Disproportionation of a model chromium(V) complex causes extensive chromium(III)-DNA binding in vitro

Chemical Research in Toxicology

Volumn 14, Issue 8, 2001, Pages 946-950

  Levina, A ^a   Lay, P A ^a   Dixon, N E ^b  

^a UNIVERSITY OF SYDNEY   (Australia)

^b AUSTRALIAN NATIONAL UNIVERSITY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

BUTYRIC ACID DERIVATIVE; CHROMIUM DERIVATIVE;

ANIMAL CELL; ARTICLE; CHEMICAL BINDING; CHEMICAL REACTION KINETICS; DNA ADDUCT; DNA BINDING; FISH; NONHUMAN; STOICHIOMETRY;

BINDING SITES; CARCINOGENS; CHROMIUM; DNA ADDUCTS; DNA DAMAGE; KINETICS; LIGANDS; OXIDATION-REDUCTION;

EID: 0034868663     PISSN: 0893228X     EISSN: None     Source Type: Journal    
DOI: 10.1021/tx010077g     Document Type: Article

References (31)

1. Chromium and carcinogenesis
2. Metabolism of the carcinogen chromate by cellular constituents
3. Chromium(V)-induced cleavage of DNA: Are chromium(V) complexes the active carcinogens in chromium(VI)-induced cancers?
4. Direct and hydrogen peroxide-induced chromium(V) oxidation of deoxyribose in single-stranded and double-stranded calf thymus DNA
5. Mechanisms of DNA damage by chromium(V) carcinogens
6. In vitro plasmid DNA cleavage by chromium(V) and -(IV) 2-hydroxycarboxylato complexes
7. Reactions of chromium(VI/V/TV) with bis(O-ethyl-L-cysteinato-N,S)zinc(II): A model for the action of carcinogenic chromium on zinc-finger proteins
8. Reductive metabolism of Cr(VI) by cysteine leads to the formation of binary and ternary Cr-DNA adducts in the absence of oxidative DNA damage
9. Non-oxidative mechanisms are responsible for the induction of mutagenesis by reduction of Cr(VI) with cysteine: Role of ternary DNA adducts in Cr(III)-dependent mutagenesis
10. Pathways in the chromium(VI)-mediated formation of DNA lesions: A review
11. Chromium cross-links glutathione and cysteine to DNA
12. Reduction of chromium(VI) by ascorbate leads to chromium-DNA binding and DNA strand beaks in vitro
13. Synthesis of stable chromium(V) complexes of tertiary hydroxy acids
14. Electrochemistry of the quasi-reversible bis[2-ethyl-2-hydroxybutanoato(2-)]-oxochromate-(V) and -(IV) and bis[2-hydroxy-2-methylbutanoato-(2-)]oxochromate-(V) and -(IV) redox couples and the crystal and molecular structure of sodium bis[2-ethyl-2-hydroxybutanoato-(2-)]-oxochromate(V) sesquihydrate
15. Studies on the genotoxicity of chromium: From the test tube to the cell
16. Chromium(V) oxidation of organic compounds
17. Disproportionation and nuclease activity of bis[2-ethyl-2-hydroxybutanoato(2-)]oxochromate(V) in neutral aqueous solutions
18. Permeability, cytotoxicity, and genotoxicity of chromium(V) and chromium(VI) complexes in V79 Chinese hamster lung cells
19. Kinetics and mechanism of chromium(VI) reduction to chromium(III) by L-cysteine in neutral aqueous solutions
20. 3+ complexes with DNA
21. 4
22. Mapping the active sites of 3-phosphoglycerate kinase and glycerol kinase with menoammine chromium(III) ATP
23. 2- as a model for Cr(III)-DNA adducts
24. A comparative study of calf thymus DNA binding to Cr(III) and Cr(VI) ions. Evidence for the guanine N-7-chromium-phosphate chelate formation
25. On the role of trivalent chromium in chromium genotoxicity
26. Defining conditions for the efficient in vitro cross-linking of proteins to DNA by chromium(III) compounds
27. Early stages of the hydrolysis of chromium(III) in aqueous solutions. 1. Characterization of a tetrameric species
28. Microsomal reduction of the carcinogen chromate produces chromium(V)
29. Low-frequency electron paramagnetic resonance investigation on metabolism of chromium(VI) by whole live mice