Activation of cyclic AMP-dependent protein kinase reverses tolerance of a nucleoside transporter to ethanol

Journal of Pharmacology and Experimental Therapeutics

Volumn 276, Issue 2, 1996, Pages 365-369

  Coe, Imogen R ^a   Dohrman, Douglas P ^a   Constantinescu, Anastasia ^a   Diamond, Ivan ^a,b,c   Gordon, Adrienne S ^a,b,c,d  

^a UNIVERSITY OF CALIFORNIA SAN FRANCISCO   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d SAN FRANCISCO GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE; ALCOHOL; CARRIER PROTEIN; CYCLIC AMP DEPENDENT PROTEIN KINASE; MEMBRANE PROTEIN; NUCLEOSIDE TRANSPORTER; PHOSPHOPROTEIN PHOSPHATASE; PROTEIN KINASE C;

ARTICLE; CELL CULTURE; DRUG EFFECT; DRUG TOLERANCE; METABOLISM; PHOSPHORYLATION; PHYSIOLOGY;

ADENOSINE; CARRIER PROTEINS; CYCLIC AMP-DEPENDENT PROTEIN KINASES; DRUG TOLERANCE; ETHANOL; MEMBRANE PROTEINS; NUCLEOSIDE TRANSPORT PROTEINS; PHOSPHOPROTEIN PHOSPHATASE; PHOSPHORYLATION; PROTEIN KINASE C; TUMOR CELLS, CULTURED;

EID: 0030075813     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (39)

