Biological significance of a universally conserved transcription mediator in metazoan developmental signaling pathways

Development

Volumn 128, Issue 16, 2001, Pages 3095-3104

  Kwon, J Y ^a   Lee, J ^a  

^a Yonsei University   (South Korea)

Author keywords

C. elegans; med 6; Ras; rde 1; RNAi; Transcriptional mediator; Wnt

Indexed keywords

GROWTH FACTOR; PROTEIN MED 6; RAS PROTEIN; REGULATOR PROTEIN; RNA; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG; WNT PROTEIN;

ALLELE; ARTICLE; CAENORHABDITIS ELEGANS; CONTROLLED STUDY; DEVELOPMENTAL BIOLOGY; GENE ACTIVITY; GENE MAPPING; GENE MUTATION; GENE SEQUENCE; GENETIC ANALYSIS; GENETIC CONSERVATION; GENETIC TRANSCRIPTION; IN VIVO CULTURE; MALE; MEDIATOR; METAZOON; MOLECULAR EVOLUTION; MOLECULAR GENETICS; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN ANALYSIS; SEQUENCE ANALYSIS; SEQUENCE HOMOLOGY; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION; YEAST;

ALLELES; AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; CAENORHABDITIS ELEGANS; CAENORHABDITIS ELEGANS PROTEINS; CONSERVED SEQUENCE; FEMALE; FUNGAL PROTEINS; GENETIC MARKERS; HELMINTH PROTEINS; HOMOZYGOTE; MALE; MOLECULAR SEQUENCE DATA; MUTATION; PHENOTYPE; PHYSICAL CHROMOSOME MAPPING; RAS PROTEINS; RNA, BACTERIAL; SACCHAROMYCES CEREVISIAE PROTEINS; SIGNAL TRANSDUCTION; TRANS-ACTIVATORS; TRANSCRIPTION, GENETIC;

EID: 0034846321     PISSN: 09501991     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (35)

1. The let-23 gene necessary for Caenorhabditis elegans vulval induction encodes a tyrosine kinase of the EGF receptor subfamily
2. Mammalian Srb/Mediator complex is targeted by adenovirus E1A protein
3. The genetics of Caenorhabditis elegans
4. Genome sequence of the nematode C. elegans: A platform for investigating biology
5. Posterior pattern formation in C. elegans involves position-specific expression of a gene containing a homeobox
6. Transgene-mediated cosuppression in the C. elegans germ line
7. Patterning of Caenorhabditis elegans posterior structures by the Abdominal-B homolog. eg1-5
8. A novel human SRB/MED-containing cofactor complex, SMCC, involved in transcription regulation
9. let-60, a gene that specifies cell fates during C. elegans vulval induction, encodes a ras protein
10. The gene lin-3 encodes an inductive signal for vulval development in C. elegans
11. Dissecting the regulatory circuitry of a eukaryotic genome
12. Hox gene expression in a single Caenorhabditis elegans cell is regulated by a caudal homolog and intercellular signals that inhibit wnt signaling
13. Mammalian mediator of transcriptional regulation and its possible role as an end-point of signal transduction pathways
14. Genetic analysis of a major segment [LGV(left)] of the genome of Caenorhabditis elegans
15. Different levels of the C. elegans growth factor LIN-3 promote distinct vulval precursor fates
16. Distinct requirements for the somatic and germline expression of a generally expressed Caenorhabditis elegans gene
17. A multiprotein mediator of transcriptional activation and its interaction with the C-terminal repeat domain of RNA polymerase II
18. An RNA polymerase II holoenzyme responsive to activators
19. Caenorhabditis elegans mediator complexes are required for developmental-specific transcriptional activation
20. Requirement for a functional interaction between mediator components Med6 and Srb4 in RNA polymerase II transcription
21. A transcriptional mediator protein that is required for activation of many RNA polymerase II promoters and is conserved from yeast to humans
22. Transcriptional regulation through Mediator-like coactivators in yeast and metazoan cells
23. Mediator protein mutations that selectively abolish activated transcription
24. The genetic analysis of a reciprocal translocation, eT1 (III; V), in Caenorhabditis elegans
25. Genomic organization in Caenorhabditis elegans: Deficiency mapping on linkage group V(left)
26. sur-2, a novel gene, functions late in the let-60 ras-mediated signaling pathway during Caenorhabditis elegans vulval induction
27. NURD-complex genes antagonise Ras-induced vulval development in Caenorhabditis elegans
28. Pattern formation during vulval development in C. elegans
29. The combined action of two intercellular signaling pathways specifies three cell fates during vulval induction in C. elegans
30. NAT, a human complex containing Srb polypeptides that functions as a negative regulator of activated transcription
31. The rde-1 gene, RNA interference, and transposon silencing in C. elegans
32. A multisubunit complex associated with the RNA polymerase II CTD and TATA-binding protein in yeast
33. Regulation of cellular responsiveness to inductive signals in the developing C. elegans nervous system
34. The role of lin-22, a hairy/enhancer of split homolog, in patterning the peripheral nervous system of C. elegans
35. A C. elegans mediator protein confers regulatory selectivity on lineage-specific expression of a transcription factor gene