Nitric oxide synthases in vagal neurons are crucial for the regulation of heart rate in awake dogs

Basic Research in Cardiology

Volumn 96, Issue 4, 2001, Pages 395-404

  Picker, O ^a   Scheeren, T W L ^a   Arndt, J O ^a  

^a HEINRICH HEINE UNIVERSITY   (Germany)

Author keywords

Autonomic nervous system; Heart rate; Heart rate variability; Nitric oxide; Vasoconstriction

Indexed keywords

HEXAMETHONIUM; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE INHIBITOR; PLACEBO;

ANIMAL EXPERIMENT; ARTICLE; AUTONOMIC NERVOUS SYSTEM; BRADYCARDIA; CONTROLLED STUDY; DOG; DOSE TIME EFFECT RELATION; ENZYME ACTIVITY; GANGLION BLOCK; HEART RATE; HEART RATE VARIABILITY; NONHUMAN; REGULATORY MECHANISM; REST; STATISTICAL ANALYSIS; SYMPATHETIC FUNCTION; VAGUS NERVE; VASCULAR RESISTANCE; VASOCONSTRICTION; WAKEFULNESS;

ANIMALS; DOGS; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; FEMALE; GANGLIONIC BLOCKERS; HEART RATE; HEXAMETHONIUM; MALE; NEURONS; NG-NITROARGININE METHYL ESTER; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE I; VAGUS NERVE; VASCULAR RESISTANCE;

EID: 0034919125     PISSN: 03008428     EISSN: None     Source Type: Journal    
DOI: 10.1007/s003950170048     Document Type: Article

References (48)

1. Control of cardiac muscle cell function by an endogenous nitric oxide signaling system
2. Heart rate variability: Origins, methods, and interpretive caveats
3. Endothelium and blood flow mediated vasomotion in the conscious dog
4. Intrinsic heart rate in the dog determined by pharmacologic denervation
5. The role of nitric oxide in the control by the vagal nerves of the heart of the ferret
6. Evidence that the autonomic nervous system plays a major role in the L-NAME-induced hypertension in conscious rats
7. NO modulates autonomic effects in sinus discharge rate and AV nodal conduction in open-chest dogs
8. Endothelium-derived relaxing and contracting factors
9. Control of regional blood flow by endothelium-derived nitric oxide
10. Heat production and heat loss in the dog at 8-36°C environmental temperature
11. Muscarinic cholinergic regulation of cardiac myocyte ICa-L is absent in mice with targeted disruption of endothelial nitric oxide synthase
12. A cellular mechanism for nitric oxide-mediated cholinergic control of mammalian heart rate
13. An obligatory role for nitric oxide in autonomic control of mammalian heart rate
14. Is nitric oxide involved in the tonic inhibition of central sympathetic outflow in humans?
15. Inhibition of nitric oxide formation in the nucleus tractus solitarius increases renal sympathetic nerve activity in rabbits
16. Efferent vagal discharge and heart rate in response to methohexitone, althesin, ketamine and etomidate in cats
17. Interaction between neuronal nitric oxide synthase and inhibitory G protein activity in heart rate regulation in conscious mice - Rapid Communication
18. Spectral analysis of heart rate variability during isoflurane anesthesia
19. Respiratory sinus arrhythmia: Noninvasive measure of parasympathetic cardiac control
20. Cardiac vagal efferent activity and heart period in the carotid sinus reflex
21. Nitric oxide has no chronotropic effect in right atria isolated from rat heart
22. Physiology and pathophysiology of baroreceptor function and neuro-hormonal abnormalities in heart failure
23. Nitric oxide synthase in cardiac nerve fibers and neurons of rat and guinea pig heart
24. Protein expression, vascular reactivity and soluble guanylate cyclase activity in mice lacking the endothelial cell nitric oxide synthase: Contributions of NOS isoforms to blood pressure and heart rate control
25. Cardiovascular effects of NG-methyl-L-arginine in chronically instrumented conscious dogs
26. Real-time measurement of cardiac vagal tone in conscious dogs
27. Effects of NO on baroreflex control of heart rate and renal nerve activity in conscious rabbits
28. Cardiovascular response to long-term blockade of nitric oxide synthesis
29. Vagal stimulation and cardiac slowing
30. Minimal interval length for safe determination of brief heart rate variability
31. Accuracy and reproducibility of long-term implanted transit-time ultrasound flow probes in dogs
32. Impaired tissue perfusion after inhibition of endothelium-derived nitric oxide
33. NG-methyl-L-arginine, an inhibitor of L-arginine-derived nitric oxide synthesis, stimulates renal sympathetic nerve activity in vivo. A role for nitric oxide in the central regulation of sympathetic tone?
34. A large blood pressure-raising effect of nitric oxide synthase inhibition in humans
35. Reflex control of heart rate in the unanesthetized dog
36. Effect of nitric oxide synthase inhibition on the sympatho-vagal control of heart rate
37. Insights from the study of heart rate variability
38. Pharmacokinetics, plasma protein binding and urinary excretion of N-omega-nitro-L-arginine in rats
39. Nitric oxide synthase containing nerves in the atrioventricular node of the guinea pig heart
40. Direct synaptic contacts of nitric oxide synthase-immunoreactive nerve terminals on the neurons of the intracardiac ganglia of the guinea pig
41. Heart rate variability: Standards of measurement, physiological interpretation, and clinical use
42. A central nervous system action of nitric oxide in blood pressure regulation
43. Vagal modulation of heart rate during exercise: Effects of age and physical fitness
44. Eine methode zur erleichterung der blutdruckmessung bei tieren
45. Muscarinic and beta-adrenergic regulation of heart rate, force of contraction and calcium current is preserved in mice lacking endothelial nitric oxide synthase
46. Autonomic control of heart rate: Pharmacological and nonpharmacological modulation
47. Histochemical mapping of nitric oxide synthase in the rat brain
48. The influence of atropine and atenolol on the cardiac haemodynamic effects of NG-nitro-L-arginine methyl ester in conscious, Long Evans rats