Transmission-blocking vaccines: Uses and current status of development

International Journal for Parasitology

Volumn 27, Issue 2, 1997, Pages 183-189

  Kaslow, David C ^a  

^a NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

Author keywords

gametes; gametocytes; malaria vaccines; mosquitoes; oocysts; ookinetes; Plasmodium falciparum; sexual stages; transmission blocking; zygotes

Indexed keywords

MALARIA VACCINE;

CONFERENCE PAPER; DNA SEQUENCE; DRUG SAFETY; HUMAN; IMMUNOGENICITY; INFECTION CONTROL; MALARIA; NONHUMAN; PLASMODIUM FALCIPARUM; VACCINATION;

ANIMALS; ANTIBODIES, PROTOZOAN; ANTIGENS, PROTOZOAN; CLINICAL TRIALS; CULICIDAE; HUMANS; MALARIA; MALARIA VACCINES; PLASMODIUM; PROTOZOAN PROTEINS; RECOMBINANT PROTEINS; VACCINES, SYNTHETIC;

DISEASE TRANSMISSION; MALARIA CONTROL; VACCINATION STRATEGY;

EID: 0031060905     PISSN: 00207519     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0020-7519(96)00148-8     Document Type: Conference Paper

References (44)

1. Barr P. J., Green K. M., Gibson H. L., Bathurst I. C., Quakyi I. A. & Kaslow D. C. 1991. Recombinant Pfs25 protein of Plasmodium falciparum elicits malaria transmission-blocking immunity in experimental animals. Journal of Experimental Medicine 174: 1203-1208.
2. Carter R. & Chen D. H. 1976. Malaria transmission blocked by immunisation with gametes of the malaria parasite. Nature 263: 57-60.
3. Carter R. & Graves P. M. 1988. Gametocytes. In Malaria: Principles and Practice of Malariology (Edited by Wernsdorfer W. H. & McGregor I.), pp. 253-305. Churchill Livingstone, Edinburgh.
4. Carter R., Coulson A., Bhatti S., Taylor B. J. & Elliott J. F. 1995. Predicted disulfide-bonded structures for three uniquely related proteins of Plasmodium falciparum, Pfs230, Pfs48/45 and Pf12. Molecular Biochemical Parasitology 71: 203-210.
5. Carter R., Graves P. M., Quakyi I. A. & Good M. F. 1989. Restricted or absent immune responses in human populations to Plasmodium falciparum gamete antigens that are targets of malaria transmission-blocking antibodies. Journal of Experimental Medicine 169: 135-147.
6. Duffy P. E., Pimenta P. & Kaslow D. C. 1993. Pgs28 belongs to a family of epidermal growth factor-like antigens that are targets of malaria transmission-blocking antibodies. Journal of Experimental Medicine 177: 505-510.
7. Feng Z., Hoffmann R. N., Nussenzweig R. S., Tsuji M., Fujioka H., Aikawa M., Lensen T. H., Ponnudurai T. & Pologe L. G. 1993. Pfs2400 can mediate antibody-dependent malaria transmission inhibition and may be the Plasmodium falciparum 11.1 gene product. Journal of Experimental Medicine 177: 273-281.
8. Grotendorst C. A., Kumar N., Carter R. & Kaushal D. C. 1984. A surface protein expressed during the transformation of zygotes of Plasmodium gallinaceum is a target of transmission-blocking antibodies. Infection and Immunity 45: 775-777.
9. Gwadz R. W. 1976. Malaria: successful immunization against sexual stage of Plasmodium gallinaceum. Science 193: 1150-1151.
10. Huber M., Cabib E. & Miller L. H. 1991. Malaria parasite chitinase and penetration of the mosquito peritrophic membrane. Proceedings of the National Academy of Sciences U.S.A. 88: 2807-2810.
11. Huff C. G., Marchbank D. F. & Shiroishi T. 1958. Changes in infectiousness of malarial gametocytes. II. Analysis of the possible causative factors. Experimental Parasitology 7: 399-417.
12. Kaslow D. C. 1993a. Toward a transmission-blocking vaccine for malaria. Vaccine Research 2: 197-205.
13. Kaslow D. C. 1993b. Transmission-blocking immunity against malaria and other vector-borne diseases. Current Opinions in Immunology 5: 557-565.
