Differentiated keratinocytes are responsible for TNF-α regulated production of macrophage inflammatory protein 3α/CCL20, a potent chemokine for Langerhans cells

Journal of Dermatological Science

Volumn 27, Issue 2, 2001, Pages 130-139

  Tohyama, Mikiko ^a   Shirakara, Yuji ^a   Yamasaki, Kenshi ^a   Sayama, Koji ^a   Hashimoto, Koji ^a  

^a EHIME UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Keratinocyte; Langerhans cell; MIP 3 CCL20; TNF

Indexed keywords

CHEMOKINE; GAMMA INTERFERON; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 6; MACROPHAGE INFLAMMATORY PROTEIN; MACROPHAGE INFLAMMATORY PROTEIN 3ALPHA; MESSENGER RNA; PROTEIN; PROTEIN CCL20; TRANSFORMING GROWTH FACTOR BETA1; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL CULTURE; CELL DIFFERENTIATION; CELL MIGRATION; CHEMOTAXIS; CONTROLLED STUDY; CULTURE MEDIUM; DENDRITIC CELL; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION; HUMAN; HUMAN CELL; IMMUNITY; IMMUNOFLUORESCENCE; KERATINOCYTE; LANGERHANS CELL; MOUSE; NONHUMAN; ORGAN CULTURE; PRIORITY JOURNAL; PROTEIN SECRETION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SKIN; SUPERNATANT; WESTERN BLOTTING;

CELL DIFFERENTIATION; CELLS, CULTURED; CHEMOKINES, CC; CHEMOTAXIS; GENE EXPRESSION REGULATION; HUMANS; KERATINOCYTES; MACROPHAGE INFLAMMATORY PROTEINS; ORGAN CULTURE TECHNIQUES; RECEPTORS, CHEMOKINE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SKIN; SKIN PHYSIOLOGY; TRANSCRIPTION, GENETIC; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0034857765     PISSN: 09231811     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0923-1811(01)00127-X     Document Type: Article

References (36)

1. Chemokines and cell migration in secondary lymphoid organs
2. Cytokines and chemokines in the initiation and regulation of epidermal Langerhans cell mobilization
3. Human recombinant monocyte chemotactic protein and other c-c chemokines bind and induce directional migration of dendritic cells in vitro
4. The role of chemokines in the regulation of dendritic cell trafficking
5. Regulation of dendritic cell trafficking: a process that involves the participation of selective chemokines
6. MCP-1 mRNA expression in basal keratinocytes of psoriasis lesions
7. In vivo production of cytokines and β (C-C) chemokines in human recurrent herpes simplex lesions-do herpes simplex virus-infected keratinocytes contribute to their production?
8. Upregulation of RANTES in psoriatic keratinocytes: a possible pathogenic mechanism for psoriasis
9. Novel lymphocyte-specific CC chemokine and their receptors
10. Molecular cloning of a novel human CC chemokine liver and activation regulated chemokine (LARC) expressed in liver: chemotactic activity for lymphocytes and gene localization on chromosome 2
11. Identification through bioinformatics of two new macrophage proinflammatory human chemokines MIP-3α and MIP-3β
12. Cloning and characterization of exodus, a novel β-chemokine
13. Identification of CCR6, the specific receptor for a novel lymphocyte-directed CC chemokine LARC
14. STRL22 is a receptor for the CC chemokine MIP-3α
15. CCR6, a CC chemokine receptor that interacts with macrophage inflammatory protein 3α and is highly expressed in human dendritic cells
16. Selective recruitment of immature dendritic cells by distinct chemokines expressed in different anatomic sites
17. Cutting edge: immature dendritic cells generated form monocytes in the presence of TGF-β1 express functional C-C chemokine receptor 6
18. Macrophage inflammatory protein 3α is involved in the constitutive trafficking of epidermal Langerhans cells
19. CC-chemokine receptor 6 is expressed on diverse memory subsets of T cells and determines responsiveness to macrophage inflammatory protein 3α
20. Up-regulation of macrophage inflammatory protein-3α/CCL20 and CC chemokine receptor 6 in psoriasis
21. Inducible expression of a CC chemokine liver- and activation-regulated chemokine (LARC)/macrophage inflammatory protein (MIP)-3alpha/CCL20 by epidermal keratinocytes and its role in atopic dermatitis
22. Migration of Langerhans cells in an in vitro organ culture system: IL-6 and TNF-α are partially responsible for migration into the epidermis
23. In vivo activation of Langerhans cells and dendritic epidermal T cells in the elicitation phase of murine contact hypersensitivity
24. New techniques for the in vitro culture or human keratinocytes and perspectives on their use for grafting of patients with extensive burns
25. A lymphocyte-specific CC chemokine, secondary lymphoid tissue chemokine (SLC), is a highly efficient chemoattractant for B cells and activated T cells
26. Early molecular events in the induction phase of contact sensitivity
27. Novel responses of human skin to intradermal recombinant granulocyte/macrophage colony-stimulating factor: Langerhans cell recruitment, keratinocyte growth and enhanced wounding healing
28. A role for endogenous transforming growth factor β1 in Langerhans cell biology: The skin transforming growth factor β1 null mice is devoid of epidermal Langerhans cells
29. Localization of tumor necrosis factor-alpha (TNF-alpha) and its receptors in normal and psoriatic skin: epidermal cells express the 55-kD but not the 75-kD TNF receptor
30. In situ expression and serum levels of tumor necrosis factor alpha receptors in patients with lichen planus
31. Differential expression of fos and jun family members c-fos, fosB, Fra-1, Fra-2, d-jun, junB and junD during human epidermal keratinocyte differentiation
32. Alterations in NF-κB function in transgenic epithelial tissue demonstrate a growth inhibitory role for NF-κB
33. Beta-defensins: linking innate and adaptive immunity through dendritic and T cell CCR6
34. A peptide antibiotic from human skin
35. Human beta defensin 1 and human beta defensin 2 peptides are expressed in normal human skin and upregulated following wounding
36. Adhesion of epidermal Langerhans cells to keratinocytes mediated by E-cadherin