The role of molecules that mediate apoptosis in T-cell selection

Trends in Immunology

Volumn 22, Issue 2, 2001, Pages 107-111

  Williams, Owen ^a   Brady, Hugh J M ^b  

^a NATIONAL INSTITUTE FOR MEDICAL RESEARCH   (United Kingdom)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CELL NUCLEUS RECEPTOR; CYCLIN DEPENDENT KINASE 2; PROTEIN BCL 2; TRANSCRIPTION FACTOR;

APOPTOSIS; CELL DEATH; CELL DIFFERENTIATION; CELL SELECTION; LYMPHOCYTE PROLIFERATION; NONHUMAN; REGULATORY MECHANISM; REVIEW; T LYMPHOCYTE; THYMUS;

ANIMALS; APOPTOSIS; CLONAL DELETION; DNA-BINDING PROTEINS; T-LYMPHOCYTES; TRANSCRIPTION FACTORS;

EID: 0034921063     PISSN: 14714906     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1471-4906(00)01797-X     Document Type: Review

References (46)

1. Selection of the T cell repertoire
2. Function and specificity of T cell subsets in the mouse
3. T-cell apoptosis detected in situ during positive and negative selection in the thymus
4. Apoptotic signals delivered through the T-cell receptor of a T-cell hybrid require the immediate-early gene nur77
5. Requirement for the orphan steroid receptor Nur77 in apoptosis of T-cell hybridomas
6. A role for the orphan steroid receptor Nur77 in apoptosis accompanying antigen-induced negative selection
7. Inhibition of Nur77/Nurr1 leads to inefficient clonal deletion of self-reactive T cells
8. Apoptosis of nur77/N10-transgenic thymocytes involves the Fas/Fas ligand pathway
9. Functional redundancy of the Nur77 and Nor1 orphan steroid receptors in T-cell apoptosis
10. Unimpaired thymic and peripheral T cell death in mice lacking the nuclear receptor NGFI-B (Nur77)
11. Down-regulation of the orphan nuclear receptor ROR gamma t is essential for T lymphocyte maturation
12. Requirement for RORγ in thymocyte survival and lymphoid organ development
13. Thymocyte selection is regulated by the helix-loop-helix inhibitor protein, Id3
14. E2A deficiency leads to abnormalities in αβ T-cell development and to rapid development of T-cell lymphomas
15. B-lymphocyte development is regulated by the combined dosage of three basic helix-loop-helix genes, E2A, E2-2, and HEB
16. Thymocyte maturation is regulated by the activity of the helix-loop-helix protein, E47
17. Inhibition of T cell and promotion of natural killer cell development by the dominant negative helix loop helix factor Id3
18. Constitutive expression of the Id1 gene impairs mouse B cell development
19. Regulated expression of a gene encoding a nuclear factor, IRF-1, that specifically binds to IFN-β gene regulatory elements
20. Structurally similar but functionally distinct factors, IRF-1 and IRF-2, bind to the same regulatory elements of IFN and IFN-inducible genes
21. Targeted disruption of IRF-1 or IRF-2 results in abnormal type I IFN gene induction and aberrant lymphocyte development
22. Mice devoid of interferon regulatory factor 1 (IRF-1) show normal expression of type I interferon genes
23. + thymocytes
24. Principles of CDK regulation
25. A link between cell cycle and cell death: Bax and Bcl2 modulate Cdk2 activation during thymocyte apoptosis
26. The cyclin-dependent kinase Cdk2 regulates thymocyte apoptosis
27. Activation of Cdk2 is a requirement for antigen-mediated thymic negative selection
28. Bcl2 family: Regulators of cell death
29. + thymocytes in vitro induces early aspects of positive selection, but not apoptosis
30. Bcl2-deficient mice demonstrate fulminant lymphoid apoptosis, polycystic kidneys, and hypopigmented hair
31. Disappearance of the lymphoid system in Bcl2 homozygous mutant chimeric mice
32. Massive cell death of immature hematopoietic cells and neurons in Bcl-X-deficient mice
33. BclX regulates the survival of double-positive thymocytes
34. Bcl2 transgene inhibits T cell death and perturbs thymic self-censorship
35. Inhibition of thymocyte apoptosis and negative antigenic selection in Bcl2 transgenic mice
36. Bcl2 inhibits multiple forms of apoptosis but not negative selection in thymocytes
37. Positive and negative selection of T cells in T-cell receptor transgenic mice expressing a Bcl2 transgene
38. + thymocytes is altered by overexpression of the Bcl2 protooncogene in the thymus
39. L displays restricted distribution during T cell development and inhibits multiple forms of apoptosis but not clonal deletion in transgenic mice
40. L-regulated apoptosis in T cell development
41. The action of Bax and Bcl2 on T cell selection
42. Bcl2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death
43. T cells from baxα transgenic mice show accelerated apoptosis in response to stimuli but do not show restored DNA damage-induced cell death in the absence of p53-gene product in
44. Bcl2 and Bax function independently to regulate cell death
45. + stage during positive selection and promotes thymocyte differentiation at several control points
46. Baxα perturbs T cell development and affects cell cycle entry of T cells