T-cell immunity to peptide epitopes of liver-stage antigen 1 in an area of Papua New Guinea in which malaria is holoendemic

Infection and Immunity

Volumn 65, Issue 12, 1997, Pages 5082-5087

  Connelly, Marc ^a   King, Christopher L ^a   Bucci, Kim ^a   Walters, Steve ^a   Genton, Blaise ^b   Alpers, Michael P ^b   Hollingdale, Michael ^c   Kazura, James W ^a  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b PAPUA NEW GUINEA INSTITUTE OF MEDICAL RESEARCH   (Papua New Guinea)

^c UNIVERSITY OF LEEDS   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CD8 ANTIGEN; CYTOKINE; EPITOPE; GAMMA INTERFERON; INTERLEUKIN 4; INTERLEUKIN 5; PARASITE ANTIGEN;

ADOLESCENT; ADULT; AGED; ARTICLE; CELLULAR IMMUNITY; CONTROLLED STUDY; ENDEMIC DISEASE; FEMALE; HUMAN; HUMAN CELL; INTERFERON PRODUCTION; LYMPHOCYTE PROLIFERATION; MAJOR CLINICAL STUDY; MALARIA FALCIPARUM; MALE; PAPUA NEW GUINEA; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; T LYMPHOCYTE SUBPOPULATION;

EID: 0030830230     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/iai.65.12.5082-5087.1997     Document Type: Article

References (46)

