Comparison of the stability of some major cytochrome P450 and conjugation reactions in rat, dog and human hepatocyte monolayers

European Journal of Drug Metabolism and Pharmacokinetics

Volumn 26, Issue 1-2, 2001, Pages 37-45

  Ubeaud, Genevieve ^a,b   Schiller, Claus Ditter ^a   Hurbin, Fabrice ^a   Jaeck, Daniel ^c   Coassolo, Philippe ^a  

^a F HOFFMANN LA ROCHE LTD   (Switzerland)

^b UNIVERSITÉ DE STRASBOURG   (France)

^c HÔPITAL DE HAUTEPIERRE   (France)

Author keywords

Cell culture; Conjugation; Cytochrome P450; Hepatocytes; Metabolism; Oxidation

Indexed keywords

4 NITROPHENOL; CHLORZOXAZONE; CYTOCHROME P450; CYTOCHROME P450 1A; CYTOCHROME P450 2B; CYTOCHROME P450 2E1; CYTOCHROME P450 3A; ETHOXYRESORUFIN; GLUCURONOSYLTRANSFERASE; HERNIARIN; MIDAZOLAM; SULFOTRANSFERASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CONJUGATION; CONTROLLED STUDY; DEMETHYLATION; DOG; DRUG GLUCURONIDATION; DRUG HYDROXYLATION; ENZYME ACTIVITY; ENZYME STABILITY; EXPERIMENTAL MODEL; HUMAN; HUMAN CELL; HUMAN TISSUE; LIVER CELL; MALE; MONOLAYER CULTURE; NONHUMAN; RAT; SULFATION;

ANIMALS; CELL SURVIVAL; CELLS, CULTURED; CYTOCHROME P-450 ENZYME SYSTEM; DOGS; GLUCURONIDES; HEPATOCYTES; HUMANS; ISOENZYMES; MALE; NITROPHENOLS; RATS; SULFATES;

EID: 0034869809     PISSN: 03787966     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF03190374     Document Type: Article

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