The third-dimensional structure of the complex between an Fv antibody fragment and an analogue of the main immunogenic region of the acetylcholine receptor: A combined two-dimensional NMR, homology, and molecular modeling approach

Biopolymers

Volumn 53, Issue 2, 2000, Pages 113-128

  Kleinjung, Jens ^a,d   Petit, Marie Christine ^a   Orlewski, Piotr ^a   Mamalaki, Avgi ^b   Tzartos, Socrates J ^b   Tsikaris, Vassilios ^c   Sakarellos Daitsiotis, Maria ^c   Sakarellos, Constantinos ^c   Marraud, Michel ^a   Cung, Manh Thong ^a  

^a LAB DE CHIM PHYS MACROMOLECULAIRE   (France)

^b HELLENIC PASTEUR INSTITUTE   (Greece)

^c UNIVERSITY OF IOANNINA   (Greece)

^d NATIONAL INSTITUTE FOR MEDICAL RESEARCH   (United Kingdom)

Author keywords

Anti acetylcholine receptor single chain Fv antibody; Docking; Homology modeling; Molecular dynamics; Myasthenia gravis; Protein structure prediction; Transferred nuclear Overhauser effect spectroscopy

Indexed keywords

AUTOANTIBODY; CHOLINERGIC RECEPTOR; DOCKING PROTEIN; EPITOPE;

ANTIBODY STRUCTURE; ANTIGEN ANTIBODY COMPLEX; ANTIGEN BINDING; ARTICLE; BINDING AFFINITY; IMMUNOGENICITY; MOLECULAR MODEL; MYASTHENIA GRAVIS; NUCLEAR MAGNETIC RESONANCE; NUCLEAR OVERHAUSER EFFECT; PREDICTION; PROTEIN STRUCTURE; SYSTEM ANALYSIS;

EID: 0033963862     PISSN: 00063525     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0282(200002)53:2<113::AID-BIP1>3.0.CO;2-J     Document Type: Article

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