Effect of K-ras mutation on morphogenesis of correlated adenomas and early cancers: Relationship to distribution of proliferating cells

Human Pathology

Volumn 27, Issue 10, 1996, Pages 1042-1049

  Kobayashi, Masaaki ^a   Watanabe, Hidenobu ^a   Ajioka, Yoichi ^a   Honma, Terasu ^a   Asakura, Hitoshi ^a  

^a NIIGATA UNIVERSITY   (Japan)

Author keywords

cancer; cell proliferation; colorectal adenoma; immunostaining; macroscopic type

Indexed keywords

MONOCLONAL ANTIBODY KI 67;

ARTICLE; CELL PROLIFERATION; COLON ADENOMA; COLON CARCINOGENESIS; COLORECTAL CANCER; DIGESTIVE SYSTEM CANCER; GENE MUTATION; HISTOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; ONCOGENE K RAS;

EID: 0029859569     PISSN: 00468177     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0046-8177(96)90281-6     Document Type: Article

References (26)

1. Vogelstein B, Fearon ER, Hamilton SR, et al: Genetic alterations during colorectal-tumor development. N EnglJ Med 319:525-532, 1988
2. Soh K, Yanagisawa A, Hiratsuka H, et al: Variation in K-ras codon 12 point mutation rate with histological atypia within individual colorectal tumors. Jpn J Cancer Res 84:388-393, 1993
3. Aoki T, Takeda S, Yanagisawa A, et al: APC and p53 mutations in de novo colorectal adenocarcinomas. Hum Mutat 3:342-346, 1994
4. Yamagata S, Muto T, Uchida Y, et al: Lower incidence of K-ras codon 12 mutation in flat colorectal adenomas than in polypoid adenomas. Jpn J Cancer Res 85:147-151, 1994
5. Fujimori T, Satonaka K, Yamamura-Idei Y, et al: Non-involvement of ras mutation in flat colorectal adenomas and carcinomas. Int J Cancer 57:51-55, 1994
6. Minamoto T, Sawaguchi K, Mai M, et al: Infrequent K-ras activation in superficial-type (flat) colorectal adenomas and adenocarcinomas. Cancer Res 54:2841-2844, 1994
7. Yamagata S, Muto T, Uchida Y, et al: Polypoid growth and K-ras codon 12 mutation in colorectal cancer. Cancer 75:953-957, 1995
8. Honma T: Study of epithelial cell proliferation in colorectal mucosa by monoclonal antibody against DNA polymerase a. Niigata Med J 106:89-97, 1992 (in Japanese with English abstr)
9. Kobayashi M, Watanabe H, Ajioka Y, et al: PCNA-positive cell distribution in depressed types of early carcinoma and adenoma of the large intestine. Gastroenterol Jpn 27:684, 1992
10. Kobayashi M, Watanabe H, Ajioka Y, et al: Proliferating cell nuclear antigen/cyclin expression in small adenomas of large intestine in relation to size and macroscopic appearance. J Gastroenterol 29:139-146, 1994
11. Maeo S, Ajioka Y, Watanabe H, et al: The proliferating cell nuclear antigen (PCNA) index correlates with the grade of cytologic atypia in well-differentiated early adenocarcinomas of the large intestine. Pathology International 45:359-365, 1995
12. Watanabe H, Ajioka Y, Yamaguchi M, et al: Relationship of colorectal adenoma and colorectal carcinoma: Based on the author's diagnosis criteria. Stomach Intest 24:253-259, 1989 (in Japanese)
13. Jass JR, Sobin LH: World Health Organization Histological typing of intestinal tumors (ed 2). Berlin, Springer-Verlag, 1989
14. OohashiY, Watanabe H, Ajioka Y, et al: p53 Immunostaining distinguishes malignant from benign lesions of the gall-bladder. Pathol Int 45:58-65, 1995
15. Ohshima S, Shimizu Y, Takahama M: Detection of c-K-ras gene mutation in paraffin sections of adenocarcinoma and atypical bronchioloalveolar cell hyperplasia of human lung. Virchows Arch 424:129-134, 1994
16. McCoy M, Bargmann CI, Weinberg RA: Human colon carcinoma Ki-ras2 oncogene and its corresponding proto-oncogene. Mol Cell Biol 4:1577-1582, 1984
17. Berrozpe G, Schaeffer J, Peinado MA, et al: Comparative analysis of mutations in the p53 and K-ras genes in pancreatic cancer. Int J Cancer 58:185-191, 1994
18. Muto T, Kamiya J, Sawada T, et al: Small "flat adenoma" of the large bowel with special reference to its clinicopathologic features. Dis Colon Rectum 28:847-851, 1985
19. Wolber RA, Owen DA: Flat adenomas of the colon. HUM PATHOL 22:70-74, 1991
20. Kubota O, Kino I: Minute adenomas of the depressed type in familial adenomatous polyposis of the colon. Cancer 72:1159-1164, 1993
21. Minamoto T, Swaguchi K, Ohta T, et al: Superficial-type adenomas and adenocarcinomas of the colon and rectum: A comparative morphological study. Gastroenterology 106:1436-1443, 1994
22. Tada S, Yao T, Iida M, et al: Clinicopathologic study of small flat colorectal carcinoma. Cancer 74:2430-2435, 1994
23. Yao T, Tada S, Tsuneyoshi M: Colorectal counterpart of gastric depressed adenoma: A comparison with flat and polypoid adenomas with special reference to the development of pericryptal fibroblasts. Am J Surg Pathol 18:559-568, 1994
24. Yao T, Tsuneyoshi M, Matsumoto T, et al: Depressed adenoma of the colorectum: Analysis of proliferative activity using immunohistochemical staining for proliferating cell nuclear antigen (PCNA). Pathol Int 44:520-527, 1994
25. Barbacid M: ras genes. Ann Rev Biochem 56:779-827, 1987
26. Miyaki M, Seki M, Okamoto M, et al: Genetic changes and histopathological types in colorectal tumors from patients with familial adenomatous polyposis. Cancer Res 50:7166-7173, 1990