Polycystin-1 transforms the cAMP growth-responsive phenotype of M-1 cells

Kidney International

Volumn 60, Issue 2, 2001, Pages 484-494

  Sutters, M ^a   Yamaguchi, T ^a   Maser, R L ^a   Magenheimer, B S ^a   St John, P L ^a   Abrahamson, D R ^a   Grantham, J J ^a   Calvet, J P ^a  

^a UNIVERSITY OF KANSAS SCHOOL OF MEDICINE   (United States)

Author keywords

Cell proliferation; Polycystic kidney disease; Signal transduction; Stable transfection

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 8 BROMO CYCLIC AMP; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE INHIBITOR; HYBRID PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; N [2 (4 BROMOCINNAMYLAMINO)ETHYL] 5 ISOQUINOLINESULFONAMIDE; POLYCYSTIN;

CARBOXY TERMINAL SEQUENCE; CELL CLONE; CELL GROWTH; CELL PROLIFERATION; CELL TRANSFORMATION; CONFERENCE PAPER; CONTROLLED STUDY; EPITHELIUM CELL; GENE OVEREXPRESSION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; KIDNEY CORTEX; KIDNEY POLYCYSTIC DISEASE; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION;

EID: 0034911986     PISSN: 00852538     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1523-1755.2001.060002484.x     Document Type: Conference Paper

References (76)

