The I1307K APC polymorphism: Prevalence in non-Ashkenazi Jews and evidence for a founder effect

Genetic Testing

Volumn 5, Issue 2, 2001, Pages 141-146

  Shtoyerman Chen, R ^a   Friedman, E ^a   Figer, A ^a   Carmel, M ^a   Patael, Y ^a   Rath, P ^a   Fidder, H H ^a   Bar Meir, S ^a   Theodor, L ^a  

^a SHEBA MEDICAL CENTER   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

APC PROTEIN; ISOLEUCINE; LYSINE;

ALLELE; ARTICLE; CANCER RISK; COLORECTAL CANCER; CONTROLLED STUDY; DENATURING GRADIENT GEL ELECTROPHORESIS; ETHNIC DIFFERENCE; FOUNDER EFFECT; GENE FREQUENCY; GENETIC ANALYSIS; GENETIC EPIDEMIOLOGY; GENETIC POLYMORPHISM; GENETIC RISK; HAPLOTYPE; HETEROZYGOTE; HUMAN; JEW; MAJOR CLINICAL STUDY; MISSENSE MUTATION; POLYMERASE CHAIN REACTION; POPULATION GENETICS; PREVALENCE; RESTRICTION MAPPING;

EID: 0034878803     PISSN: 10906576     EISSN: None     Source Type: Journal    
DOI: 10.1089/109065701753145628     Document Type: Article

References (23)

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3. The 185delAG BRCA1 mutation originated before the dispersion of Jews in the Diaspora and not limited to Ashkenazim
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5. The adenomatous polyp and the hereditary polyposis syndromes
6. Rapid diagnosis of beta-Thalassemia mutations in chinese by naturally and amplified created restriction sites
7. Two Mspl polymorphisms within the APC gene
8. Identification and characterization of the familial adenomatous polyposis gene
9. Somatic instability of the APC I1307K allele in colorectal neoplasia
10. Colorectal Tumors
11. Lessons from hereditary colorectal cancer
12. Two intragenic polymorphisms of the APC-gene detected by PCR and enzymatic digestion
13. Familial colorectal cancer in Ashkenazim due to a hypermutable tract in APC
14. Genetic analysis of an inherited predisposition to cancer in a family with a variable number of adenomatous polyps
15. Mutations of chromosome 5q21 genes in FAP and colorectal cancer patients
16. Common origin of the I1307K APC polymorphism in Ashkenazi and non-Ashkenazi Jews
17. The I1307K polymorphism of the APC gene in colorectal cancer
18. Prevalence of the I1307K APC gene variant in Israeli Jews of differing ethnic origin and risk for colorectal cancer
19. One of the two common mutations causing factor XI deficiency in Ashkenazi Jews is also prevalent in Iraqi Jews, who represent the ancient gene pool of Jews
20. A CA repeat 30-70 KB downstream from the adenomatous polyposis coli (APC) gene
21. CA repeat polymorphism at the D5S299 locus linked to adenomatous polyposis coli (APC)
22. Haplotype analysis of the founder APC I1307K allele in the Ashkenazim
23. The APC I1307K allele and cancer risk in a community-based study of Ashkenazi Jews