Crystal structure of Fab198, an efficient protector of the acetylcholine receptor against myasthenogenic antibodies

European Journal of Biochemistry

Volumn 268, Issue 13, 2001, Pages 3685-3693

  Poulas, Konstantinos ^a   Eliopoulos, Elias ^b   Vatzaki, Efstratia ^a   Navaza, Jorge ^c   Kontou, Maria ^a   Oikonomakos, Nikos ^d   Ravi Acharya, K ^e   Tzartos, Socrates J ^a  

^a HELLENIC PASTEUR INSTITUTE   (Greece)

^b AGRICULTURAL UNIVERSITY OF ATHENS   (Greece)

^c Laboratoire de Genetique des Virus   (France)

^d INSTITUTE OF BIOLOGY   (Greece)

^e University of Bath   (United Kingdom)

Author keywords

Acetylcholine receptor; Antibody structure; Myasthenia gravis; X ray crystallography

Indexed keywords

CHOLINERGIC RECEPTOR; CHOLINERGIC RECEPTOR ANTIBODY; IMMUNOGLOBULIN F(AB) FRAGMENT 198; IMMUNOGLOBULIN F(AB) FRAGMENT D1 3; MONOCLONAL ANTIBODY; UNCLASSIFIED DRUG;

ALPHA CHAIN; ANALYTIC METHOD; ANIMAL CELL; ANTIBODY STRUCTURE; ANTIGEN BINDING; ARTICLE; AUTOIMMUNE DISEASE; BINDING SITE; COMPLEMENTARITY DETERMINING REGION; COMPUTER PROGRAM; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG ACTIVITY; DRUG DESIGN; MODEL; MUTANT; MYASTHENIA GRAVIS; NONHUMAN; PRIORITY JOURNAL; RAT; STRUCTURE ANALYSIS;

AMINO ACID SEQUENCE; ANIMALS; ANTIBODIES, MONOCLONAL; AUTOANTIBODIES; BINDING SITES, ANTIBODY; COMPUTER SIMULATION; CRYSTALLOGRAPHY, X-RAY; HUMANS; IMMUNOGLOBULIN FAB FRAGMENTS; MICE; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MURAMIDASE; MUSCLE, SKELETAL; MYASTHENIA GRAVIS; PROTEIN CONFORMATION; PROTEIN FOLDING; PROTEIN STRUCTURE, SECONDARY; RATS; RECEPTORS, NICOTINIC; SOFTWARE;

EID: 0034826222     PISSN: 00142956     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1432-1327.2001.02274.x     Document Type: Article

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