1. Aidoo, M., A. Lalvani, C. E. Allsopp, M. Plebanski, S. J. Meisner, P. Krausa, M. Browning, S. Morris-Jones, F. Gotch, D. A. Fidock, M. Takiguchi, K. J. H. Robson, B. M. Greenwood, P. Druilhe, H. G. Whittle, and A. V. S. Hill. 1995. Identification of conserved antigenic components for a cytotoxic T lymphocyte-inducing vaccine against malaria. Lancet 345:1003-1006.
2. Anonymous. 1997. Final report of the International Conference on Malaria in Africa. Challenges and opportunities for cooperation. International Center and National Institute of Allergy and Infectious Diseases, Bethesda, Md.
3. Bottius, E., L. BenMohammed, K. Brahimi, H. Gras, J. P. Lepers, L. Raharimalala, M. Aikawa, J. Meis, B. Slierendregt, A. Sartan, A. Thomas, and P. Druilhe. 1996. A novel Plasmodium falciparum sporozoite and liver stage antigen (SALSA) defines major B, T helper, and CTL epitopes. J. Immunol. 156:2874-2884.
4. Bottius, E., A. Guanzirolli, J.-F. Trape, C. Rogier, L. Konata, and P. Druilhe. 1996. Malaria: even more chronic in nature than previously thought; evidence for subpatent parasitaemia detectable by the polymerase chain reaction. Trans. R. Soc. Trop. Med. Hyg. 90:15-19.
5. 4a.Bucci., K., et al. Unpublished data.
6. Clyde, D. F., V. C. McCarthy, R. M. Miller, and W. E. Woodward. 1975. Immunization of man against falciparum and vivax malaria by use of attenuated sporozoites. Am. J. Trop. Med. Hyg. 24:397-401.
7. de Waal Malefyt, R., J. Haanen, H. Spits, M. Roncarolo, A. te Velde, C. Figdor, K. Johnson, R. Kastelein, H. Yssel, and J. de Vreis. 1991. Interleukin 10 (IL-10) and viral IL-10 strongly reduce antigen-specific human T cell proliferation by diminishing the antigen-presenting capacity of monocytes via downregulation of class II major histocompatihility complex expression. J. Exp. Med 174:915-924.
8. + T cell-, IFN-γ-, and nitric oxide-dependent immunity. J. Exp. Med. 183:1739-1746.
9. Ferreira, A., L. Schofield, V. Enea, H. Schellekens P. Van der Meide, W. E. Collins, R. S. Nussenzweig, and V. Nussenzueig. 1986. Inhibition of development of exoerythroeytic forms of malaria parasites hy gamma-IFN. Science 232:881-884.
10. Fidock, D. A., H. Grans-Masse, J. P. Lepers, K. Brahimi, L. BenMohamed, S. Mellouk, C. Guerin-Marchand, A. Londono, L. Raharimalala, J. Meis, G. Langsley, C. Roussilhon, A. Tartar, and P. Druihle. 1994. Plasmodium liver stage antigen-1 is well conserved and contains potent B and T cell determinants. J. Immunol. 153:190-204.
11. Genton, B., F. Al-Yaman, H.-P. Beck, J. Hii, S. Mellor, A. Narara, T. Smith, and M. P. Alpers. 1995. The epidemiology of malaria in the Wosera area. Papua New Guinea, in preparation for vaccine trials. I. Malariametric indices and immunity. Ann. Trop. Med. Parasitol. 89:359-376.
12. Genton, B., F. Al-Yaman, H. P. Beck, S. Mellor, L. Rare, M. Ginny, T. Smith, and M. P. Alpers. 1995. The epidemiology of malaria in the Wosera area. Papua New Guinea, in preparation for vaccine trials. U. Mortality and morbidity. Ann. Trop. Med. Parasitol. 89:377-390.
13. Good, M. F. 1995. Harnessing cytotoxic T lymphocytes for vaccine design. Lancet 345:999-1000.
14. Good, M. F., D. Pombo, I. A. Quakyi, E. M. Riley, R. A. Houghten, A. Menon, D. W. Ailing, J. A. Berzofsky, and L. H. Miller. 1988. Human T cell recognition of the circumsporozoite protein of Plasmodium falciparum - immunodominant T cell domains map to the polymorphic regions of the molecule. Proc. Natl. Acad. Sci. USA 85:1199-1203.
15. Guerin-Marchan, C., P. Druilhe, B. Galey, A. Londono, J. Pararaotikui, R. L. Beaudoin, C. Duheaux, A. Tartar, O. Mercerau-Puijalon, and G. Langsley. 1987. A liver stage-specific antigen of Plasmodium falciparum characterized by gene cloning. Nature 329:164-167.
16. Herrington, D., J. Davis, E. Nardin, M. Beier, J. Cortese, H. Eddy, G. Losonsky, M. Hollingdale, M. Sztein, M. Levin, R. S. Nussenzweig, D. Clyde, and R. Edelman. 1991. Successful immunization of humans with irradiated malaria sporozoites: humoral and cellular responses of the protected individuals. Am. J. Trop. Med. Hyg. 45:539-547.
17. Hill, A. V. S., J. Elvin, A. C. Willis, M. Aidoo, C. E. M. Allsopp, F. M. Gotch, X. M. Goa, M. Takiguchi, B. M. Greenwood, A. R. M. Townsend, A. J. McMichael, and H. C. Whittle. 1992. Molecular analysis of the association of HLA-B53 and resistance to severe malaria. Nature 360:434-439.
18. Hoffman, S. L., C. N. Oster, C. Mason, J. C. Bieir, J. A. Sherwood, W. R. Ballou, M. Mugambi, and J. D. Chulay. 1989. Human lymphocyte proliferative response to sporozoite T cell epitopes correlates with resistance to falciparum malaria. J. Immunol. 142:1299-1303.
19. Hoffman, S. L., M. Sedegah, and A. Malik. 1994. CTL in humans exposed to Plasmodium falciparum by immunization or natural exposure. Curr. Top. Microbiol. Immunol. 189:187-194.
20. Houghten, R. A. 1985. General method for the rapid solid-phase synthesis of large numbers of peptides: specificity of antigen-antibody interactions at the level of individual amino acids. Proc. Natl. Acad. Sci. USA 82:5131-5136.
21. Jones, T. R., and S. L. Hoffman. 1994. Malaria vaccine development. Clin. Microbiol. Rev. 7:303-310.