1. BRADFORD, M.: A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem 72: 248-254, 1976.
2. BRUNS, R. F.: Adenosine receptors: Roles and pharmacology. Ann. N.Y. Acad. Sci. 603: 211-226, 1990.
3. 3H] adenosine by rat cerebellar synaptosomes. Alcohol Clin. Exp. Res. 13: 371-377, 1989
4. COHEN, P.: The structure and regulation of protein phosphatases. Annu. Rev. Biochem. 58: 453-508, 1989.
5. DAR, M. S.: Central nervous system effects and behavioral interactions with ethanol of centrally administered dilazep and its metabolites in mice. Eur. J. Pharmacol. 164: 303-313, 1989.
6. DELICADO, E. G., SEN, R. P. AND MIRAS-PORTUGAL, M. T : Effects of phorbol esters and secretagogues on nitrobenzylthioinosine binding to nucleoside trans-porters and nucleoside uptake in cultured chromaffin cells. Biochem. J. 279: 651-655, 1991
7. DIAMOND, I., WRUBEL, B., ESTRIN, W. AND GORDON, A.: Basal and adenosine receptor-stimulated levels of cAMP are reduced in lymphocytes from alcoholic patients Proceedings of the National Academy of Sciences 84: 1413-1416, 1987.
8. DUNWIDDIE, T. V.: The physiological role of adenosine in the central nervous system. Int. Rev. Neurobiol. 27: 63-139, 1985.
9. FIDEU, M. D. AND MIRAS-PORTUGAL, M. T.: Steroid-induced inhibition of adenosine transport in cultured chromaffin cells. Cell. Mol. Neurobiol. 13: 493-502, 1993.
10. GORDON, A. S., COLLIER, K. AND DIAMOND, I.: Ethanol regulation of adenosine receptor-stimulated cAMP levels in a clonal neural cell line: An in vitro model of cellular tolerance to ethanol. Proceedings of the National Academy of Sciences 83: 2105-2108, 1986.
11. GORDON, A. S., KRAUSS, S. W , NAGY, L. AND DIAMOND, I.: Nucleoside transport in lymphocytes from alcoholics and non-alcoholics. In Purine and Pyrimidine Metabolism in Man. VII. Part A: Chemotherapy, ATP Depletion, and Gout, ed by R. A. Harkness, G. B. Elion and N. Zollner, pp. 387-390, Plenum Press, New York, 1991.
12. GORDON, A. S., SAPRU, M. K., KRAUSS, S. AND DIAMOND, I.: Nucleoside transport and ethanol-induced heterologous desensitization. In Alcohol, Cell Membranes and Signal Transduction in Brain, ed. by C. Ailing, I. Diamond, S. W. Leslie, G. W. Sun and W. G. Wood, pp. 195-203, Plenum Press, New York, 1993.
13. HOFFMAN, P. L. AND TABAKOFF, B.: Alterations in dopamine receptor sensitivity by chronic ethanol treatment. Nature (Lond.) 268: 551-553, 1977.
14. JAMES, S. AND RICHARDSON, P. J.: Production of adenosine from extracellular ATP at the striatal cholinergic synapse. J. Neurochem. 60: 219-227, 1993.
15. KRAUSS, S W., GHIRNIKAR, R. B., DIAMOND, I. AND GORDON, A. S.: Inhibition of adenosine uptake by ethanol is specific for one class of nucleoside transporters. Mol. Pharmacol. 44: 1021-1026, 1993.
16. LI, C., AGUAYO, L., PEOPLES, R W. AND WEIGHT, F. F.: Ethanol inhibits a neuronal ATP-gated ion channel Mol. Pharmacol. 44: 871-875, 1993.
17. LI, C., PEOPLES, R. W. AND WEIGHT, F. F.: Alcohol action on a neuronal membrane receptor: Evidence for a direct interaction with the receptor protein. Proceedings of the National Academy of Sciences 91: 8200-8204, 1994.
18. 3 receptor-mediated ion current in neuroblastoma cells and isolated adult mammalian neurons. Mol. Pharmacol. 40: 263-270, 1991.
19. MESSING, R. O., PETEESEN, C. J. AND HENRICH, C. J.: Chronic ethanol exposure increases levels of protein kinase C δ and ∈ protein kinase C-mediated phosphorylation in cultured neural cells. J. Biol. Chem. 266: 23428-23432, 1991
20. MIRAS-PORTUGAL, M. T., DELICADO, E. G , CASILLAS, T. AND SEN, R. P.: Control of nucleoside transport in neural cells: Effect of protein kinase C activation. Adv. Exp. Med. Biol. 309: 435-438, 1991.
21. s mRNA. Nature (Lond.) 333: 848-850, 1988.
22. 1-mediated inhibition. Biochem. J. 286: 681-686, 1992.
23. NAGY, L. E., DIAMOND, I., CASSO, D. J., FRANKLIN, C. AND GORDON, A. S.: Ethanol increases extracellular adenosine by inhibiting adenosine uptake via the nucleoside transporter. J. Biol. Chem 265: 1946-1951, 1990
24. NAGY, L. E., DIAMOND, I., COLLIER, K., LOPEZ, L., ULLMAN, B. AND GORDON, A.: Adenosine is required for ethanol-induced heterologous desensitization. Mol Pharmacol. 36: 744-748, 1989.
25. NAGY, L. E., DIAMOND, I. AND GORDON, A. S.: cAMP-dependent protein kinase regulates inhibition of adenosine transport by ethanol. Mol. Pharmacol. 40: 812-817, 1991.
26. PATERSON, A. R. P., CLANACHAN, A. S., CRAIK, J. D., GATI, W. P., JAKOBS, E. S., WILEY, J. S AND CASS, C. E.: Plasma membrane transport of nucleosides, nucleobases, and nucleotides: An overview. In Role of Adenosine and Adenine Nucleotides in Biological Systems, ed. by S. Imai and M. Nakazawa, pp. 133-148, Elsevier Science Publishers, London, 1991.
27. PHILLIS, J. W.: Adenosine and Adcnine Nucleotides as Regulators of Cellular Function. CRC Press, Boca Raton, 1991.
28. PROCTOR, W. R., BAKER, R. C. AND DUNWIDDIE, T. V.: Differential CNS sensitivity to PIA and theophylline in long-sleep and short-sleep mice. Alcohol 2: 287-291, 1985.
29. PROCTOR, W. R. AND DUNWIDDIE, T. V.: Behavioral sensitivity to purinergic drugs parallels ethanol sensitivity in selectively bred mice. Science (Wash. DC) 224: 519-521, 1984.
30. RABIN, R. A., EDELMAN, A. M. AND WAGNER, J A.: Activation of protein kinase A is necessary but not sufficient for ethanol-induced desensitization of cyclic AMP production. J. Pharmacol. Exp. Ther. 262: 257-262, 1992.
31. RESNICOFF, M., SELL, C., AMBROSE, D., BASERGA, R. AND RUBIN, R.: Ethanol inhibits the autophosphorylation of the insulin-like growth factor 1(IGF-1) receptor and the IGF-1-mediated proliferation of 3T3 cells J. Biol. Chem. 268: 21777-21782, 1993.
32. ROTHERMEL, J. D. AND BOTELHO, L. H P.: A mechanistic and kinetic analysis of the interaction of the diastereoisomers of adenosine 3′,5′-(cyelic)phosphoro-thioate with purified cyclic AMP-dependent protein kinase. Biochem. J. 251: 757-762, 1988.
33. SAPRU, M. K., DIAMOND, I. AND GORDON, A. S.: Adenosine receptors mediate cellular adaptation to ethanol in NG108-cells. J. Pharmacol. Exp Ther. 271: 542-548, 1993.
34. SHENOLIKAR, S. AND NAIRN, A. C.: Protein phosphatases: Recent progress. Adv. Second Messenger Phosphoprotein Res. 23: 1-121, 1991.
35. 1. Biochem. J 185: 1062-1068, 1992.
36. A receptors expressed in Xenopus oocytes. Science (Wash. DC) 249: 291-293, 1990.
37. WAFFORD, K. A., BURNETT, D. M., LEIDENHEIMER, N. J., BURT, D. R., WANG, J. B., KOFUJI, P., DUNWIDDIE, T V., HARRIS, R. A. AND SIKELA, J. M.: Ethanol sensitivity of the GABAA receptor expressed in Xenopus oocytes requires eight amino acids contained in the γ2L subunit of the receptor complex. Neuron 7: 27-33, 1991.
38. A receptors requires phosphorylation of the alternatively spliced variant of the γ2 subunit. FEBS Lett. 313: 113-117, 1992.
39. WHITE, G., LOVINGER, D. M. AND WEIGHT, F F.: Ethanol inhibits NMDA-activated current but does not alter GABA-activated current in an isolated adult mammalian neuron. Brain Res. 507: 332-336, 1990.