An examination of polymorphic genes and folate metabolism in mothers affected by a spina bifida pregnancy

Molecular Genetics and Metabolism

Volumn 73, Issue 4, 2001, Pages 322-332

  Lucock, Mark ^a   Daskalakis, Ioannis ^a   Hinkins, Matthew ^a   Yates, Zoe ^a  

^a UNIVERSITY OF LEEDS   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2); FOLIC ACID; METHIONINE SYNTHASE;

ADULT; ALLELE; ARTICLE; CASE REPORT; CONTROLLED STUDY; FEMALE; FOLATE METABOLISM; GENE MUTATION; GENETIC POLYMORPHISM; GENOTYPE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; NEURAL TUBE DEFECT; PHENOTYPE; PREGNANCY; PRIORITY JOURNAL; RADIOASSAY; SINGLE NUCLEOTIDE POLYMORPHISM; SPINA BIFIDA;

EID: 0034842062     PISSN: 10967192     EISSN: None     Source Type: Journal    
DOI: 10.1006/mgme.2001.3205     Document Type: Article

References (30)

1. Prevention of neural tube defects: Results of the Medical Research Council Vitamin Study
2. Prevention of the first occurrence of neural tube defects by periconceptional vitamin supplementation
3. Double-blind randomised controlled trial of folate treatment before conception to prevent recurrence of neural-tube defects
4. Further experience of vitamin supplementation for prevention of neural tube defect recurrences
5. A randomised trial of low dose folic acid to prevent neural tube defects
6. Maternal plasma folate and vitamin B 12 are independent risk factors for neural tube defects
7. 12) in amniotic fluid
8. Folic acid: Nutritional biochemistry, molecular biology, and role in disease processes
9. A genetic defect in 5,10-methylenetetrahydrofolate reductase in neural tube defects
10. Mutated methylenetetrahydrofolate reductase as a risk factor for spina bifida
11. Impaired regeneration of monoglutamyl tetrahydrofolate leads to cellular folate depletion in mothers affected by a spina bifida pregnancy
12. 5,10-Methylenetetrahydrofolate reductase C677T genotypes and folate related risk factors for neural tube defects
13. Altered folate metabolism and disposition in mothers affected by a spina bifida pregnancy: Influence of 677c→t methylenetetrahydrofolate reductase and 2756a→g methionine synthase genotypes
14. Spina bifida, 677ct mutation, and role of folate
15. Methylenetetrahydrofolate reductase and neural tube defects
16. Homocysteine and neural tube defects
17. Sequence analysis of the coding region of human methionine synthase: Relevance to hyperhomocysteinaemia in NTD and vascular disease
18. Methionine synthase and neural tube defects
19. Methionine synthase D 919G polymorphism is a significant but modest determinant of circulating homocysteine concentrations
20. A second common mutation in the methylenetetrahydrofolate reductase gene: An additional risk factor for neural tube defects?
21. A common variant in methionine synthase reductase combined with low cobalamin (vitamin B12) increases risk for spina bifida
22. A candidate genetic risk factor for vascular disease: A common mutation in methylenetetrahydrofolate reductase
23. Determination of plasma total homocysteine and cysteine using HPLC with fluorescence detection and an ammonium 7-fluoro-2,1,3-benzoxadiazole-4-sulphonate (SBDF-) derivitization protocol optimised for antioxidant concentration, derivitization reagent concentration, temperature, and matrix pH
24. Folylpolyglutamate synthesis and role in the regulation of one-carbon metabolism
25. Common mutation in the methylenetetrahydrofolate reductase gene is associated with, an accumulation of formylated tetrahydrofolates in red blood cells
26. Folate-homocysteine interrelations: Potential new markers of folate status
27. NAD-dependent methylenetetrahydrofolate dehydrogenase is expressed by immortal cells
28. Molecular genetic analysis of the gene encoding the trifunctional enzyme MTHFD (methylenetetrahydrofolate-deydrogenase, methenyltetrahydrofolate-cyclohydrolase, formyltetrahydrofolate-synthetase) in patients with neural tube defects
29. The metabolic role of leucovorin
30. Substrate flux through methylenetetrahydrofolate dehydrogenase: Predicted effects of the concentration of methylenetetrahydrofolate on its partitioning into pathways leading to nucleotide biosynthesis or methionine regeneration