Intracellular Murine IFN-γ Mediates Virus Resistance, Expression of Oligoadenylate Synthetase, and Activation of STAT Transcription Factors

Journal of Immunology

Volumn 157, Issue 10, 1996, Pages 4576-4583

  Will, Antje ^a   Hemmann, Ulrike ^b   Horn, Friedemann ^b   Röllinghoff, Martin ^a   Gessner, André ^a,c  

^a UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^b RWTH AACHEN UNIVERSITY   (Germany)

^c UNIVERSITY HOSPITAL ERLANGEN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

2',5' OLIGOADENYLATE SYNTHETASE; DNA BINDING PROTEIN; GAMMA INTERFERON; STAT1 PROTEIN; STAT1 PROTEIN, MOUSE; STAT3 PROTEIN; STAT3 PROTEIN, MOUSE; TRANSACTIVATOR PROTEIN; TRANSCRIPTION FACTOR;

ANIMAL; ARTICLE; BIOSYNTHESIS; CHEMISTRY; DRUG EFFECT; ENDOPLASMIC RETICULUM; GENETIC TRANSFECTION; IMMUNOLOGY; INNATE IMMUNITY; INTRACELLULAR FLUID; L CELL; MOUSE; VESICULAR STOMATITIS VIRUS; VIROLOGY; VIRUS INFECTION;

2',5'-OLIGOADENYLATE SYNTHETASE; ANIMALS; DNA-BINDING PROTEINS; ENDOPLASMIC RETICULUM; IMMUNITY, NATURAL; INTERFERON TYPE II; INTRACELLULAR FLUID; L CELLS (CELL LINE); MICE; RHABDOVIRIDAE INFECTIONS; STAT1 TRANSCRIPTION FACTOR; STAT3 TRANSCRIPTION FACTOR; TRANS-ACTIVATORS; TRANSCRIPTION FACTORS; TRANSFECTION; VESICULAR STOMATITIS-INDIANA VIRUS;

EID: 0030588608     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (46)

