A duplicated HNF-3 binding site in the CYP2H2 promoter underlies the weak phenobarbital induction response

International Journal of Biochemistry and Cell Biology

Volumn 33, Issue 11, 2001, Pages 1080-1093

  Davidson, Benjamin P ^a   Dogra, Satish C ^a   May, Brian K ^a  

^a UNIVERSITY OF ADELAIDE   (Australia)

Author keywords

Chicken; CYP2H1; CYP2H2; HNF 3; Phenobarbital

Indexed keywords

CYTOCHROME P450 2H1; CYTOCHROME P450 2H2; CYTOCHROME P450 ISOENZYME; DNA; HEPATOCYTE NUCLEAR FACTOR 3; MESSENGER RNA; PHENOBARBITAL; SEDATIVE AGENT; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; BINDING SITE; CHICK EMBRYO; CONTROLLED STUDY; DNA FLANKING REGION; DNA FOOTPRINTING; DNA SEQUENCE; EMBRYO; ENHANCER REGION; GENE INDUCTION; GENE SEQUENCE; IN VITRO STUDY; LIVER CELL; NONHUMAN; PROMOTER REGION; SEQUENCE ANALYSIS; SEQUENCE HOMOLOGY; STEADY STATE;

ANIMALS; BASE SEQUENCE; CELL NUCLEUS; CELLS, CULTURED; CHICK EMBRYO; CLONING, MOLECULAR; CYTOCHROME P-450 ENZYME SYSTEM; DNA FOOTPRINTING; ELECTROPHORETIC MOBILITY SHIFT ASSAY; GENE EXPRESSION REGULATION; HEPATOCYTES; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; PHENOBARBITAL; PROMOTER REGIONS (GENETICS); REPETITIVE SEQUENCES, NUCLEIC ACID; RESPONSE ELEMENTS; SEQUENCE DELETION; TRANSCRIPTION FACTORS; TRANSFECTION;

GALLUS GALLUS;

EID: 0034866677     PISSN: 13572725     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1357-2725(01)00076-0     Document Type: Article

References (22)

1. The nuclear orphan receptor CAR-retinoid X receptor heterodimer activates the phenobarbital-responsive enhancer module of the CYP2B gene
2. Phenobarbital-responsive nuclear translocation of the receptor CAR in the induction of the CYP2B gene
3. The nuclear receptor CAR mediates specific xenobiotic induction of drug metabolism
4. Induction of delta-aminolevulinate synthase and cytochrome P-450 hemoproteins in hepatocyte culture. Effect of glucose and hormones
5. Transcriptional regulation of the chicken CYP2H1 gene
6. Sequence of a chicken phenobarbital-inducible cytochrome P450 cDNA: Regulation of two P450 mRNAs transcribed from different genes
7. The cDNA and protein sequence of a phenobarbital-induced chicken cytochrome P-450
8. Isolation and characterisation of genomic clones for two chicken phenobarbital-inducible cytochrome P-450 genes
9. Phenobarbital-induced activation of CYP2H1 and 5-aminolevulinate synthase genes in chick embryo hepatocytes is blocked by an inhibitor of protein phosphorylation
10. Liver-enriched transcription factors HNF-1, HNF-3 and C/EBP are major contributors to the strong activity of the chicken CYP2H1 promoter in chick embryo hepatocytes
11. Transcriptional activation of cytochrome P450 genes by different classes of chemical inducers
12. Analysis of a phenobarbital-responsive enhancer region located in the 5′ flanking region of the chicken CYP2H1 gene: Identification and characterisation of functional protein binding sites
13. Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells
14. Two distinct enhancers with different cell specificities coexist in the regulatory region of polyoma
15. Tissue-specific in vitro transcription from the mouse albumin promoter
16. Factors involved in control of tissue-specific expression of albumin gene
17. Sequencing end-labelled DNA with base-specific chemical cleavages
18. The DNA-binding specificity of the hepatocyte nuclear factor 3/forkhead domain is influenced by amino acid residues adjacent to the recognition helix
19. A conserved nuclear receptor consensus sequence (DR-4) mediates transcriptional activation of the chicken CYP2H1 gene by phenobarbital in a hepatoma cell line
20. Multiple hepatocyte-enriched nuclear factors function in the regulation of the transthyretin and α1-antitrypsin genes
21. Hepatocyte nuclear factor-3α promoter regulation involves recognition by cell-specific factors, thyroid transcription factor-1, and autoactivation
22. Orphan nuclear receptors constitutive anderostane receptor and pregnane X receptor share xenobiotic and steroid ligands