K-ras mutations and HLA-DR expression in large bowel adenomas

British Journal of Cancer

Volumn 74, Issue 1, 1996, Pages 99-108

  Norheim Andersen, S ^a,b   Breivik, J ^b   Lovig T ^a   Meling, G I ^c   Gaudernack, G ^b   Clausen, O P F ^a   Schjolberg A ^a   Fausa, O ^a   Langmark, F ^d   Lund, E ^e   Rognum, T O ^a  

^a UNIVERSITY OF OSLO   (Norway)

^b OSLO UNIVERSITY HOSPITAL   (Norway)

^c DIAKONHJEMMET HOSPITAL   (Norway)

^d CANCER REGISTRY OF NORWAY   (Norway)

^e UNIVERSITY OF TROMSØ   (Norway)

Author keywords

Dysplasia; HLA DR; Immunohistochemistry; K ras; Large bowel adenoma; Polymerase chain reaction restriction fragment length polymorphism

Indexed keywords

HLA DR ANTIGEN;

ADENOMA; ADULT; AGED; ANTIGEN EXPRESSION; ARTICLE; COLORECTAL CANCER; CONTROLLED STUDY; DYSPLASIA; FEMALE; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; MUTATION RATE; ONCOGENE K RAS; POINT MUTATION; PRIORITY JOURNAL; SEX DIFFERENCE; STATISTICAL ANALYSIS;

EID: 8944243540     PISSN: 00070920     EISSN: None     Source Type: Journal    
DOI: 10.1038/bjc.1996.322     Document Type: Article

References (51)

