An oxidative stress-mediated death pathway in irradiated human leukemia cells mapped using multilaser flow cytometry

Radiation Research

Volumn 150, Issue 6, 1998, Pages 636-647

  Sheng Tanner, Xiaofang ^a   Bump, Edward A ^b   Hedley, David W ^a  

^a PRINCESS MARGARET HOSPITAL   (Canada)

^b HARVARD RADIATION ONCOLOGY PROGRAM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACUTE GRANULOCYTIC LEUKEMIA; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; FLOW CYTOMETRY; GLUTATHIONE METABOLISM; HUMAN; HUMAN CELL; MEMBRANE POTENTIAL; MITOCHONDRIAL MEMBRANE; OXIDATION REDUCTION REACTION; OXIDATIVE STRESS; PRIORITY JOURNAL;

ARA;

EID: 0031754859     PISSN: 00337587     EISSN: None     Source Type: Journal    
DOI: 10.2307/3579886     Document Type: Article

References (27)

1. Z. M. Yuan, Y. Huang, T. Ishiko, S. Kharbanda, R. Weichselbaum and D. Kufe, Regulation of DNA damage-induced apoptosis by the c-Abl tyrosine kinase. Proc. Natl. Acad. Sci. USA 94, 1437-1440 (1997).
2. S. J. Chmura, H. J. Mauceri, S. Advani, R. Heimann, M. A. Beckett, E. Nodzenski, J. Quintans, D. W. Kufe and R. R. Weichselbaum, Decreasing the apoptotic threshold of tumor cells through protein kinase C inhibition and sphingomyelinase activation increases tumor killing by ionizing radiation. Cancer Res. 57, 4340-4347 (1997).
3. J. M. Michael, M. F. Lavin and D. J. Watters, Resistance to radiation-induced apoptosis in Burkitt's lymphoma cells is associated with defective ceramide signaling. Cancer Res. 57, 3600-3605 (1997).
4. C. M. Chresta, J. R. W. Masters and J. A. Hickman, Hypersensitivity of human testicular tumors to etoposide-induced apoptosis is associated with functional p53 and a high Bax:Bcl-2 ratio. Cancer Res. 56 1834-1841 (1996).
5. R. E. Langley, S. T. Palayoor, C. N. Coleman and E. A. Bump, Modifiers of radiation-induced apoptosis. Radiat. Res. 136, 320-326 (1993).
6. S. Fan, W. S. el-Deiry, I. Bae, J. Freeman, D. Jondle, K. Bhatia, A. J. Fornace, Jr., I. Magrath, K. W. Kohn and P. M. O'Connor, p53 gene mutations are associated with decreased sensitivity of human lymphoma cells to DNA damaging agents. Cancer Res. 54, 5824-5830 (1994).
7. B. W. Zanke, K. Boudreau, E. Rubie, E. Winnett, L. A. Tibbles, L. Zon, J. Kyriakis, F-F. Liu and J. R. Woodgett, The stress-activated protein kinase pathway mediates cell death following injury induced by cis-platinum, UV irradiation or heat. Curr. Biol. 6, 606-613 (1996).
8. C. N. Kim, X. Wang, Y. Huang, A. M. Ibrado, L. Liu, G. Fang and K. Bhalla, Overexpression of bcl-xl inhibits ara-C-induced mitochondrial loss of cytochrome c and other perturbations that activate the molecular cascade of apoptosis. Cancer Res. 57, 3115-3120 (1997).
9. S. Kumar and M. F. Lavin, The ICE family of cysteine proteases as effectors of cell death. Cell Death Differ. 3, 255-267 (1996).
10. J. H. Xiang, D. T. Chao and S. J. Korsmeyer, BAX-induced cell death may not require interleukin 1β-converting enzyme-like proteases. Proc. Natl. Acad. Sci. USA 93, 14559-14563 (1996).
11. K. L. Backway, E. A. McCulloch, S. Chow and D. W. Hedley, Relationships between the mitochondrial membrane permeability transition and oxidative stress during ara-C toxicity. Cancer Res. 57, 2446-2451 (1997).
