Tick-borne Langat/mosquito-borne dengue flavivirus chimera, a candidate live attenuated vaccine for protection against disease caused by members of the tick-borne encephalitis virus complex: Evaluation in rhesus monkeys and in mosquitoes

Journal of Virology

Volumn 75, Issue 17, 2001, Pages 8259-8267

  Pletnev, A G ^a   Bray, M ^a   Hanley, K A ^a   Speicher, J ^a   Elkins, R ^a  

^a NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LIVE VACCINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHIMERA; CONTROLLED STUDY; DENGUE VIRUS; FEMALE; IMMUNE RESPONSE; IMMUNITY; IMMUNOGENICITY; MALE; MOSQUITO; MOUSE; NONHUMAN; PRIORITY JOURNAL; RHESUS MONKEY; TICK BORNE DISEASE; TICK BORNE ENCEPHALITIS FLAVIVIRUS; VIREMIA; VIRUS ATTENUATION; VIRUS TRANSMISSION;

ANIMALS; ANTIBODIES, VIRAL; CELLS, CULTURED; CERCOPITHECUS AETHIOPS; CULICIDAE; DENGUE; DENGUE VIRUS; ENCEPHALITIS VIRUSES, TICK-BORNE; ENCEPHALITIS, TICK-BORNE; IMMUNIZATION, PASSIVE; MACACA MULATTA; MICE; MICE, INBRED BALB C; MICE, SCID; RECOMBINANT FUSION PROTEINS; VACCINATION; VACCINES, ATTENUATED; VACCINES, SYNTHETIC; VERO CELLS; VIRAL VACCINES; VIRUS REPLICATION;

EID: 0034864644     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.75.17.8259-8267.2001     Document Type: Article

References (39)

1. Construction of intertypic chimeric dengue viruses by substitution of structural protein genes
2. Monkeys immunized with intertypic chimeric dengue viruses are protected against wild-type virus challenge
3. Infectious cDNA clones of Langat tick-borne flavivirus that differ from their parent in peripheral neurovirulence
4. Yellow fever/Japanese encephalitis chimeric viruses: Construction and biological properties
5. Further studies on antigenic relationships among the viruses of the group B tick-borne complex
6. Immunogenicity, genetic stability, and protective efficacy of a recombinant, chimeric yellow fever-Japanese encephalitis virus (ChimeriVax-JE) as a live, attenuated vaccine candidate against Japanese encephalitis
7. Recombinant chimeric yellow fever-dengue type 2 virus is immunogenic and protective in nonhuman primates
8. Dengue and Chikungunya virus infection in man in Thailand, 1962-1964. III. Clinical, epidemiologic and virologic observations on disease in non-indigenous white persons
9. Chimeric dengue type 2 (vaccine strain PDK-53)/dengue type 1 virus as a potential candidate dengue type I virus vaccine
10. Experience in the study of a live vaccine made from the TP21 strain of Malayan Langat virus
11. Virulence of a live dengue virus vaccine candidate: A possible new marker of dengue virus attenuation
12. An improved micromethod for infectivity assays and neutralization test of dengue viruses
13. Spontaneous and engineered deletions in the 3′ noncoding region of tick-borne encephalitis virus: Construction of highly attenuated mutants of a flavivirus
14. Attenuation of tick-borne encephalitis virus by structure-based site-specific mutagenesis of a putative flavivirus receptor binding site
15. Predominance of HLA-restricted cytotoxic T-lymphocyte responses to serotype-cross-reactive epitopes on nonstructural proteins following natural secondary dengue virus infection
16. Dengue type 4 virus mutants containing deletion in the 3′ noncoding region of the RNA genome: Analysis of growth restriction in cell culture and altered viremia pattern and immunogenicity in rhesus monkeys
17. Flaviviruses
18. Mutagenesis of the N-linked glycosylation sites of the yellow fever virus NS1 protein: Effects on virus replication and mouse neurovirulence
19. Experimental infection of monkeys with Langat virus. I. Comparison of viremia following peripheral inoculation of Langat and Japanese encephalitis viruses
20. Histological studies of the monkey neurovirulence of group B arboviruses. IV. Evaluation of an attenuated strain (E5) of Langat virus
21. Definition of the region on NS3 which contains multiple epitopes recognized by dengue virus serotype-cross-reactive and flavivirus-cross-reactive, HLA-DPw2-restricted CD4 T cell clones
22. Construction and characterization of tick-borne encephalitis/dengue type 4 viruses
23. Chimeric tick-borne encephalitis and dengue type 4 viruses: Effects of mutations on neurovirulence in mice
24. Attenuation of the Langat tick-borne flavivirus by chimerization with mosquito-borne flavivirus dengue type 4
25. Chimeric Langat/dengue viruses protect mice from heterologous challenge with the highly virulent strains of tick-borne encephalitis virus
26. Vaccination of human volunteers against Russian spring-summer (RSS) virus complex with attenuated Langat E5 virus
27. Immunization of mice against Russian spring-summer virus complex and monkeys against Powassan virus with attenuated Langat E5 virus
28. The use of mosquitoes to detect and propagate dengue viruses
29. The use of Toxorhynchites mosquitoes to detect and propagate dengue and other arboviruses
30. Dengue viruses
31. Naked DNA vaccines expressing the prM and E genes of Russian spring summer encephalitis virus and Central European encephalitis virus protect mice from homologous and heterologous challenge
32. Dengue-2 vaccine: Viremia and immunoresponses in rhesus monkeys
33. A virus resembling Russian spring-summer encephalitis virus from an Ixodid in Malaya
34. Effect of size and geographic origin of Aedes aegypti on oral infection with dengue-2 virus
35. A chick embryo attenuated strain (TP21 E5) of Langat virus. I. Virulence of the virus for mice and monkeys
36. Chimeric yellow fever/dengue virus as a candidate dengue vaccine: Quantitation of the dengue virus-specific CD8 T-cell response
37. Dengue viremia titer, antibody response pattern, and virus serotype correlate with disease severity
38. Evaluation of Toxorhynchites splendens (Diptera: Culicidae) as a bioassay host for dengue viruses
39. Identification of specific nucleotide sequences within the conserved 3′-SL in the dengue type 2 virus genome required for replication