Comparison of the ligand binding and signaling properties of human dopamine D2 and D3 receptors in Chinese hamster ovary cells

Journal of Pharmacology and Experimental Therapeutics

Volumn 290, Issue 2, 1999, Pages 908-916

  Vanhauwe, Jurgen F M ^a   Fraeyman, Norbert ^b   Francken, Bart J B ^a   Luyten, Walter H M L ^a   Leysen, Josée E ^a  

^a JANSSEN RESEARCH FOUNDATION   (Belgium)

^b GHENT UNIVERSITY   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

3,4,4A,10B TETRAHYDRO 4 PROPYL 2H,5H [1]BENZOPYRANO[4,3 B][1,4]OXAZIN 9 OL; 7 (DIPROPYLAMINO) 5,6,7,8 TETRAHYDRO 2 NAPHTHALENOL; CYCLIC AMP; DOPAMINE; DOPAMINE 2 RECEPTOR; DOPAMINE 3 RECEPTOR; EMONAPRIDE; FORSKOLIN; GUANINE NUCLEOTIDE BINDING PROTEIN; GUANOSINE 5' O (3 THIOTRIPHOSPHATE); HALOPERIDOL; LISURIDE; NAPHTHALENE DERIVATIVE; PERTUSSIS TOXIN; RACLOPRIDE; RADIOLIGAND; RISPERIDONE; UNCLASSIFIED DRUG;

ACIDIFICATION; ANIMAL CELL; ARTICLE; CHINESE HAMSTER; COMPETITIVE INHIBITION; CONCENTRATION RESPONSE; DRUG POTENCY; DRUG RECEPTOR BINDING; HUMAN; HUMAN CELL; LIGAND BINDING; NONHUMAN; OVARY CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECEPTOR AFFINITY; SIGNAL TRANSDUCTION;

ANIMALS; BENZOPYRANS; CELL MEMBRANE; CHO CELLS; CRICETINAE; CULTURE MEDIA; CYCLIC AMP; DOPAMINE; DOPAMINE AGONISTS; EXTRACELLULAR SPACE; GTP-BINDING PROTEINS; GUANOSINE 5'-O-(3-THIOTRIPHOSPHATE); HUMANS; HYDROGEN-ION CONCENTRATION; LIGANDS; OXAZINES; RADIOLIGAND ASSAY; RECEPTORS, DOPAMINE D2; RECEPTORS, DOPAMINE D3; SIGNAL TRANSDUCTION; TETRAHYDRONAPHTHALENES;

EID: 0032766707     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (31)

1. 3 receptor agonist ligand to CHO-K1 cells. Life Sci 57:1401-1410.
2. 50) of an enzymatic reaction. Proc Natl Acad Sci USA 22:3099-3108.
3. De Keyser J (1993) Subtypes and localization of dopamine receptors in human brain. Neurochem Int 22:83-93.
4. Dohlman HG, Thorner J, Caron MG and Lefkowitz RJ (1991) Model systems for the study of seven-transmembrane-segment receptors. Annu Rev Biochem 60:653-688.
5. Dolan RJ, Fletcher P, Frith CD, Friston KJ, Frackowlak RSJ and Grasby PM (1995) Dopaminergic modulation of impaired cognitive activation in the anterior cingulate cortex in schizophrenia. Nature(Lond) 378:180-182.
6. 3 receptor. J Pharmacol Exp Ther 268:417-426.
7. 2long dopamine receptors expressed in recombinant cells. Br J Pharmacol 118:1544-1550.
8. 3 receptor. Biochem Soc Trans 24:193-198.
9. 2 dopamine receptors. Br J Pharmacol 121:731-736.
10. Heimer L (1994) Basal ganglia and related basal forebrain structures, in The Human Brain and Spinal Cord (Heimer L ed) pp 350-360, Springer-Verlag, New York.
11. Kebabian JW and Calne DB (1979) Multiple receptors for dopamine. Nature (Lond) 277:93-96.
12. 3 mRNA and binding sites in human brain. Mol Brain Res 18:187-192.
13. Leysen JE, Janssen PMF, Heylen L, Gommeren W, Van Gompel P, Lesage A, Megens AAHP and Schotte A (1998) Receptor interactions of new antipsychotics: Relation to pharmacodynamic and clinical effects. Int J Psychiatry Clin Pract 2:S3-S17.
14. 3 receptor expressed in transfected cell lines. Eur J Pharmacol 266:79-85.
15. 35S] binding. J Pharmacol Exp Ther 285:119-126.
16. 4 dopamine receptors in HEK293 cells. J Recept Signal Transduct Res 18:267-281.
17. Missale C, Nash SR, Robinson SW, Jaber M and Caron MG (1998) Dopamine receptors: From structure to function. Physiol Rev 78:189-225.
18. Neve KA and Neve RL (1997) Molecular biology of dopamine receptors, in The Dopamine Receptors (Neve KA and Neve RL eds) pp 48, Humana Press, Totowa, NJ.
19. Oestreicher EG and Pinto GF (1987) A microcomputer program for fitting enzyme inhibition equations. Comput Biol Med 17:53-68.
20. 4 receptors. J Pharmacol Exp Ther 277:186-192.
21. Owicki JC, Parce JW, Kersco KM, Sigal GB, Muis VC, Venter JC, Fraser CM and McConnell HM (1990) Continuous monitoring of receptor-mediated changes in metabolic rates of living cells. Proc Natl Acad Sci USA 87:4007-4011.
22. Palermo DP, De Graaf ME, Marotti KR, Rehberg E and Post LE (1991) Production of analytical quantities of recombinant proteins in Chinese hamster ovary cells using sodium butyrate to elevate gene expression. J Biotechnol 19:35-47.
23. Schotte A, Janssen PFM, Gommeren W, Luyten WHML, Van Gompel P, Usage A, De Loore K and Leysen JE (1996) Risperidone compared with new and reference antipsychotic drugs: In vitro and in vivo receptor binding. Psychopharmacology 124:57-73.
24. 2 receptor. Eur J Pharmacol 225:331-337.
25. 3) as a target for neuroleptics. Nature (Lond) 347:146-151.
26. 1A receptor genes. Eur J Pharmacol 227:153-162.
27. 3 receptor. Neuroreport 7:573-576.
28. 4 dopamine receptors in fibroblast and dopaminergic cell lines. J Pharmacol Exp Ther 268:495-502.
29. 3 receptors inhibit dopamine release. J Pharmacol Exp Ther 270:475-479.
30. 3 dopamine receptors. Mol Pharmacol 52:181-186.
31. Williams GV and Goldman-Rakic PS (1995) Modulation of memory fields by dopamine D1 receptors in prefrontal cortex. Nature (Lond) 17:572-575.