphocytes from alcoholic patients
6. Ethanol causes translocation of cAMP-dependent protein kinase catalytic subunit to the nucleus
7. Differential glycosylation and intracellular trafficking for the long and short isoforms of the D2 dopamine receptor
8. Beta adrenergic sensitization of gamma-aminobutyric acid receptors to ethanol involves a cyclic AMP/protein kinase A second-messenger mechanism
9. Ethanol regulation of adenosine receptor-stimulated cAMP levels in a clonal neural cell line: An in vitro model of cellular tolerance to ethanol
10. Ethanol acts synergistically with a dopamine agonist to cause translocation of PKC
11. Compartmentation of receptors and guanine nucleotide-binding proteins in NG108-15 cells: Lack of cross-talk in agonist binding among the alpha 2-adrenergic, muscarinic, and opiate receptors
12. Alcohol self-administration: Further examination of the role of dopamine receptors in the nucleus accumbens
13. 125I]epidepride binding to dopamine D2 receptors in basal ganglia and cortex of human brain
14. Drug abuse: Hedonic homeostatic dysregulation
15. 2+ currents in rat anterior pituitary cells
16. Two sites in the third inner loop of the dopamine D2 receptor are involved in functional G protein-mediated coupling to adenylate cyclase
17. The alpha 2B adrenergic receptor of undifferentiated neuroblastoma x glioma hybrid NG108-15 cells, interacts directly with the guanine nucleotide binding protein, Gi2
18. Platelet adenylyl cyclase activity as a trait marker of alcohol dependence
19. Molecular biology of alcohol dependence
20. Binding characteristics, of the muscarinic receptor subtype of the NG108-15 cell line
21. Differential regulation of cAMP-mediated gene transcription by m1 and m4 muscarinic acetylcholine receptors. Preferential coupling of m4 receptors to Gi alpha-2
22. Identification and characterization of D1 and D2 dopamine receptors in cultured neuroblastoma and retinoblastoma clonal cell lines
23. Ethanol intoxication in Drosophila: Genetic and pharmacological evidence for regulation by the cAMP signaling pathway
24. Cycloheximide potentiation of prostaglandin E1-and cholera toxin-stimulated cyclic AMP accumulation in NG108-CC15 neuroblastoma-glioma hybrid cells
25. Adenylyl cyclase interaction with the D2 dopamine receptor family: Differential coupling to Gi, Gz, and Gs
26. Dopamine D2L receptor couples to G alpha i2 and G alpha i3 but not G alpha i1, leading to the inhibition of adenylate cyclase in transfected cell lines
27. Alcohol preference and sensitivity are markedly reduced in mice lacking dopamine D2 receptors
28. Dopamine activation of the arachidonic acid cascade as a basis for D1/D2 receptor synergism
29. The delta-opioid receptor in neuroblastoma x glioma NG 108-15 hybrid cells is strongly precoupled to a G-protein
30. Clinical characteristics of alcoholism in alcohol-dependent subjects with and without a history of alcohol treatment
31. Drug addiction: Bad habits add up
32. The neural basis of drug craving: An incentive-sensitization theory of addiction
33. Identification of three separate guanine nucleotide binding proteins that interact with the delta-opioid receptor in NG108-15 neuroblastoma x glioma hybrid cells
34. Delta-opioid supraspinal antinociception in mice is mediated by Gi3 transducer proteins
35. Involvement of cAMP-dependent protein kinase in the nucleus accumbens in cocaine self-administration and relapse of cocaine-seeking behavior
36. The D2 dopamine receptor isoforms signal through distinct Gi alpha proteins to inhibit adenylyl cyclase. A study with site-directed mutant Gi alpha proteins
37. High ethanol consumption and low sensitivity to ethanol-induced sedation in protein kinase A-mutant mice
38. Comparison of the ligand binding and signaling properties of human dopamine D2 and D3 receptors in Chinese hamster ovary cells
39. Expression of a dopamine D2 receptor-activated K+ channel on identified striatopallidal and striatonigral neurons
40. Monovalent cation and amiloride analog modulation of adrenergic ligand binding to the unglycosylated alpha 2B-adrenergic receptor subtype