Cerebral hemorrhage due to heparin limits its neuroprotective effects: Studies in a rabbit model of photothrombotic middle cerebral artery occlusion

Brain Research

Volumn 902, Issue 1, 2001, Pages 30-39

  Zhao, Bing Qiao ^a   Suzuki, Yasuhiro ^a   Kondo, Kazunao ^a   Kawano, Ken Ichi ^a   Ikeda, Yasuhiko ^a   Umemura, Kazuo ^a  

^a HAMAMATSU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Antithromboti agents; Cerebral ischemia; Heprin; Intracerebal hemorrhage; Photothrombotic occlusion

Indexed keywords

ANTICOAGULANT AGENT; DRUG VEHICLE; HEPARIN; SODIUM CHLORIDE; THROMBOPLASTIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN HEMORRHAGE; BRAIN INFARCTION; BRAIN ISCHEMIA; CARDIOVASCULAR RISK; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; DRUG EFFECT; DRUG EFFICACY; DRUG MECHANISM; HEART INFARCTION SIZE; IRRADIATION; LIGHT DAMAGE; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; NEUROLOGIC DISEASE; NEUROPROTECTION; NONHUMAN; PARTIAL THROMBOPLASTIN TIME; PRIORITY JOURNAL; RABBIT; TREATMENT OUTCOME;

ANIMALS; CEREBRAL HEMORRHAGE; CEREBRAL INFARCTION; DOSE-RESPONSE RELATIONSHIP, DRUG; FIBRINOLYTIC AGENTS; HEPARIN; INFARCTION, MIDDLE CEREBRAL ARTERY; MALE; MODELS, ANIMAL; NEUROPROTECTIVE AGENTS; PARTIAL THROMBOPLASTIN TIME; RABBITS;

EID: 0035946986     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(01)02285-5     Document Type: Article

References (36)

1. Intracranial blood flow velocities in acute ischemic stroke
2. Antithrombotic and platelet activating effects of heparin in prevention of microarterial thrombosis
3. Intracerebral hemorrhage in stroke patients anticoagulated with heparin
4. Low-molecular weight heparins in venous and arterial thrombotic disease
5. Early anticoagulation after large cerebral embolic infarction: A safety study
6. Antithrombotic therapy for acute myocardial infarction: Mechanisms and prevention of deep venous, left ventricular, and coronary artery thromboembolism
7. Randomized, placebo-controlled trial of anticoagulant treatment with low-molecular-weight heparin for cerebral sinus thrombosis
8. Antithrombotic treatments in acute ischemic stroke
9. Recombinant tissue plasminogen activator in acute thrombotic and embolic stroke
10. Studies on the profibrinolytic actions of heparin and its fractions
11. Observations on brain embolism with special reference to the mechanism of hemorrhagic infarction
12. Hemorrhagic transformation and microvascular integrity during focal cerebral ischemia/reperfusion
13. Anticoagulant, thrombolytic, and antiplatelet drugs
14. ME3277, a GPIIb/IIIa antagonist reduces cerebral infarction without enhancing intracranial hemorrhage in photothrombotic occlusion of rabbit middle cerebral artery
15. Increased cerebral infarction by cyclic flow reductions: Studies in the guinea pig MCA thrombosis model
16. Superiority of platelet integrin GPIIb-IIIa receptor antagonist over aspirin in preventing cyclic flow reductions in the guinea pig middle cerebral artery
17. Effect of plasminogen activator (urokinase), plasmin, and thrombin on glycoprotein and collagenous components of basement membrane
18. Reversible middle cerebral artery occlusion without craniectomy in rats
19. Fatal ischemic brain edema after unsuccessful thrombolysis
20. Delayed increase in infarct volume after cerebral ischemia: Correlations with thrombolytic treatment and clinical outcome
21. Safety of anticoagulation after hemorrhagic infarction
22. Frequency of major complications of aspirin, warfarin, and intravenous heparin for secondary stroke prevention. A population-based study
23. An alternative view of heparin anticoagulation in acute focal brain ischemia
24. Hemorrhagic complications of thrombolytic therapy in experimental stroke
25. Hemorrhagic complications of thrombolytic therapy in experimental stroke
26. Focal cerebral ischemia in the rat. 1. Description of technique and early neuropathological consequences following middle cerebral artery occlusion
27. Detection of a new heparin-dependent inhibitor of thrombin in plasma
28. Evaluation of risk of hemorrhagic transformation in local intra-arterial thrombolysis in acute ischemic stroke by initial SPECT
29. Inhibitory effect of clopidogrel, vapiprost and argatroban in the middle cerebral artery thrombosis in the rat
30. 2 receptor antagonist, vapiprost in rat middle cerebral artery thrombosis model
31. High-dose heparin decreases nitric oxide production by cultured endothelial cells
32. Secondary reduction in the apparent diffusion coefficient of water, increase in cerebral blood volume, and delayed neuronal death after middle cerebral artery occlusion and early reperfusion in the rat
33. Dose arterial recanalization improve outcome in carotid territory stroke?
34. Induction of reproducible brain infarction by photochemically initiated thrombosis
35. Improved perfusion with rt-PA and hirulog in a rabbit model of embolic stroke
36. Factors determining the therapeutic window for stroke