Stimulation of DNA polymerase α activity by Cdk2-phosphorylated Rb protein

Biochemical and Biophysical Research Communications

Volumn 282, Issue 4, 2001, Pages 984-990

  Takemura, Masaharu ^a   Yamamoto, Takashi ^a   Kitagawa, Masatoshi ^b   Taya, Yoichi ^c   Akiyama, Tetsu ^d   Asahara, Hitomi ^e   Linn, Stuart ^e   Suzuki, Susumu ^f   Tamai, Katsuyuki ^f   Yoshida, Shonen ^a  

^a NAGOYA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b HAMAMATSU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^c NATIONAL CANCER CENTER RESEARCH INSTITUTE   (Japan)

^d UNIVERSITY OF TOKYO   (Japan)

^e UNIVERSITY OF CALIFORNIA   (United States)

^f Medical & Biological Laboratories Co Ltd   (Japan)

Author keywords

Cdk2; Cdk4; Cell cycle; DNA polymerase ; DNA polymerase ; DNA polymerase ; Phosphorylation; Rb; Retinoblastoma; Stimulation

Indexed keywords

CYCLIN DEPENDENT KINASE 2; DNA DIRECTED DNA POLYMERASE ALPHA; RETINOBLASTOMA PROTEIN;

ANIMAL CELL; ARTICLE; CELL CYCLE G1 PHASE; CELL CYCLE S PHASE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME INACTIVATION; ENZYME STABILITY; ENZYME SUBUNIT; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION;

EID: 0034809483     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1006/bbrc.2001.4675     Document Type: Article

References (36)

1. Eukaryotic DNA polymerases
2. Cell cycle control of DNA replication
3. Putting it all together: Building a prereplicating complex
4. The DNA replication fork in eukaryotic cells
5. The regulation of E2F by pRb-family proteins
6. Role of the Rb/E2F pathway in cell growth control
7. Cancer cell cycles
8. The retinoblastoma protein and cell cycle control
9. Kip1
10. Expression of NPAT, a novel substrate of cyclin E-CDK2, promotes S-phase entry
11. Activity of RNA polymerase I transcription factor UBF blocked by Rb gene product
12. Mechanistic analysis of RNA polymerase III regulation by the retinoblastoma protein
13. Retinoblastoma protein recruits histone deacetylase to repress transcription
14. Retinoblastoma protein represses transcription by recruiting a histone deacetylase
15. Nucleolar protein B23.1 binds to retinoblastoma protein and synergistically stimulates DNA polymerase α activity
16. The consensus motif for phosphorylation by cyclin D 1-cdk4 is different from that for phosphorylation by cyclin A/E-cdk2
17. Poly(ADP-ribose) polymerase stimulates DNA polymerase α by physical association
18. Structural study of immunoaffinity-purified DNA polymerase α-DNA primase complex from calf thymus
19. Phosphorylated retinoblastoma protein stimulates DNA polymerase α
20. DNA replication in vitro by recombinant DNA-polymerase-α-primase
21. Purification of mammalian polymerases: DNA polymerase epsilon
22. Expression of the human retinoblastoma gene product pp110RB in insect cells using the baculovirus system
23. Phosphorylation of the retinoblastoma protein by cdk2
24. Efficient purification of a full length and biochemically active p110Rb, the retinoblastoma gene product
25. Multiple molecular species of cytoplasmic DNA polymerase from calf thymus
26. Selective inhibition of DNA polymerase ε by phosphatidylinositol
27. RNA priming coupled with DNA synthesis on natural template by calf thymus DNA polymerase α-primase
28. Functional inactivation of the retinoblastoma protein requires sequential modification by at least two distinct cyclin-cdk complexes
29. Calf thymus Hsc70 protein protects and reactivates prokaryotic and eukaryotic enzymes
30. Phosphorylation of the retinoblastoma gene product is modulated during the cell cycle and cellular differentiation
31. Differential regulation of retinoblastoma protein function by specific cdk phosphorylation sites
32. Dual mechanisms for the inhibition of E2F binding to RB by cyclin-dependent kinase-mediated RB phosphorylation
33. Cdk phosphorylation triggers sequential intramolecular interactions that progressively block Rb functions as cells move through G1
34. S-phase entry upon ectopic expression of G1 cyclin-dependent kinases in the absence of retinoblastoma protein phosphorylation
35. Cyclin E-induced S phase without activation of the pRb/E2F pathway
36. Cleavage of structural proteins during the assembly of the head of the bacteriophage T4