Suppression of C8161 melanoma metastatic ability by chromosome 6 induces differentiation-associated tyrosinase and decreases proliferation on adhesion-restrictive substrates mediated by overexpression of p21WAF1 and down-regulation of bcl-2 and cyclin D3

Biochemical and Biophysical Research Communications

Volumn 281, Issue 1, 2001, Pages 159-165

  Strasberg Rieber, Mary ^a   Welch, Danny R ^b   Rieber, Manuel ^a  

^a INSTITUTO VENEZOLANO DE INVESTIGACIONES CIENTÍFICAS   (Venezuela)

^b PENN STATE CANCER INSTITUTE   (United States)

Author keywords

Differentiation; Growth control; Invasion associated MMP 9 gelatinase; Metastasis suppression

Indexed keywords

CYCLIN D3; GELATINASE B; MONOPHENOL MONOOXYGENASE; PROTEIN BCL 2; PROTEIN P21;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CANCER INVASION; CELL DIFFERENTIATION; CELL PROLIFERATION; CHROMOSOME 6; CONTROLLED STUDY; DOWN REGULATION; ENZYME SUBSTRATE; GENE ACTIVATION; GENE EXPRESSION REGULATION; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; MELANOMA; METASTASIS INHIBITION; MOUSE; NONHUMAN; PRIORITY JOURNAL;

EID: 0034816015     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1006/bbrc.2001.4330     Document Type: Article

References (19)

1. Differential gene expression associated with suppression of melanoma cell spreading and proliferation on adhesion-restrictive substrates
2. Integrins and anoikis
3. Fibronectin suppresses apoptosis in normal human melanocytes through an integrin-dependent mechanism
4. Microcell-mediated transfer of chromosome 6 into metastatic human C8161 melanoma cells suppresses metastasis but does not inhibit tumorigenicity
5. Is p21WAF1 a Suppressor of malignant melanoma metastasis?
6. Detection of amplification of a chromosomal fragment at 6p21 including the cyclin D3 gene in a glioblastoma cell line by arbitrarily primed PCR
7. Specific tyrosinases associated with melanoma replicative senescence and melano-genesis
8. The 92-kDa gelatinase B is expressed by advanced stage melanoma cells: Suppression by somatic cell hybridization with early stage melanoma cells
9. Induction of p53 without increase in p21WAF1 in betulinic acid-mediated cell death is preferential for human metastatic melanoma
10. WAF1 and reciprocal down-regulation of cyclin A and proliferating cell nuclear antigen in bromodeoxyuridine-mediated growth arrest of human melanoma cells
11. Ordering of ceramide formation, caspase activation, and Bax/Bcl-2 expression during etoposide-induced apoptosis in C6 glioma cells
12. 125I-5-iodo-2′-deoxyuridine
13. Fate of melanoma cells entering the microcirculation: Over 80% survive and extravasate
14. Apoptosis induced by inhibition of intercellular contact
15. Cell-contact and -architecture of malignant cells and their relationship to metastasis
16. Technical considerations for studying cancer metastasis in vivo
17. p21WAF1/Cip1 acts in synergy with bcl-2 to confer multidrugresistance in a camptothecin-selected human lung cancer cell line
18. Induction of p21WAF1/Cip1 during differentiation
19. Cyclin D3: Requirement for G1/S transition and high abundance in quiescent tissues suggest a dual role in proliferation and differentiation