1. Young, D. C., and J. D. Griffin. 1986. Autocrine secretion of GM-CSF in acute myeloblastic leukemia. Blood 68:1178.
2. Rambaldi, A., N. Wakamiya, E. Vellenga, J. Horiguchi, M. K. Warren, D. Kufe, and J. D. Griffin. 1988. Expression of the macrophage colony-stimulating factor and c-fms genes in human acute myeloblastic leukemia cells. J. Clin. Invest. 81:1030.
3. Lang, R. A., D. Metcalf, N. M. Gough, A. R. Dunn, and T. J. Gonda. 1985. Expression of a hemopoietic growth factor cDNA in a factor-dependent cell line results in autonomous growth and tumorigenicity. Cell 43:531.
4. Laker, C., C. Stocking, U. Bergholz, N. Hess, J. F. De-Lamarter, and W. Ostertag. 1987. Autocrine stimulation after transfer of the granulocyte/macrophage colony-stimulating factor gene and autonomous growth are distinct but interdependent steps in the oncogenic pathway. Proc. Natl. Acad. Sci. USA 84:8458.
5. Arima, N., Y. Daitoku, S. Ohgaki, J. Fukumori, H. Tanaka, Y. Yamamoto, K. Fujimoto, and K. Onoue. 1986. Autocrine growth of interleukin 2-producing leukemic cells in a patient with adult T cell leukemia. Blood 68:779.
6. Browder, T. M., C. E. Dunbar, and A. W. Nienhuis. 1989. Private and public autocrine loops in neoplastic cells. Cancer Cells 1:9.
7. Dunbar, C. E., T. M. Browder, J. S. Abrams, and A. W. Nienhus. 1989. COOH-terminal-modified interleukin-3 is retained intracellularly and stimulates autocrine growth. Science 245:1493.
8. Porgador, A., R. Bannerji, Y. Watanabe, M. Feldmann, E. Gilboa, and L. Eisenbach. 1993. Antimetastatic vaccination of tumor-bearing mice with two types of IFN-γ gene-inserted tumor cells. J. Immunol. 150:1458.
9. Young, H. A., and K. J. Hardy. 1995. Role of interferon-γ in immune cell regulation. J. Leukcyte Biol. 58:373.
10. De Maeyer, E., and J. De Maeyer-Guignard. 1992. Interferon-γ. Curr. Opin. Immunol. 4:321.
11. Di Marzio, P., P. Puddu, L. Conti, F. Belardelli, and S. Gessani. 1994. Interferon gamma up-regulates its own gene expression in mouse peritoneal macrophages. J. Exp. Med. 179:1731.
12. Fultz, M. J., S. A. Barber, C. W. Dieffenbach, and S. N. Vogel. 1993. Induction of IFN-gamma in macrophages by lipopolysaccharide. Int. Immunol 5:1383.
13. Böhni, R., S. Hemmi, and M. Aguet. 1994. Signaling steps involving the cytoplasmic domain of the interferon-γ receptor α-subunit are not species-specific. J. Biol. Chem. 269:14541.
14. Spitalny, G. L., and E. A. Havell. 1984. Monoclonal antibody to murine gamma interferon inhibits lymphokine-induced antiviral and macrophage tumoricidal activities. J. Exp. Med. 159:1560.
15. Bazin, H., L.-M. Xhurdebise, G. Burtonboy, A.-M. Lebacq, L. De Clerq, and F. Cormont. 1984. Rat monoclonal antibodies. I. Rapid purification from in vitro culture supernatants. J. Immunol. Methods 66:261.
16. LeClaire, R. D., M. Basu, D. M. Pinson, M. L. Redick, J. S. Hunt, P. J. Zavodny, J. L. Pace, and S. W. Russell. 1992. Characterization and use of monoclonal and polydonal antibodies against the mouse interferon-γ receptor. J. Leukocyte Biol. 51:507.
17. Gray, P., and D. V. Goeddel. 1983. Cloning and expression of murine immune interferon cDNA. Proc. Natl. Acad. Sci. USA 80:5842.
18. Studier, F. W., and B. A. Moffatt. 1986. Use of bacteriophage T7 RNA polymerase to direct selective high-level expression of cloned genes. J. Mol. Biol. 189:113.
19. Chomczynski, P., and N. Sacchi. 1987. Single-step method of RNA isolation by acidic guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162:156.
20. Krug, M. S., and S. L. Berger. 1987. First strand cDNA synthesis primed with oligo (dT). Methods Enzymol. 152:316.
21. Gessner, A., H. Blum, and M. Röllinghoff. 1993. Differential regulation of IL-9 expression after infection with Leishmania major in susceptible and resistant mice. Immunobiology 188:419.
22. Gessner, A., D. Moskophidis, and F. Lehmann-Grube. 1989. Enumeration of single interferon-γ-producing cells in mice during viral and bacterial infection. J. Immunol. 142:1293.
23. Bruns, M., and F. Lehmann-Grube. 1984. Lymphocytic choriomeningitis virus. VIII. Reciprocal formation of pseudotypes with vesicular stomatitis virus. Virology 137:49.
24. Andrew, N. C., and D. V. Faller. 1991. A rapid micropreparation technique for extraction of DNA-binding proteins from a limited number of mammalian cells. Nucleic Acids Res. 19:2499.
25. Wagner, B. J., T. E. Hayes, C. J. Hoban, and B. H. Cochran. 1990. The SIF binding element confers sis/PDGF inducibility onto the c-fos promoter. EMBO J. 9:4477.
