Unexplained sporadic and recurrent miscarrage in the new millennium: A critical analysis of immune mechanisms and treatments

Human Reproduction Update

Volumn 7, Issue 5, 2001, Pages 501-511

  Clark, David A ^a   Coulam, Carolyn B ^b   Daya, Salim ^a   Chaouat, Gerard ^c  

^a MCMASTER UNIVERSITY   (Canada)

^b Rinehart Center for Reproductive Medicine   (United States)

^c HÔPITAL ANTOINE BÉCLÈRE   (France)

Author keywords

Cytokines; Immunotherapy; IVIg; Meta analysis; Miscarriage

Indexed keywords

ANTITHROMBIN III; BLOOD CLOTTING FACTOR 10A; CHORIONIC GONADOTROPIN BETA SUBUNIT; COMPLEMENT COMPONENT C3; CYTOKINE; CYTOLYSIN; GAMMA INTERFERON; GRANULOCYTE ANTIBODY; HEPARIN; HIRUDIN; HISTOCOMPATIBILITY ANTIGEN; IMMUNOGLOBULIN G; INTERLEUKIN 8; MACROPHAGE INFLAMMATORY PROTEIN 2; MONOCLONAL ANTIBODY; NEUTRALIZING ANTIBODY; NITRIC OXIDE; PERFORIN; PHOSPHOLIPID ANTIBODY; PROCOAGULANT; PROTHROMBIN; T LYMPHOCYTE ANTIGEN; T LYMPHOCYTE RECEPTOR ALPHA CHAIN; T LYMPHOCYTE RECEPTOR BETA CHAIN; T LYMPHOCYTE RECEPTOR DELTA CHAIN; T LYMPHOCYTE RECEPTOR GAMMA CHAIN; THROMBIN; TRYPTOPHANASE; TUMOR NECROSIS FACTOR ALPHA; UNINDEXED DRUG;

ADULT; ALLOTRANSPLANTATION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; CELL HETEROGENEITY; CHILDBIRTH; CLINICAL RESEARCH; CONTROLLED STUDY; DATA ANALYSIS; DRUG MECHANISM; EMBRYO; EMPIRICISM; FEMALE; FETUS; HEALTH CARE QUALITY; HUMAN; HUMAN CELL; IMMUNE RESPONSE; IMMUNOPATHOGENESIS; IMMUNOTHERAPY; LEUKOCYTE TRANSFUSION; MAJOR CLINICAL STUDY; MALE; META ANALYSIS; MOUSE; NEWBORN; NONHUMAN; PATHOPHYSIOLOGY; PATIENT SELECTION; PEER REVIEW; PILOT STUDY; PRIORITY JOURNAL; PUBLICATION; RECURRENT ABORTION; REVIEW; SPONTANEOUS ABORTION; TREATMENT INDICATION; TREATMENT PLANNING;

ABORTION, HABITUAL; ABORTION, SPONTANEOUS; FEMALE; HUMANS; IMMUNE SYSTEM; IMMUNOGLOBULINS, INTRAVENOUS; IMMUNOTHERAPY; LEUKOCYTES;

EID: 0034839487     PISSN: 13554786     EISSN: None     Source Type: Journal    
DOI: 10.1093/humupd/7.5.501     Document Type: Review

References (101)

