Combination of a free radical scavenger and heparin reduces cerebral hemorrhage after heparin treatment in a rabbit middle cerebral artery occlusion model

Stroke

Volumn 32, Issue 9, 2001, Pages 2157-2163

  Zhao, Bing Qiao ^a   Suzuki, Yasuhiro ^a   Kondo, Kazunao ^a   Ikeda, Yasuhiko ^a   Umemura, Kazuo ^a  

^a HAMAMATSU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Cerebral ischemia; Free radicals; Heparin; Intracerebral hemorrhage; Middle cerebral artery occlusion; Rabbits

Indexed keywords

ASCORBIC ACID 2 [3,4 DIHYDRO 2,5,7,8 TETRAMETHYL 2 (4,8,12 TRIMETHYLTRIDECYL) 2H 1 BENZOPYRAN 6 YL HYDROGEN PHOSPHATE] POTASSIUM; HEPARIN; PLACEBO; SCAVENGER; THROMBOPLASTIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BOLUS INJECTION; BRAIN HEMORRHAGE; BRAIN ISCHEMIA; COMBINATION CHEMOTHERAPY; CONTROLLED STUDY; DISEASE EXACERBATION; DISEASE SEVERITY; DRUG EFFICACY; HEPARINIZATION; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; NEUROLOGICAL COMPLICATION; NEUROPROTECTION; NONHUMAN; PARTIAL THROMBOPLASTIN TIME; PHOTOTOXICITY; PRIORITY JOURNAL; RABBIT; STROKE; THROMBOGENESIS;

EID: 0034831372     PISSN: 00392499     EISSN: None     Source Type: Journal    
DOI: 10.1161/hs0901.095640     Document Type: Article

References (34)

1. Antithrombotic treatments in acute ischemic stroke
2. Frequency of major complications of aspirin, warfarin, and intravenous heparin for secondary stroke prevention
3. Matrix metalloproteinases increase very early during experimental focal cerebral ischemia
4. Early appearance of activated matrix metalloproteinase-9 after focal cerebral ischemia in mice: A possible role in blood-brain barrier dysfunction
5. Metalloproteinase inhibition blocks edema in intracerebral hemorrhage in the rat
6. Overexpression of copper and zinc superoxide dismutase in transgenic mice prevents the induction and activation of matrix metalloproteinases after cold injury-induced brain trauma
7. Metalloproteinase inhibition reduces thrombolytic (tissue plasminogen activator)-induced hemorrhage after thromboembolic stroke
8. Pharmacological effects of the spin trap agents N-t-butyl-phenylnitrone (PBN) and 2,2,6,6-tetramethylpiperidine-N-oxyl (TEMPO) in a rabbit thromboembolic stroke model: Combination studies with the thrombolytic tissue plasminogen activator
9. Cerebral hemorrhage due to heparin limits its neuroprotective effects: Studies in a rabbit model of photothrombotic middle cerebral artery occlusion
10. ME3277, a GPIIb/IIIa antagonist, reduces cerebral infarction without enhancing intracranial hemorrhage in photothrombotic occlusion of rabbit middle cerebral artery
11. Increased cerebral infarction by cyclic flow reductions: Studies in the guinea pig MCA thrombosis model
12. Hemorrhagic complications of thrombolytic therapy in experimental stroke
13. Antioxidant properties of EPC-K1: A study on mechanisms
14. 2 receptor antagonist, vapiprost, in a rat middle cerebral artery thrombosis model
15. Argon laser-induced arterial photothrombosis: Characterization and possible application to therapy of arteriovenous malformations
16. Failure of MK-801 to reduce infarct volume in thrombotic middle cerebral artery occlusion in rats
17. Vessel wall injury and arterial thrombosis induced by a photochemical reaction
18. Induction of reproducible brain infarction by photochemically initiated thrombosis
19. Effect of 21-aminosteroid lipid peroxidation inhibitor, U74006F, in the rat middle cerebral artery occlusion model
20. Intracranial blood flow velocities in acute ischemic stroke
21. Pharmacokinetics of rose bengal in the rat, rabbit, dog and guinea pig
22. Anticoagulant, thrombolytic, and antiplatelet drugs
23. Fatal ischemic brain edema after unsuccessful thrombolysis
24. Studies on the profibrinolytic actions of heparin and its fractions
25. Effect of plasminogen activator (urokinase), plasmin, and thrombin on glycoprotein and collagenous components of basement membrane
26. Middle cerebral artery thrombosis: Acute blood-brain barrier consequences
27. Neuroprotective efficacy of ebselen, an anti-oxidant with anti-inflammatory actions, in a rodent model of permanent middle cerebral artery occlusion
28. Detection of hydroxyl radicals in rat striatum during transient focal cerebral ischemia: Possible implication in tissue damage
29. Alpha-phenyl-tert-butyl-nitrone reduces cortical infarct and edema in rats subjected to focal ischemia
30. Deoxycoformycin and oxypurinol: Protection against focal ischemic brain injury in the rat
31. Hydroxyl radical generation after the third hour following ischemia contributes to brain damage
32. A new hydroxyl radical scavenger: EPC-K1
33. Reduction of tissue plasminogen activator-induced hemorrhage and brain injury by free radical spin trapping after embolic focal cerebral ischemia in rats
34. Brown Memorial Lecture. Oxygen radicals in cerebral vascular injury