Combined targeting of adenoviruses to integrins and epidermal growth factor receptors increases gene transfer into primary glioma cells and spheroids

Clinical Cancer Research

Volumn 7, Issue 3, 2001, Pages 641-650

  Grill, J ^a   Van Beusechem, V W ^a   Van Der Valk, P ^a   Dirven, C M F ^a   Leonhart, A ^a   Pherai, D S ^a   Haisma, H J ^a   Pinedo, H M ^a   Curiel, D T ^a   Gerritsen, W R ^a  

^a VU UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR; INTEGRIN; VIRUS VECTOR;

ADENOVIRUS; ADULT; AGED; ANTIGEN EXPRESSION; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; COXSACKIE VIRUS; CYTOMEGALOVIRUS; GENE TARGETING; GENE TRANSFER; GLIOMA CELL; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; PRIORITY JOURNAL; REPORTER GENE; SPHEROID CELL;

ADENOVIRIDAE; ANTIBODIES, BISPECIFIC; ANTIGENS, CD; BRAIN; BRAIN NEOPLASMS; CELL SEPARATION; ENTEROVIRUS; FLOW CYTOMETRY; GENE TRANSFER TECHNIQUES; GLIOBLASTOMA; GLIOMA; HUMANS; IMMUNOHISTOCHEMISTRY; INTEGRIN ALPHAV; INTEGRINS; LUCIFERASES; PROMOTER REGIONS (GENETICS); RECEPTOR, EPIDERMAL GROWTH FACTOR; SPHEROIDS, CELLULAR; TUMOR CELLS, CULTURED;

EID: 0034895056     PISSN: 10780432     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (37)

1. Adenoviral vectors: Prospects for gene delivery to the central nervous system
2. Gene therapy for gliomas: Molecular targets, adenoviral vectors, and oncolytic adenoviruses
3. Therapy of malignant brain tumors by intratumoral implantation of retroviral vector-producing cells
4. Treatment of progressive or recurrent pediatric malignant supratentorial brain tumors with herpes simplex virus thymidine kinase gene vector-producer cells followed by intravenous ganciclovir administration
5. Chronic brain inflammation and persistent herpes simplex virus 1 thymidine kinase expression in survivors of syngeneic glioma treated by adenovirus-mediated gene therapy: Implications for clinical trials
6. Coxsackie and adenovirus receptor (CAR)-dependent and major histocompatibility complex (MHC) class 1-independent uptake of recombinant adenoviruses into human tumor cells
7. Variability of adenovirus receptor density influences gene transfer efficiency and therapeutic response in head and neck cancer
8. The presence of human Coxsackievirus and adenovirus receptor is associated with efficient adenovirus-mediated transgene expression in human melanoma cell cultures
9. Loss of adenoviral receptor expression in human bladder cancer cells: A potential impact on the efficacy of gene therapy
10. Differential susceptibility of primary and established human glioma cells to adeno virus infection: Targeting via the epidermal growth factor receptor achieves fiber receptor-independent gene transfer
11. β-galactosidase gene transfer to human malignant glioma in vivo using replication-deficient retroviruses and adenoviruses
12. v-integrin does not correlate with adenovector targeting in vivo indicating anatomical vector barriers
13. Increased in vitro and in vivo gene transfer by adenovirus vectors containing chimeric fiber proteins
14. An adenovirus vector with genetically modified fibers demonstrates expanded tropism via utilization of a Coxsackievirus and adenovirus receptor-independent cell entry mechanism
15. Genetic targeting of adenoviral vectors
16. Targeted gene delivery by tropism-modified adenoviral vectors
17. Tumor-specific gene transfer via an adenoviral vector targeted to the pan-carcinoma antigen EpCAM
18. Targeting of adenoviral vectors through a bispecific single-chain antibody
19. 3 integrin
20. Characterization of integrin receptors in normal and neoplastic human brain
21. Antigenic heterogeneity of human anaplastic gliomas and glioma-derived cell lines defined by monoclonal antibodies
22. Intratumoral histologic heterogeneity of gliomas
23. Genetic heterogeneity in human astrocytomas: Spatial distribution of P16 and TP53 deletions in biopsies
24. Cellular and tumoral heterogeneity of EGFR gene amplification in human malignant gliomas
25. Epidermal growth factor receptor and labeling index are independent prognostic factors in glial tumor outcome
26. The in vitro biology of human brain tumors.
27. Multicellular tumor spheroids from human gliomas maintained in organ culture
28. Isolation of a common receptor for Coxsackie B viruses and adenoviruses 2 and 5
29. Radioimmunodetection of human glioma xenografts by monoclonal antibody to epidermal growth factor receptor
30. A dimeric bispecific miniantibody combines two specificities with avidity
31. The "adenobody" approach to viral targeting: Specific and enhanced adenoviral gene delivery
32. Selective gene delivery to head and neck cancer cells via an integrin targeted adenoviral vector
33. Long-term culture of organotypic multicellular glioma spheroids: A good culture model for studying gliomas
34. Targeting adenovirus
35. Basic fibroblast growth factor enhancement of adenovirus-mediated delivery of the herpes simplex virus thymidine kinase gene results in augmented therapeutic benefit in a murine model of ovarian cancer
36. A human cell line selected for resistance to adenovirus infection has reduced levels of the virus receptor
37. Retargeting to EGFR enhances adenovirus infection efficiency of squamous cell carcinoma