The shortcomings of the GLAST knockout mouse [2]

Journal of Bone and Mineral Research

Volumn 16, Issue 9, 2001, Pages 1729-1730

  Skerry, T ^a   Genever, P ^a   Taylor, A ^a   Dobson, K ^a   Mason, D ^a   Suva, L ^a  

^a UNIVERSITY OF YORK   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

2 AMINO 5 PHOSPHONOVALERIC ACID; DIZOCILPINE; GLUTAMATE RECEPTOR; N METHYL DEXTRO ASPARTIC ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; AMINO ACID RECEPTOR BLOCKING AGENT; AMINO ACID RECEPTOR STIMULATING AGENT; DIZOCILPINE MALEATE; GLUTAMATE TRANSPORTER; GLUTAMIC ACID; N METHYLASPARTIC ACID;

ANIMAL CELL; ANIMAL MODEL; CELL CULTURE; KNOCKOUT MOUSE; LETTER; MOUSE; NONHUMAN; OSSIFICATION; OSTEOCLAST; OSTEOLYSIS; SIGNAL TRANSDUCTION; ANIMAL; BONE DEVELOPMENT; CYTOLOGY; DRUG EFFECT; GENETICS; MOUSE MUTANT; NOTE; OSTEOBLAST; PHYSIOLOGY;

AMINO ACID TRANSPORT SYSTEM X-AG; ANIMALS; DIZOCILPINE MALEATE; EXCITATORY AMINO ACID AGONISTS; EXCITATORY AMINO ACID ANTAGONISTS; GLUTAMIC ACID; MICE; MICE, KNOCKOUT; N-METHYLASPARTATE; OSTEOBLASTS; OSTEOGENESIS;

MLCS; MLOWN;

EID: 0034865471     PISSN: 08840431     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Letter

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2. Mechanically regulated expression of a neural glutamate transporter in bone: A role for excitatory amino acids as osteotropic agents?
3. Glutamate receptors are expressed by bone cells and are involved in bone resorption
4. Expression of an NMDA type receptor by human and rat osteoblasts and osteoclasts suggests a novel glutamate signaling pathway in bone
5. Expression of a functional N-methyl-D-aspartate-type glutamate receptor by bone marrow megakaryocytes
6. Functional characterization of N-methyl-D-aspartic acid-gated channels in bone cells
7. The glutamate receptor antagonist MK801 modulates bone resorption in vitro by a mechanism predominantly involving osteoclast differentiation
8. Active NMDA glutamate receptors are expressed by mammalian osteoclasts
9. Specific antagonists of NMDA receptors prevent osteoclast sealing zone formation required for bone resorption
10. Bone formation/resorption and osteoblast/adipocyte plasticity mediated by AMPA/kainate glutamate receptors in vitro and in vivo
11. 2+-sensing function of the metabotropic glutamate receptors
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13. Constitutive glutamate signalling is necessary for bone formation and activates the transcription factor AP1
14. Motor discoordination and increased susceptibility to cerebellar injury in GLAST mutant mice
15. Enhanced long-term potentiation and impaired learning in mice with mutant postsynaptic density-95 protein
16. Amygdala-kindled and pentylenetetrazole-induced seizures in glutamate transporter GLAST-deficient mice