1. Preconceptual natural killer cell activation as a predictor of miscarriage
2. Murine T cell determination of pregnancy outcome: I. Effects of strain, αβ T cell receptor, γδ T cell receptor, and γδ T cell subsets
3. TNF-αP55 receptor knockout mice demonstrate two distinct types of endotoxin-induced rejection of the embryo qua parasite
4. From the decidua cell internet: Trophoblast-recognizing T cells
5. + T cells influence success or failure of pregnancy in CBAXDBA/2 matings
6. Effect of filtration of platelet concentrates on the accumulation of cytokines and platelet release factors during storage
7. The effects of blood transfusion on cytokine production by Th1 and Th2 lymphocytes in the mouse
8. Immunological prevention of spontaneous early embryo resorption is mediated by non-specific immunostimulation
9. Thrombophilia-associated pregnancy wastage
10. Biologic effects of leukocytes present in transfused cellular blood products
11. Retrospective and prospective epidemiological studies of 1,500 karyotyped spontaneous human abortions
12. Embryo loss, blastomere development and chromosome constitution after human chorionic gonadotropin-induced ovulation in mice and rats with regular cycles
13. Treatment of recurrent aborters by immunization with paternal cells l a controlled trial
14. Genetic aspects of the CBAXDBA/2 and B10XB10. A models of murine pregnancy failure and its prevention by lymphocyte immunisation
15. Lymphocyte immunotherapy (LI) increases serum levels of progesterone induced blocking factor (PIBF)
16. Intravenous immunoglobulin treatment of women with multiple miscarriages
17. Animal models of recurrent pregnancy loss
18. Controversies in reproductive immunology
19. Hard science versus phenomenology in reproductive immunology
20. Other immunomodulatory effects of blood transfusion
21. T cells in pregnancy: Illusion or reality?
22. Is there an immunological cause of repeated pregnancy wastage?
23. Th1/Th2 imbalance due to cytokine-producing NK, γδT, and NK-γδT cells in murine pregnancy decidua in success or failure of pregnancy
24. Trials and tribulations in the treatment of recurrent spontaneous abortion
25. Implications of abnormal trophoblast karyotype for the evidence-based approach to the understanding, investigation, and treatment of recurrent - Spontaneous abortion
26. The use of allogeneic leukocytes or IV IgG for the treatment of patients with recurrent spontaneous abortions
27. The cutting edge: Cytokine-dependent abortion in CBAXDBA/2 mice is mediated by the procoagulant fg12 prothrombinase
28. Why did your mother reject you? Immunogenetic determinants of the response to environmental selective pressure expressed at the uterine level
29. Fg12 in pregnancy: A novel prothrombinase at the fetomaternal interface may prevent bleeding and cause abortions
30. Fg12 prothrombinase expression in mouse trophoblasts and decidua triggers abortion but may be countered by OX-2
31. Labile CD200 tolerance signal important in transfusion-related immunomodulation (TRIM) prevention of recurrent miscarriages
32. Report from the Ethics Committee for Immunotherapy, American Society for Immunology of Reproduction
33. Reproductive performance in women with repeated pregnancy losses and multiple partners
34. Ultrasonographic findings of pregnancy losses after treatment for recurrent pregnancy loss: Intravenous immunoglobulin versus placebo
35. Intravenous immunoglobulin for treatment of recurrent pregnancy loss
36. Immunotherapy for recurrent pregnancy loss: Analysis of results of clinical trials
37. Hemostatic and metabolic abnormalities in women with unexplained recurrent abortion
38. The Edinburgh mouse atlas
39. Endometriosis and spontaneous abortion
40. Habitual abortion
41. The effectiveness of allogeneic leukocyte immunization in unexplained primary recurrent spontaneous abortion
42. Critical analysis of intravenous immunoglobulin therapy for recurrent miscarriage
43. Menstrual cycle dependent fluctuations in NK and T lymphocytes from non-pregnant human endometrium
44. Controlled, trial on intravenous immunoglobulin for prevention of recurrent spontaneous abortion
45. A cytogenetic study of 1000 spontaneous abortions
46. γδ cells: A right time and a right place for a conserved third way of protection
47. A randomized controlled trial comparing plasma removal with white cell reduction to prevent reactions to platelets
48. Recognition of trophoblasts by γδ T cells
49. Suppression of natural killer cell activity by monocytes following immunotherapy for recurrent spontaneous aborters
50. T helper 1-type cellular immunity to trophoblast in women with recurrent abortions
51. Transfusion of red cells is associated with increased incidence of bacterial infection after colorectal surgery: A prospective study
52. Immunotherapy and recurrent abortion: A randomized clinical trial
53. Involvement of decidual Vγ14 NKT cells in abortion
54. Randomized comparison of leukocyte-depleted versus buffy-coat poor blood transfusions and complications after colorectal surgery
