Efficient downregulation of major histocompatibility complex class I molecules in human epithelial cells infected with cytomegalovirus

Journal of General Virology

Volumn 82, Issue 9, 2001, Pages 2061-2070

  Benz, C ^a   Reusch, U ^a   Muranyi, W ^a   Brune, W ^a   Atalay, R ^a   Hengel, H ^a  

^a ROBERT KOCH INSTITUTE   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CD8 ANTIGEN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; STRUCTURAL PROTEIN; VIRUS GLYCOPROTEIN; VIRUS PROTEIN;

ANTIGEN EXPRESSION; ARTICLE; CELL CULTURE; CELL DIFFERENTIATION; CELL LINE; CONTROLLED STUDY; CYTOLYSIS; CYTOMEGALOVIRUS INFECTION; CYTOTOXIC T LYMPHOCYTE; DISEASE SEVERITY; DOWN REGULATION; EPITHELIUM CELL; FIBROBLAST; GENE EXPRESSION; HEPATOBILIARY SYSTEM; HUMAN; HUMAN CELL; HUMAN CYTOMEGALOVIRUS; IMMEDIATE EARLY GENE; IMMUNE DEFICIENCY; INTESTINE EPITHELIUM CELL; KINETICS; LIVER; LIVER CELL; ORGAN; PRIORITY JOURNAL; PROGENY; PROTEIN SYNTHESIS; TARGET CELL; VIRUS REPLICATION; VIRUS TITRATION;

EID: 0034840034     PISSN: 00221317     EISSN: None     Source Type: Journal    
DOI: 10.1099/0022-1317-82-9-2061     Document Type: Article

References (58)

1. Controlled synthesis of HBsAg in a differentiated human liver carcinoma-derived cell line
2. Human cytomegalovirus inhibits antigen presentation by a sequential multistep process
3. The ER-luminal domain of the HCMV glycoprotein US6 inhibits peptide translocation by TAP
4. A rapid microneutralization assay for the measurement of neutralizing antibody reactive with human cytomegalovirus
5. Effect of cytomegalovirus infection on expression of HLA-antigens in liver allografts
6. Cytomegalovirus infection persists in the liver graft in the vanishing bile duct syndrome
7. β-microglobulin-independent MHC class Ib molecule expressed by human intestinal epithelium
8. Clinical use of immunohistopathologic methods for the diagnosis of cytomegalovirus hepatitis in human liver allograft biopsy specimens
9. Human cytomegalovirus down-regulates HLA class I expression by reducing the stability of class I H chains
10. Cytomegalovirus
11. Cytomegalovirus infection
12. Cytomegalovirus prevents antigen presentation by blocking the transport of peptide-loaded major histocompatibility complex class I molecules into the medial-Golgi compartment
13. Human cytomegalovirus infects Caco-2 intestinal epithelial cells basolaterally regardless of the differentiation state
14. Soluble interleukin-6 receptor strongly increases the production of acute-phase protein by hepatoma cells but exerts minimal changes on human primary hepatocytes
15. Cell stress-regulated human major histocompatibility complex class I gene expressed in gastrointestinal epithelium
16. Human trophoblast cells are permissive to the complete replicative cycle of human cytomegalovirus
17. Permissive cytomegalovirus infection of primary villous term and first trimester trophoblasts
18. Restoration of cytomegalovirus antigen presentation by gamma interferon combats viral escape
19. Cytokines restore MHC class I complex formation and control antigen presentation in human cytomegalovirus-infected cells
20. Human cytomegalovirus inhibits peptide translocation into the endoplasmic reticulum for MHC class I assembly
21. A viral ER-resident glycoprotein inactivates the MHC-encoded peptide transporter
22. Macrophages escape inhibition of major histocompatibility complex class I-dependent antigen presentation by cytomegalovirus
23. Increased expression of adhesion molecules (CD54, CD29 and CD44) on fibroblasts infected with cytomegalovirus
24. Human cytomegalovirus infection of Caco-2 cells occurs at the basolateral membrane and is differentiation state dependent
25. Fine mapping of transcripts expressed from the US6 gene family of human cytomegalovirus strain AD169
26. Multiple independent loci within the human cytomegalovirus unique short region down-regulate expression of major histocompatibility complex class I heavy chains
27. Human cytomegalovirus US3 impairs transport and maturation of major histocompatibility complex class I heavy chains
28. Latent infection and the elusive cytomegalovirus
29. Biliary adenocarcinoma. Characterisation of three new human tumor cell lines
30. The immunoevasive function encoded by the mouse cytomegalovirus gene m152 protects the virus against T cell control in vivo
31. Fine-needle aspiration biopsy in the monitoring of liver allografts. Different cellular findings during rejection and cytomegalovirus infection
32. Persistent cytomegalovirus in liver allografts with chronic rejection
33. The human cytomegalovirus US6 glycoprotein inhibits transporter associated with antigen processing-dependent peptide translocation
34. Human cytomegalovirus inhibits major histocompatibility complex class II expression by disruption of the Jak/Stat pathway
35. Growth of human hepatoma cell lines with differentiated functions in chemically defined medium
36. Construction of a novel bovine papillomavirus vector without detectable transforming activity suitable for gene transfer
37. Use of monoclonal antibody (W6/32) in structural studies of HLA-A, B, C antigens
38. Cytomegalovirus hepatitis in liver transplantation: Prospective analysis of 93 consecutive orthotopic liver transplantations
39. Early diagnosis of cytomegalovirus hepatitis in liver transplant recipients: Role of immunostaining, DNA hybridization and culture of hepatic tissue
40. Analysis of proteins encoded by IE regions 1 and 2 of human cytomegalovirus using monoclonal antibodies generated against recombinant antigens
41. Reconstitution of CD8 T cells is essential for the prevention of multiple-organ cytomegalovirus histopathology after bone marrow transplantation
42. Localization of human cytomegalovirus structural proteins to the nuclear matrix of infected human fibroblasts
43. Expression of human leukocyte antigens class I and class II on cultured biliary epithelial cells after cytomegalovirus infection
44. Cytotoxic T-cell immunity to virus-infected non-haematopoietic cells requires presentation of exogenous antigen
45. Fibroblasts, epithelial cells, endothelial cells and smooth muscle cells are major targets of human cytomegalovirus infection in lung and gastrointestinal tissues
46. Hepatocytes are permissive for human cytomegalovirus infection in human liver cell culture and in vivo
47. Liver disease in cytomegalovirus mononucleosis: A light microscopical and immunoperoxidase study of six cases
48. Human cytomegalovirus strain Towne glycoprotein B is processed by proteolytic cleavage
49. Analysis of sequential changes in major histocompatibility complex expression in human liver grafts after transplantation
50. Clinical patterns of cytomegalovirus disease after liver transplantation
51. Cytomegalovirus hepatitis in normal and immune compromised hosts
52. Localization of cytomegalovirus antigens in liver allografts over time
53. Preparation of tissue for DNA flow cytometric analysis
54. Role of apical and basolateral membranes in replication of human cytomegalovirus in polarized retinal pigment epithelial cells
55. Human cytomegalovirus-infected cells have unstable assembly of major histocompatibility complex class I complexes and are resistant to lysis by cytotoxic T lymphocytes
56. The human cytomegalovirus US11 gene product dislocates MHC class I heavy chains from the endoplasmic reticulum to the cytosol
57. Sec61-mediated transfer of a membrane protein from the endoplasmic reticulum to the proteasome for destruction
58. Down-regulation of the surface expression of class I MHC antigens by human cytomegalovirus