Alveolar epithelial cell chemokine expression induced by specific antiviral CD8+ T-cell recognition plays a critical role in the perpetuation of experimental interstitial pneumonia

Chest

Volumn 120, Issue , 2001, Pages 11S-13S

  Zhao, Min Q ^a   Foley, Maura P ^a   Stoler, Mark H ^a   Enelow, Richard I ^a  

^a UNIVERSITY OF VIRGINIA HEALTH SYSTEM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD8 ANTIGEN; HEMAGGLUTININ; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MACROPHAGE INFLAMMATORY PROTEIN 1BETA; MONOCYTE CHEMOTACTIC PROTEIN 1; MONOCYTE CHEMOTACTIC PROTEIN 2; RNA; TUMOR NECROSIS FACTOR ALPHA;

ADOPTIVE TRANSFER; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN RECOGNITION; CELL ACTIVATION; CELL LINE; CELL MEDIATED CYTOTOXICITY; CONFERENCE PAPER; CONTROLLED STUDY; DISEASE COURSE; DISEASE SEVERITY; EFFECTOR CELL; INCUBATION TIME; INFLAMMATORY INFILTRATE; INFLUENZA; INFLUENZA VIRUS; INTERSTITIAL PNEUMONIA; LUNG ALVEOLUS EPITHELIUM; LUNG HOMOGENATE; LYMPHOCYTE CLONE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; T LYMPHOCYTE; TARGET CELL; TRANSGENIC MOUSE;

ANIMALS; CD8-POSITIVE T-LYMPHOCYTES; CHEMOKINE CCL2; CYTOTOXICITY, IMMUNOLOGIC; EPITHELIAL CELLS; LUNG DISEASES, INTERSTITIAL; MICE; MICE, TRANSGENIC; PULMONARY ALVEOLI; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0034920436     PISSN: 00123692     EISSN: None     Source Type: Journal    
DOI: 10.1378/chest.120.1_suppl.S11     Document Type: Article

References (8)

1. Usual interstitial pneumonitis is a T-cell alveolitis
2. Association of activated cytolytic lung lymphocytes with response to prednisone therapy in patients with idiopathic pulmonary fibrosis
3. Immunohistological analysis of lung tissue from patients with cryptogenic fibrosing alveolitis suggesting local expression of immune hypersensitivity
4. Distinct types of lung disease caused by functional subsets of antiviral T cells
5. Experimental T cell-mediated lung disease: Structural and functional consequences of alveolar cell recognition by CD8+ T lymphocytes
6. Perforin-independent CD8+ T cell-mediated cytotoxicity of alveolar epithelial cells is preferentially mediated by tumor necrosis factor-α: Relative insensitivity to Fas ligand
7. A lung-specific neo-antigen elicits specific CD8+ T cell tolerance with preserved CD4+ T cell reactivity
8. Alveolar epithelial cell chemokine expression triggered by antigen-specific cytolytic CD8+ T cell recognition