The WASp-like protein scar regulates macropinocytosis, phagocytosis and endosomal membrane flow in Dictyostelium

Journal of Cell Science

Volumn 114, Issue 14, 2001, Pages 2673-2683

  Seastone, D J ^a   Harris, E ^a   Temesvari, L A ^a   Bear, J E ^a   Saxe, C L ^a   Cardelli, J ^a  

^a LOUISIANA STATE UNIVERSITY HEALTH SCIENCES CENTER   (United States)

Author keywords

Actin; Macropinocytosis; Phagocytosis; Scar

Indexed keywords

CELL PROTEIN; CYTOCHALASIN A; F ACTIN; MONOMER; PROFILIN; PROTEIN SCAR; UNCLASSIFIED DRUG; WASP PROTEIN;

ACTIN POLYMERIZATION; ANIMAL CELL; ARTICLE; CELL LINE; CELL MEMBRANE; CELL TRANSPORT; CONTROLLED STUDY; CYTOSKELETON; DEVELOPMENTAL DISORDER; DICTYOSTELIUM DISCOIDEUM; ENDOCYTOSIS; ENDOSOME; EXOCYTOSIS; FLUORESCENCE MICROSCOPY; GENE DISRUPTION; GENETIC ANALYSIS; GENETIC CODE; GENETICS; LYSOSOME; MODEL; MOVEMENT (PHYSIOLOGY); MUTATION; NONHUMAN; PARTICULATE MATTER; PHAGOCYTOSIS; PHENOTYPE; PINOCYTOSIS; PREDICTION; PRIORITY JOURNAL; PROTEIN FAMILY; PROTEIN INTERACTION; REGULATORY MECHANISM; SCREENING;

ACTINS; ANIMALS; CONTRACTILE PROTEINS; DICTYOSTELIUM; ENDOSOMES; EXOCYTOSIS; LYSOSOMES; MICROFILAMENT PROTEINS; MUTAGENESIS; PHAGOCYTOSIS; PINOCYTOSIS; PROFILINS; PROTEIN TRANSPORT; PROTEINS; PROTOZOAN PROTEINS; WISKOTT-ALDRICH SYNDROME PROTEIN;

EID: 0034909964     PISSN: 00219533     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (52)

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2. Two GTPases, Cdc42 and Rac, bind directly to a protein implicated in the immunodeficiency disorder Wiskott-Aldrich syndrome
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5. Inactivation of two Dictyostelium discoideum genes, DdPIK1 and DdPIK2, encoding proteins related to mammalian phosphatidylinositide 3-kinases, results in defects in endocytosis, lysosome to postlysosome transport and cytoskeleton organization
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13. Disease mechanism: Unravelling Wiskott-Aldrich syndrome
14. Direct interaction of the Wiskott-Aldrich syndrome protein with the GTPase Cdc42
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19. Scar, a WASp-related protein, activates nucleation of actin filaments by the Arp2/3 complex
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21. Involvement of the Arp2/3 complex in phagocytosis mediated by FcgammaR or CR3
22. 2-dependent manner downstream of tyrosine kinases
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34. The interaction between N-WASP and the Arp2/3 complex links Cdc42-dependent signals to actin assembly
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50. Interactions of Acanthamoeba profilin with actin and nucleotides bound to actin
51. Spatial control of actin polymerization during neutrophil chemotaxis
52. Actin polymerization is induced by Arp2/3 protein complex at the surface of Listeria monocytogenes