Downregulation of the cdc2/cyclin B protein kinase activity by binding of p53 to p34cdc2

Biochemical and Biophysical Research Communications

Volumn 283, Issue 2, 2001, Pages 507-512

  Ababneh, Muhannad ^a   Götz, Claudia ^a   Montenarh, Mathias ^a  

^a SAARLAND UNIVERSITY   (Germany)

Author keywords

Cyclin dependent kinase p34cdc2; Growth suppressor protein; P53; Phosphorylation; Protein protein interaction

Indexed keywords

CYCLIN B1; HISTONE H1; PROTAMINE KINASE; PROTEIN KINASE; PROTEIN P53;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; BINDING SITE; CARBOXY TERMINAL SEQUENCE; CELL CYCLE; DOWN REGULATION; ENZYME ACTIVITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; TRANSACTIVATION;

EID: 0034811668     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1006/bbrc.2001.4792     Document Type: Article

References (38)

1. Cell-cycle control in mammalian cells: Role of cyclins, cyclin dependent kinases (CDKs), growth suppressor genes, and cyclin-dependent kinase inhibitors (CKIs)
2. Cyclins and cell-cycle checkpoints
3. p21-Negative regulator of the cell cycle
4. WAF1
5. Cell-cycle control, checkpoint mechanisms, and genotoxic stress
6. Introduction: p53 - The first twenty years
7. The p53 pathway
8. Deciphering the mammalian stress response - A stressful task
9. p21/p53, cellular growth control and genomic integrity
10. Human p53 is phosphorylated by p60-cdc2 and cyclin B-cdc2
11. Increased and altered DNA binding of human p53 by S and G2/M but not G1 cyclin-dependent kinases
12. The human Cdc14 phosphatases interact with and dephosphorylate the tumor suppressor protein p53
13. 14-3-3Sigma is required to prevent mitotic catastrophe after DNA damage
14. Association with Cdc2 and inhibition of Cdc2/cyclin B1 kinase activity by the p53-regulated protein Gadd45
15. p53 regulates a G2 checkpoint through cyclin B1
16. p53 negatively regulates cdc2 transcription via the CCAAT-binding NF-Y transcription factor
17. cdc2 in mammalian cells: Implications for cell-cycle control and oncogenesis
18. cdc2 in transformed cells
19. Fine mapping and regulation of the association of p53 and p34cdc2
20. Protein kinase CK2 binds to a multi-protein binding domain of the growth suppressor protein p53
21. The in vitro phosphorylation of p53 by calcium-dependent protein kinase C - Characterization of a protein-kinase-C-binding site on p53
22. Phosphorylation mutants of p53 show differential complex formation with putative dehydrogenase Tms1 of fission yeast
23. Cleavage of structural proteins during the assembly of the head of bacteriophage T 4
24. Wild-type p53 inhibits protein kinase CK2 activity
25. cdc2 reversible growth arrest in fission yeast
26. 2-M arrest
27. CDC2 is down-regulated by ionizing radiation in a p53-dependent manner
28. The tumour suppressor protein p53 can repress transcription of cyclin B
29. Waf1
30. Does the p53 up-regulated Gadd45 protein have a role in excision repair
31. Gadd45, a p53-responsive stress protein, modifies DNA accessibility on damaged chromatin
32. WAF1, a potential mediator of p53 tumor suppression
33. Regulation of CAK kinase activity by p53
34. 7-cycH-p36 complex of transcription factor IIH phosphorylates p53, enhancing its sequence-specific DNA binding activity in vitro
35. MAT1- dependent manner
36. Binding of the growth suppressor p53 protein to the cell-cycle regulator phosphatase cdc25C
37. The carboxy terminus of p53 mimicks the polylysine effect of protein kinase CK2-catalyzed MDM2 phosphorylation
38. Identification of a minimal transforming domain of p53: Negative dominance through abrogation of sequence-specific DNA binding