14. Kaslow D. C. 1996. Transmission-blocking vaccines. In: Malaria Vaccines, pp. 181-227. American Society of Microbiology. ASM Press, Washington, DC.
15. Kaslow D. C. & Shiloach J. 1994. Production, purification and immunogenicity of a malaria transmission-blocking vaccine candidate: TBV25-H expressed in yeast and purified using nickel-NTA agarose. Bio/Technology 12: 494-499.
16. Kaslow D. C., Bathurst I. C., Lensen T., Ponnudurai T., Barr P. J. & Keister D. B. 1994. Saccharomyces cerevisiae recombinant Pfs25 adsorbed to alum elicits antibodies that block transmission of Plasmodium falciparum. Infection and Immunity 62: 5576-5580.
17. Kaslow D. C., Isaacs S. N., Quakyi I. A., Gwadz R. W., Moss B. & Keister D. B. 1991. Induction of Plasmodium falciparum transmission-blocking antibodies by recombinant vaccinia virus. Science 252: 1310-1313.
18. Kaslow D. C., Quakyi I. A., Syin C., Raum M. G., Keister D. B., Coligan J. E., McCutchan T. F. & Miller L. H. 1988. A vaccine candidate from the sexual stage of human malaria that contains EGF-like domains. Nature 333: 74-76.
19. Kocken C. H., Jansen J., Kaan A. M., Beckers P. J., Ponnudurai T., Kaslow D. C., Konings R. N. & Schoenmakers J. G. 1993. Cloning and expression of the gene coding for the transmission-blocking target antigen Pfs48/45 of Plasmodium falciparum. Molecular and Biochemical Parasitology 61: 59-68.
20. Kumar N. & Wizel B. 1992. Further characterization of interactions between gamete surface antigens of Plasmodium falciparum. Molecular and Biochemical Parasitology 53: 113-120.
21. Laveran A. 1880. Note sur un noveau parasite trouve dans le sang du plusiers malades atteints de fievre palustre. Bulletin Academy National Medicine Paris 9: 1235.
22. Lensen A. H., Van Gemert G. J., Bolmer M. G., Meis J. F., Kaslow D., Meuwissen J. H. & Ponnudurai T. 1992. Transmission blocking antibody of the Plasmodium falciparum zygote/ookinete surface protein Pfs25 also influences sporozoite development. Parasite Immunology 14: 471-479.
23. Oaks S. C., Mitchell V. S., Pearson G. W. & Carpenter C. C. I. (Eds) 1991. Malaria: Obstacles and Opportunities: A Report of the Committee for the Study on Malaria Prevention and Control. National Academy Press, Washington, DC.
24. Paton M. G., Barker G. C., Matsuoka H., Ramesar J., Janse C. J., Waters A. P. & Sinden R. E. 1993. Structure and expression of a post-transcriptionally regulated malaria gene encoding a surface protein from the sexual stages of Plasmodium berghei. Molecular and Biochemical Parasitology 59: 263-275.
25. Quakyi I. A., Carter R., Rener J., Kumar N., Good M. F. & Miller L. H. 1987. The 230-kDa gamete surface protein of Plasmodium falciparum is also a target for transmission-blocking antibodies. Journal of Immunology 139: 4213-4217.
26. Rawlings D. J. & Kaslow D. C. 1992. A novel 40-kDa membrane-associated EF-hand calcium-binding protein in Plasmodium falciparum. Journal of Biology Chemistry 267: 3976-3982.
27. Read D., Lensen A. H. W., Bergarnie S., Haley S., Raza A. & Carter R. 1994. Transmission-blocking antibodies against multiple non-variant target epitopes of the Plasmodium falciparum gamete surface antigen Pfs230 are all complement-fixing. Parasite Immunology 16: 511-520.
28. Rener J., Carter R., Rosenberg Y. & Miller L. H. 1980. Anti-gamete monoclonal antibodies synergistically block transmission of malaria by preventing fertilization in the mosquito. Proceedings of the National Academy of Sciences U.S.A. 77: 6797-6799.
29. Rener J., Graves P. M., Carter R., Williams J. L. & Burkot T. R. 1983. Target antigens of transmission-blocking immunity on gametes of Plasmodium falciparum. Journal of Experimental Medicine 158: 976-981.
