Effect of nitric oxide synthase inhibition on the sympatho-vagal control of heart rate

Journal of the Autonomic Nervous System

Volumn 73, Issue 1, 1998, Pages 63-73

  Sears, Claire E ^a   Choate, Julia K ^a   Paterson, David J ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

Heart rate; Nitric oxide; Sympathetic; Vagal

Indexed keywords

CYCLIC GMP; IMIDAZOLE; ISOPRENALINE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; PROPRANOLOL;

ADRENERGIC STIMULATION; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; HEART RATE; HEART RATE VARIABILITY; NONHUMAN; PRIORITY JOURNAL; SYMPATHETIC NERVE; VAGUS NERVE; VAGUS NERVE STIMULATION;

ADRENERGIC FIBERS; ANIMALS; ARGININE; ENZYME INHIBITORS; GUINEA PIGS; HEART ATRIA; HEART RATE; INDAZOLES; ISOPROTERENOL; MALE; NEURAL INHIBITION; NITRIC OXIDE SYNTHASE; NITROARGININE; OMEGA-N-METHYLARGININE; POLYMETHACRYLIC ACIDS; PROPRANOLOL; RABBITS; SYMPATHOLYTICS; SYMPATHOMIMETICS; VAGUS NERVE;

EID: 0032572681     PISSN: 01651838     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-1838(98)00123-4     Document Type: Article

References (34)

