Molecular biology's contribution to the understanding and treatment of Fanconi anemia;L'anémie de Fanconi à l'heure de la biologie moléculaire

Archives de Pediatrie

Volumn 8, Issue 8, 2001, Pages 853-860

  Mondovits, B ^a   Vermylen, C ^a   Brichard, B ^a   Cornu, G ^a  

^a CLINIQUES UNIVERSITAIRES SAINT LUC   (Belgium)

Author keywords

Bone marrow transplantation; Fanconi's anemia; Genetic heterogeneity; Genetics; Molecular biology

Indexed keywords

ALKYLATING AGENT; DNA; FANCONI ANEMIA GROUP A PROTEIN; FANCONI ANEMIA GROUP C PROTEIN; FANCONI ANEMIA GROUP F PROTEIN; FANCONI ANEMIA GROUP G PROTEIN; GENE PRODUCT; HLA ANTIGEN; OXYGEN; UNCLASSIFIED DRUG;

APOPTOSIS; AUTOSOMAL RECESSIVE DISORDER; BONE MARROW TRANSPLANTATION; CANCER; CELL CYCLE; CHROMOSOME BREAKAGE; DNA REPAIR; ENERGY METABOLISM; FANCONI ANEMIA; GENE FUNCTION; GENE THERAPY; GENETIC HETEROGENEITY; HLA MATCHING; HUMAN; MOLECULAR BIOLOGY; PANCYTOPENIA; PATHOGENESIS; REVIEW;

EID: 0034898952     PISSN: 0929693X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0929-693X(01)00530-9     Document Type: Short Survey

References (61)

1. Molecular biology of Fanconi anemia
2. The bone marrow failure syndromes
3. Fanconi's anaemia and its variability
4. Fanconi Anemia: Constitutional aplastic anemia
5. Diagnosis of Fanconi anemia in patients without congenital malformations: An international Fanconi anemia registry study
6. Fanconi anemia presenting unexpectedly in an adult kindred with no dysmorphic features
7. Erythropoiesis in Fanconi's anemia
8. Hematologic abnormalities in Fanconi anemia: An international Fanconi anemia registry study
9. The need for more accurate and timely diagnosis in Fanconi anemia: A report from the International Fanconi Anemia Registry
10. Fanconi's anemia, chromosome breakage studies in homozygotes and heterozygotes
11. Comparative evaluation of diepoxybutane sensitivity and cell cycle blockage in the diagnosis of Fanconi anemia
12. A simple diagnostic test for Fanconi anemia by flow cytometry
13. Fanconi anemia: Prenatal diagnosis in 30 foetuses at risk
14. Prenatal and postnatal diagnosis and carrier detection of Fanconi anemia by a cytogenetic method
15. Evidence for at least 4 Fanconi anaemia genes including FANCCC on chromosome 9
16. Classification of Fanconi anemia patients by complementation analysis: Evicence for a fifth genetic subtype
17. Evidence for at least eight Fanconi anemia genes
18. Cloning of cDNAs for Fanconi's anaemia by functional complementation
19. Expression cloning of a cDNA for the major Fanconi anemia gene, FANCA
20. Positional cloning of the Fanconi anaemia group A gene
21. Heterogeneous spectrum of mutations in the Fanconi anaemia group A
22. The Fanconi anaemia group G gene FANCG is identical with XRCC9
23. The Fanconi anaemia gene FANCF encodes a novel protein with homology to ROM
24. Microcell mediated chromosome transfer maps the Fanconi anaemia group D gene to chromosome 3p
25. The Fanconi anemia group E gene, FANCE, maps to chromosome 6p
26. Complementation groups: One or more per gene?
27. Association of complementation group and mutation type with clinical outcome in Fanconi anemia
28. Fanconi anaemia complementation groups in Germany and The Nederlands
29. Mutation analysis of the Fanconi anemia gene FANCC
30. Phenotypic consequences of mutations in the Fanconi anemia FANCC gene: An international Fanconi anemia registry study
31. The IVS4+4 A to T mutation of the Fanconi anemia gene FANCC is not associated with a severe phenotype in Japanese patients
32. Fanconi anemia: A pleotropic mutation with multiple cellular and developmental abnormalities
33. Localization of Fanconi anemia C protein to the cytoplasm of mammalian cells
34. The Fanconi anemia polypeptide FANCCC is localized to the cytoplasm
35. The Fanconi anaemia proteins, FANCA and FANCC, interact to form a nuclear complex
36. The Fanconi anemia pathways requires FANCA phosphorylation and FANCA-FANCC nuclear accumulation
37. Fanconi anemia proteins FANCA, FANCC, and FANCG/XRCC9 interact in a functional nuclear complex
38. The Fanconi anemia proteins FANCA and FANCG stabilize each other and promote the nuclear accumulation of the Fanconi anemia complex
39. The Fanconi anemia protein FANCF forms a nuclear complex with FANCA, FANCC and FANCG
40. Deregulated apoptosis is a hallmark of the Fanconi anemia syndrome
41. Molecular genetics and Fanconi anemia: New insights into old problems
42. Repression of Fanconi anemia gene (FANCC) expression inhibits growth of hematopoietic progenitor cell
43. Inactivation of the Fanconi anemia group C gene augments interferon-gamma-induced apoptotic responses in hematopoietic cells
44. Cytogenetic and flow cytometric studies of cells from patients with Fanconi anemia
45. Comparative evaluation of diepoxybutane sensitivity and call cycle blockage in the diagnosis of Fanconi anemia
46. The cell cycle of lymphocytes in Fanconi anemia
47. The effect of the Fanconi anemia polypeptide, FANCC, upon p53 induction and G2 checkpoint regulation
48. DNA cross-linker-induced G2/M arrest in group C Fanconi anemia lymphoblasts reflects normal checkpoint function
49. Oxygen-dependence of chromosomal aberrations in Fanconi's anemia
50. In vitro hypersensitivity to oxygen of Fanconi anemia (FA) cells is linked to ex vivo evidence for oxidative stress in FA homozygotes and heterozygotes
51. Fanconi anemia and leukemia: Tracking the genes
52. Cancer in relatives of patients with aplastic anemia
53. Evaluation of granulocyte-macrophage colony-stimulating FANCCtor for treatment of pancytopenia in children with Fanconi anemia
54. Prolonged administration of granulocyte colonystimulating factor (filgrastim) to patients with Fanconi anemia: A pilot study
55. Allogenic stem cell transplantation for Fanconi anemia. Severe Aplastic Anaemia Working Party of the EBMT and EUFAR
56. Outcome of 69 allogenic stem cell transplantations for Fanconi anemia using HLA-matched unrelated donors: A study on behalf of the European Group for Blood and Marrow Transplantation
57. Transplantation for Fanconi's anemia: Long-term follow-up of fifty patients transplanted from a sibling donor after low-dose cyclophosphamide and thoraco-abdominal irradiation for conditioning
58. Clinical outcome in recipients of cord blood transplant from related and unrelated donors
59. Phenotypic correction of Fanconi anemia in human hematopoietic cells with a recombinant adeno-associated virus vector
60. Functional correction of Fanconi anemia group A hematopoietic cells by retroviral gene transfer
61. A functionally active retrovirus vector for gene therapy in Fanconi anemia group C