55. Recurrent miscarriage (REMIS) study: How should data from women who do not become pregnant be handled?
56. Clinical trial of immunomodulation with a biological response modifier in unexplained recurrent abortion patients
57. Uterine NK cells and trophoblast class I molecules
58. Blood transfusions and total joint replacement surgery: T helper 2 (TH2) cytokine secretion and clinical outcome
59. Activation of a novel prothrombinase, fg12, as a basis for the pregnancy complications spontaneous abortion and pre-eclampsia
60. Elevated peripheral blood natural killer cells are effectively downregulated by immunoglobulin G infusion in women with recurrent spontaneous abortions
61. Prednisone and aspirin in women with autoantibodies and unexplained recurrent fetal loss
62. Endometrial T, B, and NK cells in patients with recurrent abortion: Altered profile and pregnancy outcome
63. Macrophages and migratory cells in endometrium relevant to implantation
64. The role of T-helper cytokines in human reproduction
65. Early pregnancy wastage: Relationship between chorionic vascularization and embryonic development
66. Evidence of spontaneous abortion among normal women and insulin-dependent women whose pregnancies were identified within 21 days of conception
67. Gamma delta T cells of human early pregnancy decidua: Evidence for local proliferation, phenotypic heterogeneity, and extrathymic differentiation
68. Cytogenetic findings in echocardiographically defined blighted ovum abortions
69. Immunology of early pregnancy
70. Effect of paternal lymphocyte immunisation on birthweight and pregnancy outcome
71. Controlled trial of recurrent spontaneous abortion by immunisation with paternal cells
72. Prevention of allogeneic fetal rejection by tryptophan catabolism
73. A comparative study of the in vitro immunomodulatory activity of human intact immunoglobulin (7S IVIG), F(ab')2 fragments (5S IVIG) and Fc fragments. Evidence for post-transcriptional IL-2 modulation
74. Sequential analysis of spontaneous abortion. II. Collaborative study data show that gravidity determines a very substantial rise in risk
75. Mononuclear-cell immunisation in prevention of recurrent miscarriages: A randomised trial
76. Defective production of both leukemia inhibitory factor and type 2 T-helper cytokines by decidual T cells in unexplained recurrent abortions
77. The role of γ/δT cell receptor positive cells in pregnancy
78. Proceedings of Concensus Conference on Worldwide Collaborative Observational Study on Immunotherapy for Recurrent Spontaneous Abortion
79. Worldwide prospective observational study and meta-analysis on allogeneic leukocyte immunotherapy for recurrent spontaneous abortion
80. Habitual abortion in 678 healthy patients: Investigation and prevention
81. Intravenous immunoglobulin inhibits natural killer cell activity in vivo in women with recurrent spontaneous abortion
82. Why randomized controlled trials fail but needn't: A new series is launched
83. Placental and decidual histology in spontaneous abortion: Detailed description and correlations with chromosome number
84. Increased incidence of spontaneous abortion and infertility in women with scleroderma before disease onset: A controlled study
85. Postmortem chorionic villus sampling: Correlation of cytogenetic and ultrasound findings
86. The impact of the factor V Leiden mutation on pregnancy
87. Pregnancy and perforin: What could be the role of a 'natural killer' in the decidua?
88. Prevention of unexplained recurrent spontaneous abortion using intravenous immunoglobulin: A prospective, randomized, double-blinded, placebo-controlled trial
89. Meta-analysis of the literature or of individual patient data: Is there a difference?
90. Etiologic factors and subsequent reproductive performance in 195 couples with a prior history of habitual abortion
91. The role of γ/δ T cells in progesterone-mediated immunomodulation during pregnancy: A review
92. Natural killer cell activity and cytokine production after in vitro immunoglobulin treatment of lymphocytes derived from pregnant women with or without risk for spontaneous abortion
93. Immunotherapy in recurrent spontaneous abortion: Who, how, outcome
94. Rationale, objectives, and interpretation of the findings of clinical studies of the immunomodulatory effects of blood transfusions
95. Deleterious effects of transfusion-associated immunomodulation: Appraisal of the evidence and recommendations for prevention
96. Spontaneous abortion risks in man: Data from reproductive histories collected in a medical genetics unit
97. A critical role for murine complement regulator Crry in fetomaternal tolerance
98. Effects of common environmental exposures on spontaneous abortion of defined karyotypes
99. Decidual natural killer cells in recurrent spontaneous abortion with normal chromosome content
100. Activated protein C resistance and factor V Leiden mutation can be associated with first- as well as second-trimester recurrent pregnancy loss