1. Balligand J.-L., Kobzik L., Han X., Kaye D.M., Belhassen L., O'Hara D.S., Kelly R.A., Smith T.W., Michel T. Nitric oxide-dependent parasympathetic signalling is due to activation of constitutive endothelial (type III) nitric oxide synthase in cardiac myocytes. J. Biol. Chem. 270:1995;14582-14586.
2. Brahmajothi M.V., Strauss H.C., Campbell D.L. Immunolocalization of the nitric oxide synthase (NOS) isoforms in ferret heart. Am. Heart Association. A157:1998;. (Abstract).
3. Choate J.K., Paterson D.J. Inhibition of nitric oxide synthase increases the positive chronotropic response to sympathetic nerve stimulation in the isolated guinea-pig atria. Journal of Physiol. (Lond.). 506.P:1998;134. (Abstract).
4. Choate J.K., Paterson D.J. Effect of sodium nitroprusside and 8-bromo-cyclic GMP on the sympathetic control of heart rate and contractility in the isolated guinea-pig atria. J. Physiol. (Lond.). 509.P. 1998;120. (Abstract).
5. Conlon K., Collins T., Kidd C. Modulation of vagal actions on heart rate produced by inhibition of nitric oxide synthase in the anaesthetized ferret. Expt. Physiol. 81:1996;547-550.
6. Conlon K., Collins T., Kidd C. The neuronal NOS inhibitor, TRIM, attenuates vagal chronotropic and dromotropic actions on the heart of the anaesthetised ferret. J. Physiol. (Lond.). 505.P:1997;31. (Abstract).
7. Daly, M., De Burgh, M., 1997. In Peripheral and Arterial Chemoreceptors and Respiratory-cardiovascular Integration, Clarendon Press, Oxford, Monograph of the Physiological Society 46, Appendix 1, pp. 597-604.
8. Desole M.S., Kim W.-K., Rabin R.A., Laychock S.G. Nitric oxide reduces depolarization-induced calcium influx in PC12 cells by a cyclic GMP-mediated mechanism. Neuropharmacology. 33:1994;193-198.
9. Elvan A., Rubart M., Zipes D.P. NO modulates autonomic effects on sinus discharge rate and AV nodal conduction in open-chest dogs. Am. J. Physiol. 272:1997;H263-H271.
10. Garthwaite J., Boulton C.L. Nitric oxide signalling in the central nervous system. Ann. Rev. Physiol. 57:1995;683-706.
11. Greenberg S.S., Diecke F.P.J., Cantor E., Peevy K., Tanaka T.P. Inhibition of sympathetic neurotransmitter release by modulators of cyclic GMP in canine vascular smooth muscle. Eur. J. Pharmacol. 187:1990;409-423.
12. Griffith O.W., Stuehr D.J. Nitric oxide synthases: properties and catalytic mechanism. Ann. Rev. Physiol. 57:1995;707-736.
13. Halbrugge T., Lutsch K., Thyen A., Graefe K.-H. Role of nitric oxide formation in the regulation of haemodynamics and the release of noradrenaline and adrenaline. Naunyn-Schmiedeberg's Arch. Pharmacol. 344:1991;720-727.
14. Han X., Shimoni Y., Giles W.R. An obligatory role for nitric oxide in autonomic control of mammalian heart rate. J. Physiol. (Lond.). 476.2:1994;309-314.
15. Handy R.L.C., Moore P.K. Mechanism of the inhibition of neuronal nitric oxide synthase by 1-(2-trifluoromethylphenyl) imidazole (TRIM). Life Sci. 60:1997;389-394.
16. Handy R.L.C., Harb H.L., Wallace P., Gaffen Z., Whitehead K.J., Moore P.K. Inhibition of nitric oxide synthase by 1-(2-trifluoromethylphenyl) imidazole (TRIM) in vitro: antinociceptive and cardiovascular effects. Br. J. Pharmacol. 119:1996;423-431.
17. Harada S., Tokunaga S., Momohara M., Masaki H., Tagawa T., Imaizumi T., Takeshita A. Inhibition of nitric oxide formation in the nucleus tractus solitarius increases renal sympathetic nerve activity in rabbits. Circ. Res. 72:1993;511-516.
18. Kaye D.M., Wiviott S.D., Kobzik L., Kelly R.A., Smith T.W. S-nitrosothiols inhibit neuronal norepinephrine transport. Am. J. Physiol. 272:1997;H875-H883.
19. Levi R.C., Alloatti G., Fischmeister R. Cyclic GMP regulates the Ca-channel current in guinea pig ventricular myocytes. Pflügers Arch. 413:1989;685-687.
20. Liu J.-L., Murakami H., Zucker I.H. Effects of NO on baroreflex control of heart rate and renal nerve activity in conscious rabbits. Am. J. Physiol. 270:1996;R1361-R1370.
21. 2+ current is regulated by cyclic GMP-dependent protein kinase in mammalian cardiac myocytes. Proc. Natl. Acad. Sci. U.S.A. 88:1991;1197-1201.
22. Moncada S., Higgs A., Furchgott R. XIV International union of pharmacology nomenclature in nitric oxide research. Pharmacol. Rev. 49:1997;137-142.
23. Moore P.K., Handy R.L.C. Selective inhibitors of neuronal nitric oxide synthase - is no NOS really good NOS for the nervous system? T.I.P.S. 18:1997;205-211.
24. Patel K., Zhang K., Zucker I.H., Krukoff T.L. Decreased gene expression of neuronal nitric oxide synthase in hypothalamus and brainstem of rats and heart failure. Brain Res. 734:1996;109-115.
25. Schwarz P., Diem R., Dun N.J., Forstermann U. Endogenous and exogenous nitric oxide inhibits norepinephrine release from rat heart sympathetic nerves. Circ. Res. 77:1995;841-848.
26. Sears C.E., Paterson D.J. Role of nitric oxide in the rate and contraction responses to acetylcholine following adrenergic stimulation in the isolated frog heart. J. Physiol. (Lond.). 495:1996;167. (Abstract).
27. Sears C.E., Choate J.K., Paterson D.J. Effect of nifedipine on the rate response to vagal stimulation following inhibition of nitric oxide in the isolated guinea-pig atria. J. Physiol. (Lond). 501.P:1997;126.
28. Sears C.E., Choate J.K., Paterson D.J. Inhibition of nitric oxide synthase slows the heart rate recovery from cholinergic activation. J. Appl. Physiol. 84(5):1998;1596-1604.
29. Sears C.E., Choate J.K., Paterson D.J. Effect of neuronal nitric oxide synthase inhibition on the heart rate response to cardiac sympathetic and vagal nerve stimulation in the anaesthetised rabbit. J. Physiol. (Lond.). 507.P:1998;57. (Abstract).
30. Sosunov A.A., Hassall C.J.S., Loesch A., Turmaine M., Burnstock G. Nitric oxide synthase-containing neurones and nerve fibres within cardiac ganglia of rat and guinea-pig: an electron-microscopic immunocytochemical study. Cell. Tissue Res. 284:1996;19-28.
31. Travagli R.A., Gillis R.A. Nitric oxide-mediated excitatory effect on neurons of dorsal motor nucleus of vagus. Am. J. Physiol. 266:1994;G154-G160.
32. Traystman R.J., Moore L.E., Helfacr M.A., Davis S., Banasiak K., Williams M., Hurn P.D. Nitro-L-arginine analogues: dose- and time-related nitric oxide synthase inhibition in brain. Stroke. 26:1995;864-869.
33. Yoshida K., Toda N. NADPH diaphorase-positive neurons in the intracardiac plexus of human, monkey and canine right atria. Brain Res. 724:1996;256-259.
34. Zanzinger J., Seller H. Species differences in the distribution of nitric oxide synthase in brain stem regions that regulate sympathetic activity. Brain Res. 764:1997;265-268.