Targeted adenovirus-mediated gene delivery to T cells via CD3

Journal of Virology

Volumn 71, Issue 10, 1997, Pages 7663-7669

  Wickham, Thomas J ^a   Lee, Gai M ^a   Titus, Julie A ^b   Sconocchia, Giuseppe ^b   Bakács, Tibor ^c   Kovesdi, Imre ^a   Segal, David M ^b  

^a GENVEC INC   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

^c NATIONAL INSTITUTE OF ONCOLOGY   (Hungary)

Author keywords

[No Author keywords available]

Indexed keywords

CD3 ANTIGEN;

ADENOVIRUS; ANTIBODY SPECIFICITY; ARTICLE; BONE MARROW PURGING; COMPLEX FORMATION; GENE DELETION; GENE TARGETING; GENE THERAPY; HUMAN; HUMAN CELL; INTERNALIZATION; PRIORITY JOURNAL; SEROTYPE; SIGNAL TRANSDUCTION; T LYMPHOCYTE ACTIVATION;

EID: 0030823638     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/jvi.71.10.7663-7669.1997     Document Type: Article

References (33)

1. Bai, M., B. Harfe, and P. Freimuth. 1993. Mutations that alter an Arg-Gly-Asp (RGD) sequence in the adenovirus type 2 penton base protein abolish its cell-rounding activity and delay virus reproduction in flat cells. J. Virol. 67:5198-5205.
2. Bergelson, J. M., J. A. Cunningham, G. Droguett, E. A. Kurt-Jones, A. Krithivas, J. S. Hong, M. S. Horwitz, R. L. Crowell, and R. W. Finberg. 1997. Isolation of a common receptor for coxsackie B viruses and adenoviruses 2 and 5. Science 275:1320-1323.
3. Buschle, M., M. Cotten, H. Kirlappos, K. Mechtler, G. Schaffner, W. Zauner, M. L. Birnstiel, and E. Wagner. 1995. Receptor-mediated gene transfer into human T lymphocytes via binding of DNA/CD3 antibody particles to the CD3 T cell receptor complex. Hum. Gene Ther. 6:753-761.
4. Cournoyer, D., and C. T. Caskey. 1993. Gene therapy of the immune system. Annu. Rev. Immunol. 11:297-329.
5. Douglas, J. T., B. E. Rogers, M. E. Rosenfeld, S. I. Michael, M. Feng, and D. T. Curiel. 1996. Targeted gene delivery by tropism-modified adenoviral vectors. Nat. Biotechnol. 14:1574-1578.
6. Fields, P. E., T. F. Gajewski, and F. W. Fitch. 1996. Blocked Ras activation in anergic CD4+ T cells. Science 271:1276-1279.
7. Fiering, S. N., M. Roederer, G. P. Nolan, D. R. Micklem, D. R. Parks, and L. A. Herzenberg. 1991. Improved FACS-Gal: flow cytometric analysis and sorting of viable eukaryotic cells expressing reporter gene constructs. Cytometry 12:291-301.
8. Freimuth, P. 1996. A human cell line selected for resistance to adenovirus infection has reduced levels of the virus receptor. J. Virol. 70:4081-4085.
9. Garrido, M. A., P. Perez, J. A. Titus, M. J. Valdayo, D. A. Winkler, S. A. Barbieri, J. R. Wunderlich, and D. M. Segal. 1990. Targeted cytotoxic cells in human peripheral blood lymphocytes. J. Immunol. 144:2891-2898.
10. 5 integrin is necessary for efficient adenovirus-mediated gene transfer in the human airway. J. Virol. 69:5951-5958.
11. Greber, U. F., M. Willetts, P. Webster, and A. Helenius. 1993. Stepwise dismantling of adenovirus 2 during entry into cells. Cell 75:477-486.
12. Hong, S. S., L. Karayan, J. Tournier, D. T. Curiel, and P. A. Boulanger. 1997. Adenovirus type 5 fiber knob binds to MHC class I α2 domain at the surface of human epithelial and B lymphoblastoid cells. EMBO J 16:2294-2306.
13. Horvath, J., and J. M. Weber. 1988. Nonpermissivity of human peripheral blood lymphocytes to adenovirus type 2 infection. J. Virol. 62:341-345.
14. vβ5 on human monocytes and T lymphocytes facilitates adenovirus-mediated gene delivery. J. Virol. 69:2257-2263.
15. Li, W., C. D. Whaley, A. Mondino, and D. L. Mueller. 1996. Blocked signal transduction to the ERK and JNK protein kinases in anergic CD4+ T cells. Science 271:1272-1275.
