Tumor growth inhibition in vivo and G2/M cell cycle arrest induced by antisense oligodeoxynucleotide targeting thymidylate synthase

Journal of Pharmacology and Experimental Therapeutics

Volumn 298, Issue 2, 2001, Pages 477-484

  Berg, Randal W ^a   Werner, Melanie ^a   Ferguson, Peter J ^a   Postenka, Carl ^a   Vincent, Mark ^a,b   Koropatnick, D James ^a,b   Behrend, Elke ^a  

^a LONDON REGIONAL CANCER PROGRAM   (Canada)

^b UNIVERSITY OF WESTERN ONTARIO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ANTISENSE OLIGODEOXYNUCLEOTIDE; MESSENGER RNA; ODN 83; PROTEIN; THYMIDYLATE SYNTHASE;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CELL CYCLE G2 PHASE; CELL DEATH; CELL GROWTH; CELL PROLIFERATION; COLON CARCINOMA; CONTROLLED STUDY; DOWN REGULATION; DRUG EFFICACY; GENE TARGETING; GROWTH INHIBITION; HUMAN; HUMAN CELL; IMMUNE DEFICIENCY; ISOTOPE LABELING; MITOSIS; MITOSIS INHIBITION; PRIORITY JOURNAL; PROTEIN EXPRESSION; TUMOR GROWTH;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL CYCLE; DOWN-REGULATION; FEMALE; FLOW CYTOMETRY; HELA CELLS; HT29 CELLS; HUMANS; MICE; MICE, NUDE; NEOPLASM TRANSPLANTATION; OLIGONUCLEOTIDES, ANTISENSE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; THYMIDYLATE SYNTHASE; TRANSFECTION;

EID: 0034920194     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (37)

1. p53 controls both the G2/M and the G1 cell cycle checkpoints and mediates reversible growth arrest in human fibroblasts
2. Pharmacokinetics, biodistribution and stability of oligodeoxynucleotide phosphorothioates in mice
3. Modulation of chemosensitivity in human colon carcinoma cells by downregulating protein kinase C alpha expression
4. Identification of in vivo target RNA sequences bound by thymidylate synthase
5. Autoregulation of human thymidylate synthase messenger RNA translation by thymidylate synthase
6. Thymidylate synthase binds to c-myc RNA in human colon cancer cells and in vitro
7. Identification of a thymidylate synthase ribonucleoprotein complex in human colon cancer cells
8. Thymidylate synthase inhibitors
9. Inhibition of growth of human tumor cell lines in nude mice by an antisense of oligonucleotide inhibitor of protein kinase C-alpha expression
10. Effect of cisplatin and c-myb antisense phosphorothioate oligodeoxynucleotides combination on a human colon carcinoma cell line in vitro and in vivo
11. Antisense nucleic acids targeted to the thymidylate synthase (TS) mRNA translation start site stimulate TS gene transcription
12. WAF1, a potential mediator of p53 tumor suppression
13. Antisense down-regulation of thymidylate synthase to suppress growth and enhance cytotoxicity of 5-FUdR, 5-FU and Tomudex in HeLa cells
14. Drug resistance in colon cancer
15. Growth inhibition of human cervical cancer cells with the recombinant adenovirus p53 in vitro
16. Matrilysin-specific antisense oligonucleotide inhibits liver metastasis of human colon cancer cells in a nude mouse model
17. Flow cytometric analysis of cell-killing actions of 5-fluorouracil in human colorectal cancer cells
18. Posttranscriptional regulation of thymidylate synthase gene expression
19. Regulation of p53 expression by thymidylate synthase
20. Antisense oligonucleotides to class III beta-tubulin sensitize drug-resistant cells to Taxol
21. The thymidylate synthase inhibitor, ICI D1694, overcomes translational detainment of the enzyme
22. Modulation of drug resistance by alpha-tubulin in paclitaxel-resistant human lung cancer cell lines
23. Antitumor effect of c-myc antisense phosphorothioate oligodeoxynucleotides on human melanoma cells in vitro and in mice
24. DNA damage and p53 induction do not cause ZD1694-induced cell cycle arrest in human colon carcinoma cells
25. Chemosensitization and delayed androgen-independent recurrence of prostate cancer with the use of antisense Bcl-2 oligodeoxynucleotides
26. Apoptosis of haematopoletic cells upon thymidylate synthase inhibition is independent of p53 accumulation and CD95-CD95 ligand interaction
27. Cell cycle regulation of thymidylate synthetase gene expression in cultured mouse fibroblasts
28. The use of thymidylate synthase inhibitors in the treatment of advanced colorectal cancer: Current status
29. p53 mutations in colorectal cancer
30. Pharmacokinetics, tissue distribution and stability of antisense oligodeoxynucleotide phosphorothioate ISIS 3466 in mice
31. Effect of 2′-O-methyl antisense ORNs on expression of thymidylate synthase in human colon cancer RKO cells
32. Detection and quantitation of thymidylate synthase mRNA in human colon adenocarcinoma cell line resistant to 5-fluorouracil by competitive PCR
33. Methods for thymidyiate synthase pharmacodynamics: Serial biopsy, free and total TS, FdUMP and dUMP, and H4PteGlu and CH2-H4PteGlu assays
34. Antisense oligonucleotides as therapeutic agents - Is the bullet really magical?
35. Evidence for a second cell cycle block at G2/M by p53
36. Downstream molecular determinants of response to 5-fluorouracil and antifolate thymidylate synthase inhibitors
37. Cyclin E-cdk2 activation is associated with cell cycle arrest and inhibition of DNA replication induced by the thymidylate synthase inhibitor Tomudex