12. S. A. Susin, N. Zamzami, M. Castedo, E. Daugas, H. G. Wang, S. Geley, F. Fassy, J. C. Reed and G. Kroemer, The central executioner of apoptosis: Multiple connections between protease activation and mitochondria in Fas/APO-1/CD95- and ceramide-induced apoptosis. J. Exp. Med. 186, 25-37 (1997).
13. G. Kroemer, Mitochondrial implication in apoptosis: Towards an endosymbiont hypothesis of apoptosis evolution. Cell Death Differ. 4, 443-456 (1997).
14. A. Macho, T. Hirsch, I. Marzo, P. Marchetti, B. Dallaporta, S. A. Susin, N. Zamzami and G. Kroemer, Glutathione depletion is an early and calcium elevation is a late event of thymocyte apoptosis. J. Immunol. 158, 4612-4619 (1997).
15. G. Kroemer, The proto-oncogene Bcl-2 and its role in regulating apoptosis. Nature Med. 3, 614-620 (1997).
16. D. W. Hedley and E. A. McCulloch, Generation of reactive oxygen intermediates after treatment of blasts of acute myeloblastic leukemia with cytosine arabinoside: Role of bcl-2. Leukemia 10, 1143-1149 (1996).
17. V. Petronilli, P. Costantini, L. Scorrano, R. Colonna, S. Passamonti and P. Bernardi, The voltage sensor of the mitochondrial permeability transition pore is tuned by the oxidation-reduction state of vicinal thiols: Increase of the gating potential by oxidants and its reversal by reducing agents. J. Biol. Chem. 269, 16638-16642 (1994).
18. A. P. Halestrap, K-Y. Woodfield and C. P. Connern, Oxidative stress, thiol reagents and membrane potential modulate the mitochondrial permeability transition by affecting nucleotide binding to the adenine nucleotide translocase. J. Biol. Chem. 272, 3346-3354 (1997).
19. J. Cai and D. P. Jones, Superoxide in apoptosis: Mitochondrial generation triggered by cytochrome c release. J. Biol. Chem. 273, 11401-11404 (1998).
20. K. Polyak, Y. Xia, J. L. Zweier and B. Vogelstein, A model for p53-induced apoptosis. Nature 389, 300-304 (1997).
21. Z. B. Hu, M. D. Minden and E. A. McCulloch, Direct evidence for the participation of bcl-2 in the regulation by retinoic acid of the ara-C sensitivity of leukemic stem cells. Leukemia 9, 1667-1673 (1995).
22. J. Slingerland, M. D. Minden and S. Benchimol, Mutation of the p53 gene in human acute myelogenous leukemia. Blood 77, 1500-1507 (1991).
23. L. Fu, M. Minden and S. Benchimol, Translational regulation of human p53 gene expression. EMBO J. 15, 4392-4401 (1996).
24. D. W. Hedley and S. Chow, Evaluation of methods for measuring cellular glutathione content using flow cytometry. Cytometry 15, 349-358 (1994).
25. S. J. Martin, C. P. M. Reutelingsperger, A. J. McGahon, J. A. Rader, R. C. A. A. van Schie, D. M. LaFace and D. R. Green, Early redistribution of plasma membrane phosphatidylserine is a general feature of apoptosis regardless of the initiating stimulus: inhibition by overexpression of Bcl-2 and AbI. J. Exp. Med. 182, 1545-1556 (1995).
26. V. B. O'Donnell, D. G. Tew, O. T. G. Jones and P. J. England, Studies on the inhibitory mechanism of iodonium compounds with special reference to neutrophil NADPH oxidase. Biochem. J. 290, 41-49 (1993).
27. A. Shimamura and D. E. Fisher, p53 in life and death. Clin. Cancer Res. 2, 435-440 (1996).