16. Naldini, L., U. Blomer, P. Gallay, D. Ory, R. Mulligan, F. H. Gage, I. M. Verma, and D. Trono. 1996. In vivo gene delivery and stable transduction of nondividing cells by a lentiviral vector. Science 272:262-267.
17. Philipson, L., K. Lonberg-Holm, and U. Pettersson. 1968. Virus-receptor interaction in an adenovirus system. J. Virol. 2:1064-1075.
18. Phillips, J. H., N. L. Warner, and L. L. Lanier. 1983. Correlation of biophysical properties and cell surface antigenic profile of Percoll gradient-separated human natural killer cells. Nat. Immun. Cell Growth. Regul. 3:73-86.
19. Reinherz, E. E., S. Meuer, K. A. Fitzgerald, R. E. Hussey, H. Levine, and S. F. Schlossman. 1982. Antigen recognition by human T lymphocytes is linked to surface expression of the T3 molecular complex. Cell 30:735-743.
20. Roelvink, P. W., I. Kovesdi, and T. J. Wickham. 1996. Comparative analysis of adenovirus fiber-cell interaction: adenovirus type 2 (Ad2) and Ad9 utilize the same cellular fiber receptor but use different binding strategies for attachment. J. Virol. 70:7614-7621.
21. Russell, S. J., and F.-L. Cosset. 1996. Targeting retrovirus entry. Gene Ther. 3:946-956.
22. Segal, D. M., and B. J. E. G. Bast. 1995. Production of bispecific antibodies, p. 2.13.11-12.13.16. In J. E. Coligan, A. M. Kruisbeek, D. H. Margulies, E. M. Shevach, and W. Strober (ed.), Current protocols in immunology. John Wiley & Sons, Inc., New York, N.Y.
23. Seth, P., U. Brinkmann, G. N. Schwartz, D. Katayose, R. Gress, I. Pastan, and K. Cowan. 1996. Adenovirus-mediated gene transfer to human breast tumor cells: an approach for cancer gene therapy and bone marrow purging. Cancer Res. 56:1346-1351.
24. Shenk, T. 1995. Group C adenoviruses as vectors for gene therapy, p. 43-54. In M. G. Kaplitt and A. D. Loewy (ed.), Viral vectors. Academic Press, San Diego, Calif.
25. Silver, L., and C. W. Anderson. 1988. Interaction of human adenovirus serotype 2 with human lymphoid cells. Virology 165:377-387.
26. Thimmappaya, B., C. Weinberger, R. J. Schneider, and T. Shenk. 1982. Adenovirus VAI RNA is required for efficient translation of viral mRNAs at late times after infection. Cell 31:543-551.
27. Tomko, R. P., R. Xu, and L. Philipson. 1997. HCAR and MCAR: the human and mouse cellular receptors for subgroup C adenoviruses and group B coxsackieviruses. Proc. Natl. Acad. Sci. USA 94:3352-3356.
28. Wattel, E., M. Vanrumbeke, M. A. Abina, N. Cambier, C. Preudhomme, H. Haddada, and P. Fenaux. 1996. Differential efficacy of adenoviral mediated gene transfer into cells from hematological cell lines and fresh hematological malignancies. Leukemia 10:171-174.
29. vβ6 in cell attachment to fibronectin. J. Biol. Chem. 269:6940-6948.
30. Wickham, T. J., M. E. Carrion, and I. Kovesdi. 1995. Targeting of adenovirus penton base to new receptors through replacement of its RGD motif with other receptor-specific peptide motifs. Gene Ther. 2:750-756.
31. vβ5 promote adenovirus internalization but not virus attachment. Cell 73:309-319.
32. Wickham, T. J., P. W. Roelvink, D. E. Brough, and I. Kovesdi. 1996. Adenovirus targeted to heparan-containing receptors increases its gene delivery efficiency to multiple cell types. Nat. Biotechnol. 14:1570-1573.
33. Wickham, T. J., D. M. Segal, P. W. Roelvink, M. E. Carrion, A. Lizonova, G. M. Lee, and I. Kovesdi. 1996. Targeted adenovirus gene transfer to endothelial and smooth muscle cells by using bispecific antibodies. J. Virol. 70:6831-6838.