1. Autosomal dominant polycystic kidney disease
2. Extrarenal manifestations of autosomal dominant polycystic kidney disease
3. Autosomal dominant polycystic kidney disease: Clues to pathogenesis
4. Molecular basis of autosomal dominant polycystic kidney disease
5. Molecular genetics and mechanism of autosomal dominant polycystic kidney disease
6. Autosomal recessive polycystic kidney disease
7. The polycystic kidney disease 1 gene encodes a 14 kb transcript and lies within a duplicated region on chromosome 16
8. Analysis of the genomic sequence for the autosomal dominant polycystic kidney disease (PKD1) gene predicts the presence of a leucine-rich repeat: The American PKD1 Consortium (APKD1 Consortium)
9. Polycystic kidney disease: The complete structure of the PKD1 gene and its protein
10. PKD2, a gene for polycystic kidney disease that encodes an integral membrane protein
11. Polycystic kidney disease, 1: Identification and analysis of the primary defect
12. The polycystic kidney disease 1 (PKD1) gene encodes a novel protein with multiple cell recognition domains
13. The PLAT domain: A new piece in the PKD1 puzzle
14. A latrophilin/CL-1-like GPS domain in polycystin-1
15. The structure of a PKD domain from polycystin-1: Implications for polycystic kidney disease
16. Proteins with leucine-rich repeats
17. Structures and functions of multiligand lipoprotein receptors: Macrophage scavenger receptors and LDL receptor-related protein (LRP)
18. The sea urchin sperm receptor for egg jelly is a modular protein with extensive homology to the human polycystic kidney disease protein, PKD1
19. Polycystin-1, the PKD1 gene product, is in a complex containing E-cadherin and the catenins
20. The PKD1 gene product, "polycystin-1," is a tyrosine-phosphorylated protein that colocalizes with α2β1-integrin in focal clusters in adherent renal epithelia
21. Strong homophilic interactions of the Ig-like domains of polycystin-1, the protein product of an autosomal dominant polycystic kidney disease gene, PKD1
22. Polycystin-L is a calcium-regulated cation channel permeable to calcium ions
23. Specific association of the gene product of PKD2 with the TRPC1 channel
24. Co-assembly of polycystin-1 and -2 produces unique cation-permeable currents
25. 2+-permeable nonselective cation channel
26. Vascular expression of polycystin
27. Cellular localization and tissue distribution of polycystin-1
28. Characterization and expression of the PKD-1 protein, polycystin, in renal and extrarenal tissues
29. Polycystin-2 expression is developmentally regulated
30. Distinct and common developmental expression patterns of the murine pkd2 and pkd1 genes
31. Cellular and subcellular distribution of polycystin-2, the protein product of the PKD2 gene
32. Screening the 3′ region of the polycystic kidney disease 1 (PKD1) gene reveals six novel mutations
33. Seven novel mutations of the PKD2 gene in families with autosomal dominant polycystic kidney disease
34. Identification of mutations in the repeated part of the autosomal dominant polycystic kidney disease type 1 gene, PKD1, by long-range PCR
35. Novel mutations in the duplicated region of PKD1 gene
36. Location of mutations within the PKD2 gene influences clinical outcome
37. Perinatal lethality with kidney and pancreas defects in mice with a targeted Pkd1 mutation
38. Late onset of renal and hepatic cysts in Pkd1-targeted heterozygotes
39. Polycystin 1 is required for the structural integrity of blood vessels
40. Cardiac defects and renal failure in mice with targeted mutations in Pkd2
41. A human PKD1 transgene generates functional polycystin-1 in mice and is associated with a cystic phenotype
42. The molecular basis of focal cyst formation in human autosomal dominant polycystic kidney disease type I
43. Loss of the polycystic kidney disease (PKD1) region of chromosome 16p13 in renal cyst cells supports a loss-of-function model for cyst pathogenesis
44. Somatic inactivation of Pkd2 results in polycystic kidney disease
45. Mutations of PKD1 in ADPKD2 cysts suggest a pathogenic effect of trans-heterozygous mutations
46. Genetic evidence for a trans-heterozygous model for cystogenesis in autosomal dominant polycystic kidney disease
47. Polycystic kidney disease: Primary extracellular matrix abnormality or defective cellular differentiation?
48. Hyperplasia and fluid accumulation in epithelial cyst formation and growth
49. Polycystic kidney disease: Neoplasia in disguise
50. Elevated c-myc protooncogene expression in autosomal recessive polycystic kidney disease
51. Defective epidermal growth factor gene expression in mice with polycystic kidney disease
52. Elevated proto-oncogene expression in polycystic kidneys of the C57BL/6J (cpk) mouse
53. The SGP-2 gene is developmentally regulated in the mouse kidney and abnormally expressed in collecting duct cysts in polycystic kidney disease
54. C-fos expression is hypersensitive to serum-stimulation in cultured cystic kidney cells from the C57BL/6J-cpk mouse
55. Localization of overexpressed c-myc mRNA in polycystic kidneys of the cpk mouse
56. Growth factor gene expression in kidney of murine polycystic kidney disease
57. Disappearance of polycystic kidney disease in revertant c-myc transgenic mice
58. Glomerulosclerosis and renal cysts in mice transgenic for the early region of SV40
59. Renal cyst formation and multifocal neoplasia in transgenic mice carrying the simian virus 40 early region
60. The polycystic kidney disease 1 gene product mediates protein kinase C alpha-dependent and c-Jun N-terminal kinase-dependent activation of the transcription factor AP-1
61. Interaction between RGS7 and polycystin
62. The polycystic kidney disease 1 gene product modulates Wnt signaling
63. The polycystic kidney diseased-1 protein, polycystin-1, binds and activates heterotrimeric G-proteins in vitro
64. Identification of the major site of in vitro PKA phosphorylation in the polycystin-1 C-terminal cytosolic domain
65. Identification of phosphorylation sites in the PKD1-encoded protein C-terminal domain
66. PKD1 interacts with PKD2 through a probable coiled-coil domain
67. Homo- and heterodimeric interactions between the gene products of PKD1 and PKD2
68. cAMP stimulates the in vitro proliferation of renal cyst epithelial cells by activating the extracellular signal-regulated kinase pathway
69. cAMP regulates cell proliferation and cyst formation in autosomal polycystic kidney disease cells
70. Highly inducible synthesis of heterologous proteins in epithelial cells carrying a glucocorticoid-responsive vector
71. Characterization of a mouse cortical collecting duct cell line
72. Cortisol induces rapid accumulation of whey acid protein mRNA but not of asl and b-casein mRNA in rabbit mammary explants
73. Mouse plasma glutathione peroxidase: cDNA sequence analysis and renal proximal tubular expression and secretion
74. Anion secretion drives fluid secretion by monolayers of cultured human polycystic cells
75. In vitro fluid secretion by epithelium from polycystic kidneys
76. Growth characteristics of cells cultured from two murine models of polycystic kidney disease