30. Riley E. M., Williamson K. C., Greenwood B. M. & Kaslow D. C. 1995. Human immune recognition of recombinant proteins representing discrete domains of the Plasmodium falciparum gamete surface protein, Pfs230. Parasite Immunology 17: 11-19.
31. Rosenberg R., Koontz L. C., Alston K. & Friedman F. K. 1984. Plasmodium gallinaceum: erythrocyte factor essential for zygote infection of Aedes egypti. Experimental Parasitology 57: 158-164.
32. Scherf A., Carter R., Petersen C., Alano P., Nelson R., Aikawa M., Mattei D., Pereira da Silva L. & Leech J. 1992. Gene activation of Pf11-1 of Plasmodium falciparum by chromosome breakage and healing: identification of gametocyte-specific protein with a potential role in gametogenesis. EMBO Journal 11: 2293-2301.
33. Shahabuddin M. & Kaslow D. C. 1994. Biology of the development of Plasmodium in the mosquito midgut: a molecular and cellular view. Bulletin Institute Pasteur 92: 119-132.
34. Shahabuddin M., Lemos F. J. A., Kaslow D. & Jacobs-Lorena M. 1996. Antibody-mediated inhibition of Aedes egypti midgut trypsins blocks sporogonic development of Plasmodium gallinaceum. Infection and Immunity 64: 739-743.
35. Shahabuddin M., Toyoshima T., Aikawa M. & Kaslow D. C. 1993. Transmission-blocking activity of a chitinase inhibitor and activation of malarial parasite chitinase by mosquito protease. Proceedings of the National Academy of Sciences U.S.A. 90: 4266-4270.
36. Sieber K. P., Huber M., Kaslow D., Banks S. M., Torii M., Aikawa M. & Miller L. H. 1991. The peritrophic membrane as a barrier: its penetration by Plasmodium gallinaceum and the effect of a monoclonal antibody to ookinetes. Experimental Parasitology 72: 145-156.
37. Stura E. A., Kang A. S., Stefanko R., Stefanko R. S., Kaslow D. C. & Satterthwait A. C. 1994. Crystallization, sequence and preliminary crystallographic data from transmission-blocking Fab 4B7 with cyclic peptides from the Pfs25 protein of Plasmodium falciparum malaria. Acta Crystallographica Section D 50: 535-542.
38. Targett G. A. T., Harte P. G., Eida S., Rogers N. C. & Ong C. S. L. 1990. Plasmodium falciparum sexual stage antigens: immunogenicity and cell-mediated responses. Immunology Letters 25: 77-82.
39. Van Amerongen A., Sauerwein R. W., Beckers P. J., Meloen R. H. & Meuwissen J. H. 1989. Identification of a! peptide sequence of the 25 kD surface protein of Plasmodium falciparum recognized by transmission-blocking monoclonal antibodies: implications for synthetic vaccine development. Parasite Immunology 11: 425-428.
40. Vermeulen A. N., Ponnudurai T., Beckers P. J. A., Verhave J., Smits M. A. & Meuwissen J. H. E. 1985. Sequential expression of antigens on sexual stage of Plasmodium falciparum accessible to transmission-blocking antibodies in the mosquito. Journal of Experimental Medicine 162: 1460-1476.
41. Williamson K. C., Criscio M. D. & Kaslow D. C. 1993. Cloning and expression of the gene for Plasmodium falciparum transmission-blocking target antigen, Pfs230. Molecular and Biochemical Parasitology 58: 355-358.
42. Williamson K. C., Fujioka H., Aikawa M. & Kaslow D. C. 1996. Stage-specific processing of Pfs230, a Plasmodium falciparum transmission-blocking vaccine candidate. Molecular and Biochemical Parasitology 78: 161-169.
43. Williamson K. C., Keister D. B., Muratova O. & Kaslow D. C. 1995. Recombinant Pfs230, a Plasmodium falciparum gametocyte protein that reduces the infectivity of Plasmodium falciparum to mosquitoes. Molecular and Biochemical Parasitology 75: 33-42.
44. Wizel B. & Kumar N. 1991. Identification of a continuous and cross-reacting epitope for Plasmodium falciparum transmission-blocking immunity. Proceedings of the National Academy of Sciences U.S.A. 88:9533-9537.