A cofactor-dependent phosphoglycerate mutase homolog from Bacillus stearothermophilus is actually a broad specificity phosphatase

Protein Science

Volumn 10, Issue 9, 2001, Pages 1835-1846

  Rigden, Daniel J ^a   Bagyan, Irina ^b   Lamani, Ejvis ^c   Setlow, Peter ^b   Jedrzejas, Mark J ^c,d  

^a EMBRAPA RECURSOS GENÉTICOS E BIOTECNOLOGIA   (Brazil)

^b UNIVERSITY OF CONNECTICUT HEALTH CENTER   (United States)

^c University of Alabama at Birmingham   (United States)

^d CHILDREN S HOSPITAL OAKLAND RESEARCH INSTITUTE   (United States)

Author keywords

Bacillus; Functional genomics; Molecular modeling; Phosphatase; Phosphoglycerate mutase homolog; Structure function relationship; Structure prediction

Indexed keywords

PHOSPHATASE; PHOSPHOGLYCERATE MUTASE;

ARTICLE; BACILLUS SUBTILIS; CRYSTAL STRUCTURE; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME ASSAY; ENZYME LOCALIZATION; ENZYME SPECIFICITY; GENE OVEREXPRESSION; GENE SEQUENCE; GENOME; GEOBACILLUS STEAROTHERMOPHILUS; MOLECULAR MODEL; NONHUMAN; NUCLEOTIDE SEQUENCE; PHYLOGENY; PRIORITY JOURNAL; SEQUENCE ANALYSIS; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS;

AMINO ACID SEQUENCE; BACILLUS STEAROTHERMOPHILUS; BACILLUS SUBTILIS; COENZYMES; CONSENSUS SEQUENCE; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MULTIENZYME COMPLEXES; PHOSPHOGLYCERATE MUTASE; PHOSPHOPROTEIN PHOSPHATASE; PHYLOGENY; PROTEIN CONFORMATION; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY, AMINO ACID; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY;

BACILLUS SUBTILIS; BACTERIA (MICROORGANISMS); GEOBACILLUS STEAROTHERMOPHILUS; POSIBACTERIA;

EID: 0034848174     PISSN: 09618368     EISSN: None     Source Type: Journal    
DOI: 10.1110/ps.15701     Document Type: Article

References (60)

1. Basic local alignment search tool
2. Gapped BLAST and PSI-BLAST: A new generation of protein database search programs
3. Assay of inorganic phosphate, total phosphate and phosphatases
4. Phosphotyrosine as a substrate of acid and alkaline phosphatases
5. The ENZYME database in 2000
6. ALSCRIPT, a tool to format multiple sequence alignments
7. Model building by comparison at CASP3: Using expert knowledge and computer automation
8. High-resolution structure of the phosphohistidine-activated form of Escherichia coli cofactor-dependent phosphoglycerate mutase
9. Analysis of the Escherichia coli genome VI: DNA sequence of the region from 92.8 through 100 minutes
10. 2+ and is pH sensitive
11. PHYLIP - Phylogeny Inference Package (version 3.2)
12. Hybrid fold recognition: Combining sequence derived properties with evolutionary information
13. Activation and germination characteristics observed in endospores of thermophilic strains of Bacillus
14. The phosphoglycerate mutases
15. The two analagous phosphoglycerate mutases of Escherichia coli
16. ParaMEME: A parallel implementation and a web interface for a DNA and protein motif discovery tool
17. Active site phosphohistidine peptides from red cell bisphosphoglycerate synthase and yeast phosphoglycerate mutase
18. The crystal structure of the bifunctional enzyme 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase reveals distinct domain homologies
19. Investigation of two yeast genes encoding putative isoenzymes of phosphoglycerate mutase
20. Purification and characterization of acid phosphatase in rat liver lysosomal contents
21. Structure, function, and evolution of phosphoglycerate mutases: Comparison with fructose-2,6-bisphosphatase, acid phosphatase, and alkaline phosphatase
22. Comparison of the binuclear metalloenzymes diphosphoglycerate-independent phosphoglycerate mutase and alkaline phosphatase: Their mechanism of catalysis via a phosphoserine intermediate
23. GenTHREADER: An efficient and reliable protein fold recognition method for genomic sequences
24. Improved methods for building protein models in electron density maps and the location of errors in these models
25. Hidden Markov models for detecting remote protein homologies
26. Enhanced genome annotation using structural profiles in the program 3D-PSSM
27. Use of non-crystallographic symmetry in protein structure refinement
28. Phi/Psi-chology: Ramachandran revisited
29. Crystal structure of phytase from Aspergillus ficuum at 2.5 A resolution
30. Crystal structure of Aspergillus niger pH 2.5 acid phosphatase at 2.4 Å resolution
31. MOLSCRIPT: A program to produce both detailed and schematic plots of protein structures
32. The complete genome sequence of the gram-positive bacterium Bacillus subtilis
33. Structural origins of L(+)-tartrate inhibition of human prostatic acid phosphatase
34. Cleavage of structural proteins during the assembly of the head of bacteriophage T4
35. PROCHECK: A program to check stereochemical quality of protein structures
36. Cloning and nucleotide sequence of the genes encoding triose phosphate isomerase, phosphoglycerate mutase and enolase from Bacillus subtilis
37. Glu327 is part of the catalytic triad in rat liver fructose-2,6-bisphosphalase
38. Alkaline phosphatase (crystalline)
39. Reaction mechanism of fructose-2,-6-bisphosphatase. A mutation of nucleophilic catalyst, histidine 256-induces an alteration in the reaction pathway
40. SCOP: A structural classification of proteins database for the investigation of sequences and structures
41. Heterologous expression of human prostatic acid phosphatase and site-directed mutagenesis of the enzyme active site
42. How to measure and predict the molar absorption coefficient of a protein
43. Analysis of the function of a putative 2,3-diphosphoglyceric acid-dependent phosphoglycerate mutase from Bacillus subtilis
44. Improved tools for biological sequence comparison
45. Active site sequence of hepatic fructose-2,6-bisphosphatase. Homology in primary structure with phosphoglycerate mutase
46. A structural model for the rolA protein and its interaction with DNA
47. Sulphate ions observed in the 2.12Å structure of a new crystal form of Saccharomyces cerevisiae phosphoglycerate mutase provide insights into understanding the catalytic mechanism
48. Structural modeling of a plant disease resistance gene product domain
49. Comparative protein modeling by satisfaction of spatial restraints
50. MODELLER: A program for protein structure prediction
51. Large-scale protein structure modeling of the Saccharomyces cerevisiae genome
52. Three-dimensional structure of rat acid phosphatase
53. Recognition of errors in three-dimensional structures of proteins
54. Complete genome sequence of the alkaliphilic bacterium Bacillus halodurans and genomic sequence comparison with Bacillus subtilis
55. Human prostatic acid phosphatase: A histidine phosphatase
56. Substrate specificity and pH dependence of homogeneous wheat germ acid phosphatase
57. Structure and heterologous expression of a gene encoding fructose-6-phosphate,2-kinase/fructose-2,6-bisphosphatase from Arabidopsis thaliana
58. Substitution of His-181 by alanine in yeast phosphoglycerate mutase leads to cofactor-induced dissociation of the tetrameric structure
59. Crystal structure of the H256A mutant of rat testis fructose-6-phosphate,2-kinase/fructose-2,6-bisphosphatase. Fructose 6-phosphate in the active site leads to mechanisms for both mutant and wild type bisphosphatase activities