22. King, C., A. Medhat, I. Malhotra, M. Nafeh, A. Helmy, J. Khaudary, S. Ibrahim, M. El-Sherbiny, S. Zaky, R. Stupi, K. Brustoski, M. Shehata, and M. Shata. 1996. Cytokine control of parasite-specific anergy in human urinary schistosomiasis: IL-10 modulates lymphocyte reactivity. J. Immunol. 156:4715-4721.
23. + cells. Eur. J. Immunol. 25:587-595.
24. Krzych, U., J. A. Lyon, T. Jareed, I. Schneider, M. R. Hollingdale, D. M. Gordon, and W. R. Ballou. 1995. Lymphocytes from volunteers immunized with irradiated Plasmodium falciparum sporozoites recognize liver and blood stage malaria antigens. J. Immunol. 155:4072-4081.
25. Lalvani, A., N. Hurt, M. Aídoo, P. Kíbatala, M. Tanner, and A. V. S. Hill. 1996. Cytotoxic T lymphocytes to Plasmodium falciparum epitopes in an area of intense and perennial transmission. Eur. J. Immunol. 26:773-779.
26. Maheshwari, R. K., C. W. Czarniecki, G. P. Dulta, S.-K. Puri, B. N. Dhawan, and R. M. Friedman. 1986. Recombinant human gamma IFN inhibits simian malaria. Infect. Immun. 53:628-630.
27. Malik, A., J. E. Egan, R. A. Houghten, J. C. Sadoff, and S. L. Hoffman. 1991. Human cytotoxic T lymphocytes against the Plasmodium falciparum circumsporozoite protein. Proc. Natl. Acad. Sci. USA 88:3300-3304.
28. Margalit, H., J. L. Spouge, J. L. Cournette, K. B. Cease, C. Delisi, and J. A. Berzofsky. 1987. Prediction of immunodominant T cell antigenic sites from the primary sequence. J. Immunol. 138:2213-2229.
29. Mellouk, S., R. K. Maheshwari, A. Rhodes-Feiuillette, R. L. Beaudoin, N. Berbiguier, H. Matile, F. Miltgen, I. Landeau, S. Pied, J. P. Chigot, R. M. Friedman, and D. J. Mazier. 1987. Inhibitory effects of IFNs and IL-1 on the development of Plasmodium falciparum in human hepatocyte cultures. J. Immunol. 139:4192-4195.
30. Nardin, E. H., and R. S. Nussenzweig. 1993. T cell responses to pre-erythrocytic stages of malaria: role in protection and vaccine development against pre-erythrocytic stages. Annu. Rev. Immunol. 11:687-693.
31. Nussenzweig, R. S., and C. A. Long. 1994. Malaria vaccines: multiple targets. Science 265:1381-1383.
32. Plebanski, M., M. Aidoo, H. C. Whittle, and A. V. Hill. 1997. Precursor frequency analysis of cytotoxic T lymphocytes to pre-erythrocytic antigens of Plasmodium falciparum in West Africa. J. Immunol. 156:2849-2855.
33. Rieckmann, K. H., R. L. Beaudoin, J. S. Cassells, and K. W. Sell. 1979. Use of attenuated sporozoites in the immunization of human volunteers against falciparum malaria. Bull. W. H. O. 57(Suppl. 1):261-265.
34. Robson, K. J. H., J. R. S. Hall, M. W. Jennings, T. J. R. Harris, K. Marsh, C. I. Newbold, V. E. Tatek, and D. J. Weatherall. 1988. A highly conserved amino-acid sequence in thrombospondin, properdin, and in proteins from sporozoites and blood stages of a human malaria parasite. Nature 341:323-326.
35. Rogers, W. O., A. Malik, S. Mellouk, K. Nakamura, M. D. Rogers, A. Szarfman, D. M. Gordon, A. K. Nusslep, M. Aikawa, and S. L. Hoffman. 1992. Characterization of Plasmodium falciparum sporozoite surface protein 2. Proc. Natl. Acad. Sci. USA 89:9176-9180.
36. Romi, R., G. Sabatinelli, G. Majori, L. Ralamborunto, F. Raveloarifera, and H. Ranaivoharimina. 1994. Plasmodium falciparum circumsporozoite protein antibody prevalence in Madagascar: a longitudinal study in three different epidemiologic areas. Am. J. Trop. Med. Hyg. 51:856-862.
37. + T cells, and antibodies required for immunity to malaria sporozoites. Nature 330:664-668.
38. + T lymphocytes against Plasmodium falciparum circumsporozoitc protein. J. Immunol. 149:966-971.
39. Suhrbier, A. 1991. Immunity to the liver stage of malaria. Parasitol. Today 7:160-164.
40. Tyne, J. A., D. E. Lanar, D. M. Smith, B. T. Wellde, P. Schultheiss, L. A. Ware, E. B. Kauffman, R. A. Wirtz, C. De Taisne, G. S. N. Hui, S. P. Change, P. Church, M. R. Hollingdale, D. C. Kaslow, S. Hoffman, K. P. Guito, W. R. Ballou, J. C. Sadoff, and E. Paoletti. 1996. NYVAC-Pf7: a poxvirus-vectored, multiantigen, multistage vaccine candidate for Plasmodium falciparum malaria. Infect. Immun. 64:3833-3844.
41. + T cells in immunity to malaria sporozoites. J. Immunol. 151:2690-2698.
42. Wizel, B., R. A. Houghten, K. C. Parker, J. E. Coligan, P. Church, D. M. Gordon, W. R. Ballou, and S. L. Hoffman. 1995. Irradiated sporozoite vaccine induces HLA-B8-restricted CTL responses against two overlapping epitopes of the Plasmodium falciparum sporozoite surface protein 2. J. Exp. Med. 182:1435-1445.
43. Wizel, B. R., R. Houghten, P. Church, J. A. Tine, D. E. Lanar, D. M. Gordon, and S. L. Hoffman. 1995. HLA-A2-restricted CTL responses to multiple Plasmodium falciparum SSP2 epitopes in sporozoite-immunized volunteers. J. Immunol. 155:766-774.
44. Yang, C., Y.-P. Shi, V. Udhayakumar, M. P. Alpers, M. M. Povoa, W. A. Hawley, W. E. Collins, and A. A. Lal. 1995. Sequence variations in the non-repetitive regions of liver stage-specific antigen-1. Mol. Biochem. Parasitol. 71:291-294.
45. Zevering, Y., C. Khamboonruang, K. Rungruengthanakit, L. Tungviboonchai, J. Ruengpipattanapan, I. Pathurst, P. Barr, and M. F. Good. 1994. Life-spans of human T-cell responses to determinants from the circumsporozoite proteins of Plasmodium falciparum and Plasmodium vivax. Proc. Natl. Acad. Sci. USA 91:6118-6122.
46. Zhu, J., and M. R. Hollingdale. 1991. Structure of the Plasmodium falciparum liver stage antigen-1. Mol. Biochem. Parasitol. 48:223-226.