26. Wegenka, U. M., J. Buschmann, C. Lütticken, P. C. Heinrich, and F. Horn. 1993. Acute-phase response factor, a nuclear factor binding to acute-phase response elements, is rapidly activated by interleukin-6 at the posttranslational level. Mol. Cell. Biol. 13:276.
27. Munro, S., and H. R. B. Pelham. 1987. A C-terminal signal prevents secretion of luminal ER proteins. Cell 48:899.
28. Rose-John, S., H. Schooltink, H. Schmitz-Van de Leur, J. Müllberg, P. C. Heinrich, and L. Graeve. 1993. Intracellular retention of interleukin-6 abrogates signaling. J. Biol. Chem. 268:22084.
29. Pestka, S., J. A. Langer, K. C. Zoon, and C. E. Samuel. 1987. Interferons and their actions. Annu. Rev. Biochem. 56:727.
30. Müller, M. J. Briscoe, C. Laxton, D. Guschin, A. Ziemiecki, O. Silvennoinen, A. G. Harpur, G. Barbieri, B. A. Witthuhn, C. Schindler, S. Pellegrini, A. F. Wilks, J. N. Ihle, G. R. Stark, and J. M. Kerr. 1993. The protein tyrosine kinase JAK1 complements defects in interferon-α/β and -γ signal transduction. Nature 366:129.
31. Watling, D., D. Guschin, M. Müller, O. Silvennoinen, B. A. Witthuhn, F. W. Quelle, N. C. Rogers, C. Schindler, G. R. Stark, J. N. Ihle, and I. M. Kerr. 1993. Complementation by the protein kinase JAK2 of a mutant cell line defective in the interferon-γ signal transduction pathway. Nature 366:166.
32. Shuai, K., C. Schindler, V. R. Prezioso, and J. E. Darnell, Jr. 1992. Activation of transcription by IFN-γ: tyrosine phosphorylation of a 91-kD DNA binding protein. Science 258:1808.
33. Campell, G. S., D. J. Meyer, R. Raz, D. E. Levy, J. Schwartz, and C. Carter-Su. 1995. Activation of acute phase response factor (APRF)/Stat3 transcription factor by growth hormone. J. Biol. Chem. 270:3974.
34. Watanabe, Y., K. Kuribayashi, S. Miyatake, K. Nishihara, E.-I. Nakayama, T. Taniyama, and T.-A. Sakata. 1989. Exogenous expression of mouse interferon-γ cDNA in mouse neuroblastoma C1300 cells results in reduced tumorigenicity by augmented anti-tumor immunity. Proc. Natl. Acad. Sci. USA 86:9456.
35. + T cells against wild-type tumor: correlation with antigen presentation capability. J. Exp. Med. 175:1423.
36. Strous, G. J., R. Willemsen, P. van-Kerkhof, J. W. Slot, H. J. Geuze, and H. F. Lodish. 1983. Vesicular stomatitis virus glycoprotein, albumin, and transferrin are transported to the cell surface via the same Golgi vesicles. J. Cell Biol. 97:1815.
37. Pelham, H. R. 1989. Control of protein exit from the endoplasmic reticulum. Annu. Rev. Cell Biol. 5:1.
38. Roth, M., M. Nauck, M. Tamm, A. P. Perruchoud, R. Zicsche, and L. H. Block. 1995. Intracellular interleukin-6 mediates platelet-derived growth factor-induced proliferation of nontransformed cells. Proc. Natl. Acad. Sci. USA 92:1312.
39. Gajewski, T. F., and F. W. Fitch. 1988. Anti-proliferative effect of IFN-γ in immune regulation. I. IFN-γ inhibits the proliferation of Th2 but not Th1 murine helper T lymphocyte clones. J. Immunol. 140:4245.
40. Pernis, A., S. Gupta, K. J. Gollop, E. Garfein, R. L. Coffman, C. Schindler, and P. Rothman. 1995. Lack of interferon-γ receptor β-chain and the prevention of interferon-γ signaling in Th1 cells. Science 269:245.
41. Bach, E. A., S. J.Szabo, A. S. Dighe, A. Ashkenazi, M. Aguet, K. M. Murphy, and R. D. Schreiber. 1995. Ligand-induced autoregulation of IFN-γ receptor β-chain expression in T helper cell subsets. Science 270:1215.
42. Huang, S., W. Hendriks, A. Althage, S. Hemmi, H. Bluethmann, R. Kamijo, J. Vilcek, R. Zinkernagel, and M. Aguet. 1993. Immune response in mice that lack the interferon-γ receptor. Science 259:1742.
43. Kamijo, R., D. Shapiro, J. Le, S. Huang, M. Aguet, and J. Vilcek. 1993. Generation of nitric oxide and induction of major histocompatibility complex class II antigen in macrophages from mice lacking the interferon-γ receptor. Proc. Natl. Acad. Sci. USA 90:6626.
44. Marsters, S. A., D. Pennica, E. Bach, R. D. Schreiber, and A. Ashkenazi. 1995. Interferon-γ signals via a high-affinity multisubunit receptor complex that contains two types of polypeptide chain. Proc. Natl. Acad. Sci. USA 92:5401.
45. Higashi, Y., and Y. Sokawa. 1982. Microinjection of interferon and 2′-5′-oligoadenylate into mouse L cells and their effects on virus growth. J. Biochem. 91:2021.
46. Smith, M. R., K. Muegge, J. R. Keller, H.-F. Kung, H. A. Young, and S. K. Durum. 1990. Direct evidence for an intracellular role for IFN-γ: microinjection of human IFN-γ induces Ia expression on murine macrophages. J. Immunol. 144:1777.