Topical synthetic inhibitor of matrix metalloproteinases delays epidermal regeneration of human wounds

Experimental Dermatology

Volumn 10, Issue 5, 2001, Pages 337-348

  Ågren, Magnus S ^a,b   Mirastschijski, U ^c   Karlsmark, T ^b   Saarialho Kere, U K ^d  

^a Aagren Dermaconsulting ApS   (Denmark)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

^c LUND UNIVERSITY HOSPITAL   (Sweden)

^d UNIVERSITY OF HELSINKI   (Finland)

Author keywords

Basement membrane; Collagenase; Gelatinase; Proteases; Wound repair

Indexed keywords

DRUG VEHICLE; GELATINASE A; GELATINASE B; ILOMASTAT; INTERSTITIAL COLLAGENASE; KALININ; MATRIX METALLOPROTEINASE; MATRIX METALLOPROTEINASE INHIBITOR; PROTEIN;

ADULT; ARTICLE; BLISTER; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DISEASE ASSOCIATION; DRUG ACTIVITY; DRUG INHIBITION; ENZYME ACTIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; EPIDERMIS; EPITHELIZATION; EXTRACELLULAR MATRIX; FOREARM; HUMAN; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; MALE; MICROSCOPY; PROTEIN EXPRESSION; PROTEIN SYNTHESIS; SKIN WATER LOSS; STRATUM CORNEUM; WOUND; WOUND HEALING; ZYMOGRAPHY;

ADULT; BLISTER; CELL ADHESION MOLECULES; DIPEPTIDES; ENZYME INHIBITORS; EPIDERMIS; HUMANS; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; MALE; MATRIX METALLOPROTEINASE 1; MATRIX METALLOPROTEINASE 2; MATRIX METALLOPROTEINASE 9; MATRIX METALLOPROTEINASES; MIDDLE AGED; REGENERATION; SUCTION; TIME FACTORS; WOUND HEALING;

EID: 0034814434     PISSN: 09066705     EISSN: None     Source Type: Journal    
DOI: 10.1034/j.1600-0625.2001.100506.x     Document Type: Article

References (46)

1. Matrix metalloproteinases
2. Collagenase in wound healing: Effect of wound age and type
3. Demonstration of 72-kDa and 92-kDa forms of type IV collagenase in human skin: Variable expression in various blistering diseases, induction during re-epithelialization, and decrease by topical glucocorticoids
4. Matrix metalloproteinases in repair
5. Matrix metalloproteinases (MMPs) and their physiological inhibitors (TIMPs) are differentially expressed during excisional skin wound repair
6. Age-related differences in the temporal and spatial regulation of matrix metalloproteinases (MMPs) in normal skin and acute cutaneous wounds of healthy humans
7. Matrix metalloproteinases in skin
8. Distinct localization of collagenase and tissue inhibitor of metalloproteinases expression in wound healing associated with ulcerative pyogenic granuloma
9. Cell-matrix interactions modulate interstitial collagenase expression by human keratinocytes actively involved in wound healing
10. Expression of matrix metalloproteinase-2 and -9 during early human wound healing
11. Patterns of matrix metalloproteinase and TIMP-1 expression in chronic and normally healing human cutaneous wounds
12. Stromelysin-2 is upregulated during normal wound repair and is induced by cytokines
13. Causes and effects of the chronic inflammation in venous leg ulcers
14. Functional overlap between two classes of matrix-degrading proteases in wound healing
15. Matrix metalloproteinases (MMPs) are required for re-epithelialization of cutaneous wounds
16. Suction blisters in the study of cellular dynamics of inflammation
17. Basal lamina components in experimentally induced skin blisters
18. Interstitial collagenase is expressed by keratinocytes that are actively involved in reepithelialization in blistering skin disease
19. Validation of an in vivo wound healing model for the quantification of pharmacological effects on epidermal regeneration
20. Laminin-5 expression is independent of the injury and the micro-environment during reepithelialization of wounds
21. Induction of cell migration by matrix metalloprotease-2 cleavage of laminin-5
22. Study of the stratum corneum barrier function by transepidermal water loss measurements: Comparison between two commercial instruments: Evaporimeter® and Tewameter®
23. Distinct populations of basal keratinocytes express stromelysin-1 and stromelysin-2 in chronic wounds
24. Human TIMP-3 is expressed during fetal development, hair growth cycle, and cancer progression
25. Regional heterogeneity of elastin and collagen gene expression in intralobar arteries in response to hypoxic pulmonary hypertension as demonstrated by in situ hybridization
26. Enhanced expression of human metalloelastase (MMP-12) in cutaneous granulomas and macrophage migration
27. Human collagenase-3 is expressed in malignant squamous epithelium of the skin
28. Direct extraction and assay of bone tissue collagenase and its relation to parathyroid-hormone-induced bone resorption
29. Quantitative zymography: Detection of picogram quantities of gelatinases
30. Influence of aging, localization, glucocorticoids and isotretinoin on matrix metalloproteases 2 (MMP-2) and 9 (MMP-9) in suction blister fluids
31. Effects of occlusive and semiocclusive dressings on the return of barrier function to transepidermal water loss in standardized human wounds
32. A model for studies of dermal surface epithelization: With observations on the effects of dexamethasone and nandrolone decanoate
33. Matrix metalloproteinase 2 (gelatinase A) is related to migration of keratinocytes
34. Differential regulation of MMP-2 and MMP-9 gelatinases in cultured human keratinocytes
35. Aberrant integrin expression during epidermal wound healing and in psoriatic epidermis
36. Re-epithelialization rate and protein expression in the suction-induced wound model: Comparison between intact blisters, open wounds and calcipotriol-pretreated open wounds
37. Keratinocyte conditioned medium stimulates type IV collagenase synthesis in cultured human keratinocytes and fibroblasts
38. Direct evidence for spatial and temporal regulation of transforming growth factor β1 during cutaneous wound healing
39. Collagen-stimulated induction of keratinocyte collagenase is mediated via tyrosine kinase and protein kinase C activities
40. Dynamics of the cellular and humoral components of the inflammatory response elicited in skin blisters in humans
41. A metalloproteinase inhibitor blocks the shedding of soluble cytokine receptors and processing of transmembrane cytokine precursors in human monocytic cells
42. Matrix metalloproteinase 9 level predicts optimal collagen deposition during early wound repair in humans
43. Migration of neutrophils across human pulmonary endothelial cells is not blocked by matrix metalloproteinase or serine protease inhibitors
44. Differential expression of tissue inhibitors of metalloproteinases (TIMP-1, -2, -3, and -4) in normal and aberrant wound healing
45. Measurement of transepidermal water loss using an evaporimeter to follow the restitution of the barrier layer of human epidermis after stripping the stratum corneum
46. Stratum corneum thiol protease (SCTP): A novel cysteine protease of late epidermal differentiation