Glutathione peroxidase-1 gene knockout on body antioxidant defense in mice

BioFactors

Volumn 14, Issue 1-4, 2001, Pages 93-99

  Xin Gen Lei, ^a  

^a Department of Obstetrics Gynecology   (United States)

Author keywords

Antioxidant; Gene knockout; Glutathione peroxidase; Mice; Selenium

Indexed keywords

ALANINE AMINOTRANSFERASE; ALPHA TOCOPHEROL; ANTIOXIDANT; DIQUAT; GLUTATHIONE PEROXIDASE; ISOPROSTANE DERIVATIVE; PARAQUAT; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; SELENIUM; SELENOPROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIOXIDANT ACTIVITY; BODY WEIGHT; CONFERENCE PAPER; CONTROLLED STUDY; ENZYME ACTIVITY; GENE EXPRESSION; KNOCKOUT MOUSE; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; SURVIVAL RATE;

ANIMALIA;

EID: 0034852563     PISSN: 09516433     EISSN: None     Source Type: Journal    
DOI: 10.1002/biof.5520140113     Document Type: Conference Paper

References (38)

1. Effect of selenium deficiency and glutathione-modulating agents on diquat toxicity and lipid peroxidation in rats
2. Glutathione peroxidase protects mice from viral-induced myocarditis
3. Distribution of selenium and glutathione peroxidase in the rat
4. Tissue-specific functions of individual glutathione peroxidase
5. Liver necrosis and lipid peroxidation in the rat as the result of paraquat and diquat administration
6. Superoxide- and singlet oxygen-catalyzed lipid peroxidation as a possible mechanism for paraquat (methyl viologen) toxicity
7. Knockout of cellular glutathione peroxidase affects selenium-dependent parameters similarly in mice fed adequate and excessive dietary selenium
8. Impacts of cellular glutathione peroxidase (GPX1) knockout on mouse susceptibility to moderate oxidative stress
9. Selenium-dependent cellular glutathione peroxidase protects mice against a pro-oxidant-induced oxidation of NADPH, NADH, lipid, and protein
10. Overexpression of cellular glutathione peroxidase did not affect expression of plasma glutathione peroxidase or phospholipid hydroperoxide glutathione peroxidase in mice offered diets adequate or deficient in selenium
11. Cellular glutathione peroxidase knockout mice express normal levels of selenium-dependent plasma and phospholipid hydroperoxide glutathione peroxidases in various tissues
12. Cellular glutathione peroxidase is the mediator of body selenium to protect against paraquat lethality in transgenic mice
13. High levels of dietary vitamin E do not replace cellular glutathione peroxidase in protecting mice from oxidative stress
14. Expression, characterization, and tissue distributions of a new cellular selenium-dependent glutathione peroxidase, GSHPx-G1
15. Protection against acute paraquat toxicity by dietary selenium in chick
16. Mice with a homozygous null mutation for the most abundant glutathione peroxidase, Gpx1, show increased susceptibility to the oxidative stress-inducing agents paraquat and hydrogen peroxide
17. Mitochondrial oxidative stress in mice lacking the glutathione peroxidase-1 gene
18. Selenium, the element of the moon, in life on earth
19. Glutathione peroxidase: A selenoenzyme
20. Knockout of cellular glutathione peroxidase gene renders mice susceptible to diquat-induced oxidative stress
21. Cellular glutathione peroxidase protects mice against lethal oxidative stress induced by various doses of diquat
22. Mice deficient in cellular glutathione peroxidase develop normally and show no increased sensitivity to hyperoxia
23. Chronic brain oxidation in a glutathione peroxidase knockout mouse model results in increased resistance to induced epileptic seizures
24. Red cells from glutathione peroxidase-1-deficient mice have nearly normal defenses against exogenous peroxides
25. Mice deficient in cellular glutathione peroxidase show increased vulnerability to malonate, 3-nitropropionic acid, and 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine
26. Antioxidative impacts of glutathione peroxidase-1 gene knockout in mice, Selenum 2000
27. Glutathione peroxidase and phospholipid hydroperoxide glutathione peroxidase are differentially regulated by dietary selenium
28. Deliberations and evaluations of the approaches, endpoints and paradigms for selenium and iodine dietary recommendations
29. Regulation of cardiomyocyte apoptosis in ischemic reperfused mouse heart by glutathione peroxidase
30. Overexpression of seleno-glutathione peroxidase by gene transfer enhances the resistance of T47D human breast cells to clastogenic oxidants
31. Preferential resistance of dopaminergic neurons to the toxicity of glutathione depletion is independent of cellular glutathione peroxidase and is mediated by tetrahydrobiopterin
32. Peroxide-induced damage in lenses of transgenic mice with deficient and elevated levels of glutathione peroxidase
33. Selenium: Biochemical role as a component of glutathione peroxidase
34. Mechanism of paraquat toxicity in lung and its relevance to treatment
35. 2 by the mouse lens
36. Glutathione peroxidase protects cultured mammalian cells from the toxicity of adriamycin and paraquat
37. Glutathione peroxidase knockout mice are susceptible to myocardial ischemia reperfusion injury
38. Enhanced N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine toxicity in mice deficient in CuZn-superoxide dismutase or glutathione peroxidase