1. ANDO M, MARUYAMA M, OTO M, TAKEMURA K, ENDO M AND YUASA Y. (1991). Higher frequency of point mutations in the c-K-ras 2 gene in human colorectal adenomas with severe atypia than in carcinomas. Jpn. J. Cancer Res., 82, 245-249.
2. ANDO M, TAKEMURA K, MARUYAMA M, ENDO M, IWAMA T AND YUASA Y. (1992). Mutations in c-K-ras 2 gene codon 12 during colorectal tumorigenesis in familial adenomatous polyposis. Gastroenterology, 103, 1725-1731.
3. BEDOSSA P, POYNARD T, BACCI J, NAVEAU S, LEMAIGRE G, CHAPUT JC AND MARTIN E. (1990). Expression of histocompatibility antigens and characterization of the lymphocyte infiltrate in hyperplastic polyps of the large bowel. Hum. Pathol., 21, 319-324.
4. BODMER W, BISHOP T AND CARRAN P. (1994). Genetic steps in colorectal cancer. Nature Genet., 6, 217-219.
5. BOS JL, FEARON ER, HAMILTON SR, VERLAAN-DE VRIES M, VAN BOOM JH, VAN DER EB AJ AND VOGELSTEIN B. (1987). Prevalence of ras gene mutations in human colorectal cancers. Nature, 327, 293-297.
6. BRANDTZAEG P. (1974). Mucosal and glandular distribution of immunoglobulin components. Immunohistochemistry with a cold ethanol-fixation technique. Immunology, 26, 1101-1114.
7. BRANDTZAEG P AND ROGNUM TO. (1983). Evaluation of tissue preparation methods and paired immunofluorescence staining for immunocytochemistry of lymphomas. Histochem. J., 15, 655-689.
8. BREIVIK J, MELING GI, SPURKLAND A, ROGNUM TO AND GAUDERNACK G. (1994). K-ras mutation in colorectal cancer: relations to patient age, sex and tumour location. Br. J. Cancer, 69, 367-371.
9. BURMER GC AND LOEB LA. (1989). Mutations in the KRAS2 oncogene during progressive stages of human colon carcinoma. Proc. Natl Acad. Sci. USA, 86, 2403-2407.
10. DAAR AS, FUGGLE SV, TING A AND FABRE JW. (1982). Anomalous expression of HLA-DR antigens on human colorectal cancer cells. J. Immunol., 129, 447-449.
11. DAAR AS, FUGGLE SV, FABRE JW, TING A AND MORRIS PJ. (1984). The detailed distribution of MHC class II antigens in normal human organs. Transplantation, 38, 293-298.
12. DEGENER T, MOMBURG F AND MÖLLER P. (1988). Differential expression of HLA-DR, HLA-DP, HLA-DQ and associated invariant chain (Ii) in normal colorectal mucosa, adenoma and carcinoma. Virchows Arch. A, 412, 315-322.
13. FARR CJ, MARSHALL CJ, EASTY DJ, WRIGHT NA, POWELL SC AND PARASKEVA C. (1988). A study of ras gene mutations in colonic adenomas from familial polyposis coli patients. Oncogene, 3, 673-678.
14. FORRESTER F, ALMOGUERA C, HAN K, GRIZZLE E AND PERUCHO M. (1987). Detection of high incidence of K-ras oncogenes during human colon tumorigenesis. Nature, 327, 298-303.
15. + T cells recognize a peptide corresponding to a common mutation (13Gly→Asp). Int. J. Cancer. 56, 40-45.
16. GEDDE-DAHL T, III, ERIKSEN JA, THORSBY E AND GAUDERNACK G. (1992a). T-cell responses against products of oncogenes: Generation and characterization of human T-cell clones specific for p21 ras-derived synthetic peptides. Hum. Immunol., 33, 266-274.
17. GEDDE-DAHL T, III, SPURKLAND A, ERIKSEN JA, THORSBY E AND GAUDERNACK G. (1992b). Memory T cells of a patient with follicular thyroid carcinoma recognise peptides derived from mutated p21 ras (GIn→Leu61). Int. Immunol., 4, 1331-1337.
18. GEDDE-DAHL T, III, FOSSUM B, ERIKSEN JA, THORSBY E AND GAUDERNACK G. (1993). T cell clones specific for p21 ras-derived peptides: characterization of their fine specificity and HLA restriction. Eur. J. Immunol., 23, 754-760.
19. GEDDE-DAHL T, III, NILSEN E, THORSBY E AND GAUDERNACK G. (1994). Growth inhibition of a colonie adenocarcinoma cell line (HT29) by T cells specific for mutant p21 ras. Cancer Immunol. Immunother., 38, 127-134.
20. GHOSH AK, MOORE M, STREET AJ, HOWAT JMT AND SCHOFIELD PF. (1986). Expression of HLA-D sub-region products on human colorectal carcinoma. Int. J. Cancer, 38, 459-464.
21. GUTIERREZ J, LOPEZ NEVOT MA, CABRERA T, OLIVA R, ESQUIVIAS J, RUIZ-CABELLO F AND GARRIDO F. (1987). Class I and II HLA antigen distribution in normal mucosa, adenoma and colon carcinoma: Relation with malignancy and invasiveness. Exp. Clin. Immunogenet., 4, 144-152.
22. GUTIERREZ J, RUIZ-CABELLO F, LÓPEZ NEVOT MA, CABRERA T, ESQUIVIAS J AND GARRIDO F. (1990). Class II HLA antigen expression in Familial polyposis coli is related to the degree of dysplasia. Immunobiol., 180, 138-148.
23. HORIE Y, CHIBA M, IIZUKA M, IGARASHI K AND MASAMUNE O. (1990). HLA antigens on colorectal adenoma and cancer cells. Tohoku J. Exp. Med., 160, 311-322.
24. JASS JR AND SOBIN LH. (1989). Histological Typing of Intestinal Tumours, 2nd edn. World Health Organization International Histological Classification of Tumours. Springer-Verlag: Berlin.
25. JEN J, POWELL SM, PAPADOPOULOS N, SMITH KJ, HAMILTON SR, VOGELSTEIN B AND KINZLER KW. (1994). Molecular determinants of dysplasia in colorectal lesions. Cancer Res., 54, 5523-5526.
