Monoclonal antibody BB9 raised against bone marrow stromal cells identifies a cell-surface glycoprotein expressed by primitive human hemopoietic progenitors

Experimental Hematology

Volumn 29, Issue 8, 2001, Pages 981-992

  Ramshaw, Hayley S ^a   Haylock, David ^b   Swart, Bernadette ^a   Gronthos, Stan ^a   Horsfall, Martyn J ^a   Niutta, Silvana ^a   Simmons, Paul J ^b  

^a INSTITUTE OF MEDICAL AND VETERINARY SCIENCE   (Australia)

^b PETER MACCALLUM CANCER CENTRE   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

MEMBRANE ANTIGEN; MONCLONAL ANTIBODY BB9; MONOCLONAL ANTIBODY; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIBODY PRODUCTION; ANTIGEN BINDING; ANTIGEN EXPRESSION; ARTICLE; CELL DIFFERENTIATION; CELL ISOLATION; CELL LINE; CELLULAR IMMUNITY; COCULTURE; CONTROLLED STUDY; HEMATOPOIESIS; HUMAN; HUMAN CELL; HYBRIDOMA; IMMUNIZATION; IMMUNOCYTOCHEMISTRY; IMMUNOPRECIPITATION; IN VITRO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; STEM CELL; STROMA CELL; TECHNIQUE;

ANIMALS; ANTIBODIES, MONOCLONAL; ANTIBODY SPECIFICITY; ANTIGENS, CD; ANTIGENS, CD34; BONE MARROW CELLS; BREAST NEOPLASMS; CELL LINE; CELL SEPARATION; CRYOPRESERVATION; FEMALE; FLOW CYTOMETRY; HEMATOPOIETIC STEM CELL MOBILIZATION; HEMATOPOIETIC STEM CELLS; HL-60 CELLS; HUMANS; HYBRIDOMAS; JURKAT CELLS; K562 CELLS; LEUKOCYTES; MEMBRANE GLYCOPROTEINS; MICE; MICE, INBRED BALB C; MULTIPLE MYELOMA; STROMAL CELLS; TUMOR CELLS, CULTURED;

EID: 0034904881     PISSN: 0301472X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0301-472X(01)00671-3     Document Type: Article

References (48)

1. + marrow cells in patients with breast cancer or neuroblastoma
2. Report on the CD34 cluster workshop
3. CD34; Structure, biology and clinical utility
4. Characterization and partial purification of human marrow cells capable of initiating long-term hematopoiesis in vitro
5. Characterization of a human hematopoietic progenitor cell capable of forming blast cell containing colonies in vitro
6. - hematopoietic stem cells
7. Isolation of a candidate human hematopoietic stem-cell population
8. Expression of Thy-1 on human hematopoietic progenitor cells
9. AC133, a novel marker for human hematopoietic stem and progenitor cells
10. Expression of novel surface antigens on early hematopoietic cells
11. + cells isolated from cord blood are highly enriched in long-term culture-initiating cells, NOD/SCID-repopulating cells and dendritic cell progenitors
12. CD34 expression by stromal precursors in normal human adult bone marrow
13. The 'common stem cell' hypothesis reevaluated; Human fetal bone marrow contains separate populations of hematopoietic and stromal progenitors
14. The biology and application of human bone marrow stromal cell precursors
15. Identification and functional cloning of MGC-24, a mucin-like molecule expressed by haemopoietic progenitors and bone marrow stromal cells; A negative regulator of haemopoiesis
16. Mouse bone marrow stromal cell line MC3T3-G2/PA6 with hematopoietic-supporting activity expresses high levels of stem cell antigen Sca-1
17. Single high doses of cyclophosphamide enable the collection of high numbers of hemopoietic stem cells from the peripheral blood
18. Increased levels of megakaryocyte progenitors in peripheral blood mobilized by chemotherapy and/or haemopoietic growth factor protocols
19. + fraction of adult human bone marrow contains the osteogenic precursors
20. The E7 gene of human papillomavirus type-16 is sufficient for immortalization of human epithelial cells
21. Immortalization of human keratinocytes with human papilloma virus DNA
22. Human bone marrow stromal cell precursors; identification and development potential
23. Continuous cultures of fused secreting antibody of predefined specificity
24. Antibody production by hybridomas
25. Reactivity patterns and epitope mapping of CD34 panel mAbs
26. Expression of the Wilms' tumor gene (WT1) in normal hemopoiesis
27. Application of the nitrocellulose transfer technique and alkaline phosphatase conjugated anti-immunoglobulin for determination of the specificity of monoclonal antibodies to protein mixtures
28. High gradient magnetic cell separation with MACS
29. + cells into the myeloid lineage
30. An enzymatic method for the trace iodination of immunoglobulins and other proteins
31. Cell cycle analysis of a cell proliferation-associated human nuclear antigen defined by the monoclonal antibody Ki67
32. Resting and activated subsets of mouse multipotent hematopoietic stem cells
33. - subpopulation from mobilized peripheral blood
34. Expression and activity of P-glycoprotein, a multidrug efflux pump, in human hematopoietic stem cells
35. Expression and activity of the multidrug resistance P-glycoprotein in human peripheral blood lymphocytes
36. Altered surface membrane glycoproteins in vinca alkaloid-resistant human leukemic lymphoblasts
37. Functional and phenotypic characterization of cord blood and bone marrow subsets expressing Flt3 (CD135) receptor tyrosine kinase
38. Analysis of Tie receptor tyrosine kinase in haemopoietic progenitor and leukaemia cells
39. KDR receptor; a key marker defining hematopoietic stem cells
40. A novel five-transmembrane hematopoietic stem cell antigen; isolation, characterization, and molecular cloning
41. Molecular cloning and characterization of a novel receptor protein tyrosine kinase from human placenta
42. Identification of the KDR tyrosine kinase as a receptor for vascular endothelial cell growth factor
43. The Tie receptor tyrosine kinase is expressed by human hematopoietic progenitor cells and by a subset of megakaryocytic cells
44. Increased recruitment of hematopoietic progenitor cells underlies the ex vivo expansion potential of FLT3 ligand
45. The stem cell antigen CD34 functions as a regulator of hemopoietic cell adhesion
46. + independent mechanism
47. The sialomucin CD164 (MGC-24v) is an adhesive glycoprotein expressed by human hematopoietic progenitors and bone marrow stromal cells that serves as a potent negative regulator of hematopoiesis
48. CD164 monoclonal antibodies that block hemopoietic progenitor cell adhesion and proliferation interact with the first mucin domain of the CD164 receptor