The effect of an increase in chain length on the mechanical properties of polyethylene glycols

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 46, Issue 1, 1998, Pages 31-38

  Al Nasassrah, Muhammed A ^a   Podczeck, Fridrun ^a   Newton, J Michael ^a  

^a UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

Critical stress intensity factor; Fracture mechanics; Fracture toughness; Mechanical strength of compacts; Polyethylene glycol; Strain energy release rate; Young's modulus

Indexed keywords

MACROGOL 10000; MACROGOL 20000; MACROGOL 35000; MACROGOL 4000; MACROGOL 6000; MACROGOL DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL STRUCTURE; DENSITY; ELASTICITY; ENERGY; FRACTURE; MOLECULAR WEIGHT; POROSITY; STATISTICAL ANALYSIS; SURFACE PROPERTY; TABLET COMPRESSION; TABLET FRIABILITY; TENSILE STRENGTH;

CHEMISTRY, PHARMACEUTICAL; PHARMACEUTIC AIDS; POLYETHYLENE GLYCOLS; TABLETS;

EID: 0032439635     PISSN: 09396411     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0939-6411(97)00151-3     Document Type: Article

References (23)

1. York P. Crystal engineering and particle design for the powder compaction process. Drug Dev. Ind. Pharm. 18:1992;677-721.
2. Newton J.M., Mashadi A.B., Podczeck F. The mechanical properties of an homologous series of benzoic acid esters. Eur. J. Pharm. Biopharm. 39:1993;153-157.
3. Al-angari A.A., Kennerley J.W., Newton J.M. The compaction properties of polyethylene glycols. J. Pharm. Pharmacol. 37:1985;151-153.
4. Kendall K. The impossibility of comminuting small particles by compression. Nature (London). 272:1978;710-711.
5. Mashadi A.B., Newton J.M. The characterisation of the mechanical properties of microcrystalline cellulose: a fracture mechanics approach. J. Pharm. Pharmacol. 39:1987;961-965.
6. P. Stanley, Mechanical strength testing of compacted powders, in: Postgraduate School, Production Process on Tablet Manufacture, The Pharmaceutical Society of Great Britain, London, 1985, pp. 123-144.
7. Podczeck F., Newton J.M. Determination of Young's modulus of different microcrystalline cellulose products. Pharmazie. 47:1992;387-388.
8. Brown W.F., Srawley J.E. Plane strain crack toughness testing of high strength metallic materials. ASTM Special Tech. Publ. 410:1967;1-65.
9. Podczeck F., Newton J.M. Determination of the critical stress intensity factor and the fracture toughness of different microcrystalline cellulose products. Pharmazie. 47:1992;462-463.
10. Roberts J.C., Powers J.M., Craig R.G. Fracture toughness and critical strain energy release rate of dental amalgam. J. Mater. Sci. 13:1978;965-971.
11. Fell J.T., Newton J.M. The tensile strength of lactose tablets. J. Pharm. Pharmacol. 20:1968;657-658.
12. Larhrib H., Wells J.I., Rubinstein M.H. Compressing polyethylene glycols: the effect of compression pressure and speed. Int. J. Pharm. 147:1997;199-205.
13. Lin C., Cham T. Compaction behaviour and tensile strength of heat-treated polyethylene glycols. Int. J. Pharm. 118:1995;169-179.
14. Craig D.Q.M., Newton J.M., Hill R.M. An investigation into the low-frequency dielectric response of polyethylene glycols. J. Mater. Sci. 28:1993;405-410.
15. Spriggs R.M. Expression for effect of porosity on elastic modulus of polycrystalline refractory materials, particularly aluminium oxide. J. Am. Ceram. Soc. 44:1961;628-629.
16. Larhrib H., Wells J.I., Rubinstein M.H., Ricart G. Characterization of PEGs using matrix-assisted laser desorption/ionisation mass spectrometry and other related techniques. Int. J. Pharm. 147:1997;187-198.
17. Ford J.L., Stewart A.F., Dubois J.-L. The properties of solid dispersions of indomethacin or phenylbutazone in polyethylene glycol. Int. J. Pharm. 28:1986;11-22.
18. A.J. Kinloch, R.J. Young, Fracture Behaviour of Polymers, Applied Science, London, 1983, pp. 44, 174-175.
19. Griffith A.A. The phenomena of rupture and flow in solids. Trans. R. Soc. A 221:1921;163-198.
20. Irwin G.R. Analysis of stresses and strains near the end of a crack traversing a plate. J. Appl. Mech. 24:1957;361-364.
21. Maugis D., Barquins M. Fracture mechanics and the adherence of viscoelastic bodies. J. Phys. D: Appl. Phys. 11:1978;1989-2023.
22. Ouchiyama N., Benbow J.J., Bridgewater J. On the fracture toughness of extrudates and its relationship to rates of bulk particle attrition. Powder Technol. 51:1987;103-114.
23. Mullier M.A., Seville J.P.K., Adams M.J. A fracture mechanics approach to the breakage of particle agglomerates. Chem. Eng. Sci. 42:1987;667-677.