Optically active antifungal azoles. XIII. Synthesis of stereoisomers and metabolites of 1-[(1Rr,2R)-2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3(1H-1,2,4-triazol-1- yl)propyl]-3-[4-(1H-1-tetrazolyl)phenyl]-2-imidazolidinone (TAK-456)

Chemical and Pharmaceutical Bulletin

Volumn 49, Issue 9, 2001, Pages 1110-1119

  Ichikawa, T ^a   Yamada, M ^a   Yamaguchi, M ^a   Kitazaki, T ^a   Matsushita, Y ^a   Higashikawa, K ^a   Itoh, K ^a  

^a TAKEDA PHARMACEUTICAL COMPANY LIMITED   (Japan)

Author keywords

Antifungal activity; Metabolite; Optically active antifungal triazole; Stereocontrolled synthesis; Stereoisomer; TAK 456

Indexed keywords

1 [2 (2,4 DIFLUOROPHENYL) 2 HYDROXY 1 METHYL 3 (1H 1,2,4 TRIAZOL 1 YL)PROLYL] 4 HYDROXY 3 [4 (1H 1 TETRAZOLYL)PHENYL] 2 IMIDAZOLIDINONE; 1 [2 (2,4 DIFLUOROPHENYL) 2 HYDROXY 1 METHYL 3 (1H 1,2,4 TRIAZOL 1 YL)PROPYL] 3 [4 (1H 1 TETRAZOLYL)PHENYL] 2 IMIDAZOLIDINONE; 1 [2 (2,4 DIFLUOROPHENYL) 2 HYDROXY 1 METHYL 3 (1H 1,2,4 TRIAZOL 1 YL)PROPYL] 3 [4 (1H TETRAZOL 1 YL)PHENYL] 2 IMIDAZOLIDINONE; 1 [2 (2,4 DIFLUOROPHENYL) 2 HYDROXY 1 METHYL 3 (1H 1,2,4 TRIAZOL 1 YL)PROPYL] 5 HYDROXY 3 [4 (1H 1 TETRAZOLYL)PHENYL] 2 IMIDAZOLIDINONE; ANTIFUNGAL AGENT; DRUG METABOLITE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIFUNGAL ACTIVITY; ARTICLE; DIASTEREOISOMER; DRUG METABOLISM; DRUG SYNTHESIS; ENANTIOMER; LIVER HOMOGENATE; MALE; NONHUMAN; RAT; STEREOISOMERISM;

ANIMALS; ANTIFUNGAL AGENTS; BIOTRANSFORMATION; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CRYSTALLOGRAPHY, X-RAY; IMIDAZOLES; LIVER; MAGNETIC RESONANCE SPECTROSCOPY; MASS SPECTROMETRY; MODELS, MOLECULAR; RATS; RATS, SPRAGUE-DAWLEY; STEREOISOMERISM; TETRAZOLES;

EID: 0034843991     PISSN: 00092363     EISSN: None     Source Type: Journal    
DOI: 10.1248/cpb.49.1110     Document Type: Article

References (25)