Evaluation of critical binder properties affecting the compactibility of binary mixtures

Drug Development and Industrial Pharmacy

Volumn 27, Issue 3, 2001, Pages 181-194

  Mattsson, S ^a   Nystrom C ^a  

^a UPPSALA UNIVERSITY   (Sweden)

Author keywords

Binder; Compaction; Deformability; Porosity; Tablet; Tablet strength

Indexed keywords

BICARBONATE; MACROGOL 3000; MICROCRYSTALLINE CELLULOSE; POVIDONE; STARCH;

ARTICLE; POROSITY; SURFACE PROPERTY; TABLET COMPRESSION; TENSILE STRENGTH;

POROSITY; SODIUM BICARBONATE; TABLETS; TECHNOLOGY, PHARMACEUTICAL; TENSILE STRENGTH;

EID: 0035079770     PISSN: 03639045     EISSN: None     Source Type: Journal    
DOI: 10.1081/DDC-100000236     Document Type: Article

References (25)

1. Evaluation of the effect of addition of polyethylene glycols of differing molecular weights on the mechanical strength of sodium chloride and sodium bicarbonate tablets
2. Evaluation of strength-enhancing factors of a ductile binder in direct compression of sodium bicarbonate and calcium carbonate powders
3. Bonding surface area and bonding mechanism-two important factors for the understanding of powder compactability
4. The strength of compressed tablets. III. The relation of particle size, bonding and capping in tablets of sodium chloride, aspirin and hexamine
5. The effect of particle fragmentation and deformation on the interparticulate bond formation process during powder compaction
6. Tablet strength, porosity, elasticity and solid state structure of tablets compressed at high loads
7. Evaluation of a permeametry technique for surface area measurements of coarse particulate materials
8. Studies of direct compression of tablets. X. Measurement of tablet surface area by permeametry
9. Studies on direct compression of tablets. II. The influence of the particle size of a dry binder on the mechanical strength of tablets
10. Measurement of axial and radial tensile strength of tablets and their relation to capping
11. Determination of tablet strength by the diametral-compression test
12. Radial and axial tensile strength and strength variability of paracetamol tablets
13. Studies on direct compression of tablets. XVII. Porosity-pressure curves for the characterization of volume reduction mechanisms in powder compression
14. Heckel plots as indicators of elastic properties of pharmaceuticals
15. Prediction of the compression behaviour of powder mixtures by the heckel equation
16. Elastic recovery and surface area changes in compacted powder systems
17. Granulation in high speed mixers. Part 4: Effect of liquid saturation on agglomeration
18. The effect of water content on porosity and liquid saturation of extruded cylinders
19. Polyethylene glycol and dicalcium phosphate mixtures: Effect of tableting pressure
20. Compression speed on polyethylene glycol and dicalcium phosphate mixtures
21. Compaction properties of melt coated coarse drug particles
22. Studies on direct compression of tablets. XII. The consolidation and bonding properties of some pharmaceutical compounds and their mixtures with Avicel PH 105
23. A method of evaluating the mechanical characteristics of powders from the determination of the strength of compacts
24. Physicochemical comparison between microcrystalline cellulose and silicified microcrystalline cellulose
25. Improving DC with SMCC