26. JUNG S AND SCHLUESENER HJ. (1991). Human T lymphocytes recognize a peptide of single point-mutated, oncogenic ras proteins. J. Exp. Med., 173, 273-276.
27. KAHN SM, JIANG W, CULBERTSON TA, WEINSTEIN IB, WILLIAMS GM, TOMITA N AND RONAI Z. (1991). Rapid and sensitive nonradio-active detection of mutant K-ras genes via 'enriched' PCR amplification. Oncogene, 6, 1079-1083.
28. KIM H, JEN J, VOGELSTEIN B AND HAMILTON SR. (1994). Clinical and pathological characteristics of sporadic colorectal carcinomas with DNA replication errors in microsatellite sequences. Am. J. Pathol., 145, 148-156.
29. LANDIS JR AND KOCH GG. (1977). The measurement of observer agreement for categorical data. Biometrics, 33, 159-174.
30. MCDOUGALL CJ, NGOI SS, GOLDMAN IS, GODWIN T, FELIX J, DECOSSE JJ AND RIGAS B. (1990). Reduced expression of HLA class I and II antigens in colon cancer. Cancer Res., 50, 8023-8027.
31. MCLELLAN EA, OWEN RA, STEPNIEWSKA KA, SHEFFIELD JP AND LEMOINE NR. (1993). High frequency of K-ras mutations in sporadic colorectal adenomas. Gut, 34, 392-396.
32. MAYER L AND SHLIEN R. (1987). Evidence for function of Ia molecules on gut epithelial cells in man. J. Exp. Med., 166, 1471-1483.
33. MIYAKI M, SEKI M, OKAMOTO M, YAMANAKA A, MAEDA Y, TANAKA K, KIKUCHI R, IWAMA T, IKEUCHI T, TONOMURA A, NAKAMURA Y, WHITE R, MIKI Y, UTSUNOMIYA J AND KOIKE M. (1990). Genetic changes and histopathological types in colorectal tumors from patients with familial polyposis coli. Cancer Res., 50, 7166-7173.
34. MÖLLER P, KORETZ K, SCHLAG P AND MOMBURG F. (1991) Frequency of abnormal expression of HLA-A, B, C and HLA-DR molecules, invariant chain, and LFA-3 (CD58) in colorectal carcinoma and its impact on tumor recurrence. Int. J. Cancer, Suppl. 6, 155-162.
35. MOMBURG F, DEGENER T, BACCHUS E, MOLDENHAUER G, HÄMMERLING G AND MÖLLER P. (1986). Loss of HLA-A, B, C and de novo expression of HLA-D in colorectal cancer. Int. J. Cancer, 37, 179-184.
36. MUTO T, BUSSEY HJR AND MORSON B. (1975). The evolution of cancer of the colon and rectum. Cancer, 36, 2251-2270.
37. NORAZMI M, HOHMANN AW, SKINNER JM AND BRADLEY J. (1989). Expression of MHC class I and class II antigens in colonic carcinomas. Pathology, 21, 248-253.
38. NORHEIM ANDERSEN S, ROGNUM TO, LUND E, MELING GI AND HAUGE S. (1993). Strong HLA-DR expression in large bowel carcinomas is associated with good prognosis. Br. J. Cancer, 68, 80-85.
39. NOWELL PC. (1976). The clonal evolution of tumor cell populations. Science, 194, 23-28.
40. PRETLOW TP, BRASITUS TA, FULTON NC, CHEYER C AND KAPLAN EL. (1993). K-ras mutations in putative preneoplastic lesions in human colon. J. Natl Cancer Inst., 85, 2004-2007.
41. ROGNUM TO, FAUSA O AND BRANDTZAEG P. (1982). Immunohistochemical evaluation of carcinoembryonic antigen, secretory component, and epithelial IgA in tubular and villous large bowel adenomas with different grades of dysplasia. Scand. J. Gastroenterol., 17, 341-348.
42. ROGNUM TO, BRANDTZAEG P AND THORUD E. (1983). Is heterogenous expression of HLA-DR antigens and CEA along with DNA-profile variations evidence of phenotypic instability and clonal proliferation in human large bowel carcinomas? Br. J. Cancer, 48, 543-551.
43. ROGNUM TO, BRANDTZAEG P, ELGJO K AND FAUSA O. (1987). Heterogenous epithelial expression of class II (HLA-DR) determinants and secretory component related to dysplasia in ulcerative colitis. Br. J. Cancer, 56, 419-424.
44. RUIZ-CABELLO F, LÓPEZ NEVOT MA AND GARRIDO F. (1988). MHC class I and II gene expression on human tumors. Adv. Exp. Med. Biol., 233, 119-128.
45. SANGER F, NICLEN S AND COULSEN AR. (1977). DNA sequencing with chain terminating inhibitors. Proc. Natl Acad. Sci. USA, 74, 5463-5467.
46. SASAKI M, SUGIO K AND SASAZUKI T. (1990). K-ras activation in colorectal tumors from patients with familial polyposis coli. Cancer, 65, 2576-2579.
47. SCOTT N, BELL SM, SAGAR P, BLAIR GE, DIXON ME AND QUIRKE P. (1993). p53 expression and K-ras mutation in colorectal adenomas. Gut, 34, 621-624.
48. SOH K, YANAGISAWA A, HIRATSUKA H, SUGANO H AND KATO Y. (1993). Variation in K-ras codon 12 point mutation rate with histological atypia within individual colorectal tumours. Jpn. J. Cancer Res., 84, 388-393.
49. TSIOULIAS G, GODWIN TA, GOLDSTEIN MF, MCDOUGALL CJ, SING-SHANG N, DECOSSE JJ AND RIGAS B. (1992). Loss of colonic HLA antigens in Familial adenomatous polyposis. Cancer Res., 52, 3449-3452.
50. VOGELSTEIN B, FEARON ER, HAMILTON SR, KERN SE, PREISINGER AC, LEPPERT M, NAKAMURA Y, WHITE R, SMITS AMM AND BOS JL. (1988). Genetic alterations during colorectal-tumor development. N. Engl. J. Med., 319, 525-532.
51. YAMASHITA N, MINAMOTO T, OCHIAI A, ONDA M AND ESUMI H. (1995). Frequent and characteristic K-ras activation and absence of p53 protein accumulation in aberrant crypt foci of the colon. Gastroenterology, 108, 434-440.