Fructose-2,6-bisphosphate, a potent stimulator of phosphofructokinase, is increased by high exogenous glucose perfusion

Coronary Artery Disease

Volumn 11, Issue 3, 2000, Pages 279-286

  Salaris, Steven C ^a   Ramasamy, Ravichandran ^b   Bergmann, Steven R ^a,b  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b The New York Presbyterian Hospital   (United States)

Author keywords

Cardiac glycolysis; Cardioprotection; Fructose 2,6 bisphosphate; Glucose; Ischemia; Metabolism

Indexed keywords

6 PHOSPHOFRUCTOKINASE; FRUCTOSE 2,6 BISPHOSPHATE; GLUCOSE; INSULIN; LACTIC ACID; PALMITIC ACID;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; GLUCOSE TRANSPORT; GLYCOLYSIS; HEART MUSCLE ISCHEMIA; HEART PERFUSION; ISOLATED HEART; NONHUMAN; PRIORITY JOURNAL; RABBIT;

ADENOSINE TRIPHOSPHATE; ANIMALS; GLUCOSE; GLYCOGEN; GLYCOLYSIS; HEMODYNAMIC PROCESSES; LACTIC ACID; MYOCARDIAL ISCHEMIA; PHOSPHOFRUCTOKINASE-1; PHOSPHOFRUCTOKINASE-2; PHOSPHORIC MONOESTER HYDROLASES; RABBITS;

EID: 0034031719     PISSN: 09546928     EISSN: None     Source Type: Journal    
DOI: 10.1097/00019501-200005000-00012     Document Type: Article

References (31)

1. 1. Fath-Ordoubadi F, Beatt KJ. Glucose-insulin-potassium therapy for treatment of acute myocardial infarction. An overview of randomized placebo-controlled trials. Circulation 1997; 96:1152-1156.
2. 2. Diaz F, Paolasso EA, Piegas LS, Tajer CD, Moreno MG, Corvalan R, et al. Metabolic modulation of acute myocardial infarction. The ECLA (Estudios Cardiologicos Latinoamerica) Collaborative group. Circulation 1998; 98:2227-2234.
3. 3. Vanoverschelde J-LJ, Janier MF, Bakke JE, Marshall DR, Bergmann SR. Rate of glycolysis during ischemia determines extent of ischemic injury and functional recovery after reperfusion. Am J Physiol 1994; 267:H1785-H1794.
4. 4. Vanoverschelde J-LJ, Janier MF, Bergmann SR. The relative importance of myocardial energy metabolism compared with ischemic contracture in the determination of ischemic injury in isolated rabbit hearts. Circ Res 1994; 74:817-828.
5. 5. Ramasamy R, Trueblood NA, Schaefer S. Metabolic effects of aldose reductase inhibition during low-flow ischemia and reperfusion. Am J Physiol - Heart Circ Physiol 1998; 275:H195-H203.
6. 6. Stanley WC, Lopaschuk GD, Hall JL, McCormack JG. Regulation of myocardial carbohydrate metabolism under normal and ischemic conditions. Potential for pharmacological interventions. Cardiovasc Res 1997; 33:243-257.
7. 7. King LM, Opie LH. Glucose and glycogen utilization in myocardial ischemia - changes in metabolism and consequences for the myocyte. Mol Cell Biochem 1998; 180:3-26.
8. 8. Sun D, Nguyen N, DeGrado TR, Schwaiger M, Brosius FC. Ischemia induces translocation of the insulin-responsive glucose transporter GLUT-4 to the plasma membrane of cardiac myocytes. Circulation 1994; 89:793-798.
9. 9. Young LH, Renfu Y, Russell R, Hu X, Caplan M, Ren J, et al. Low-flow ischemia leads to translocation of canine heart GLUT-4 and GLUT-1 transporters to the sarcolemma in vivo. Circulation 1997; 95:415-422.
10. 10. Opie LH, Bruyneel K, Owen P. Effects of glucose, insulin and potassium infusion on tissue metabolic changes within the first hour of myocardial infarction in the baboon. Circulation 1975; 52:49-57.
11. 11. Neely JR, Morgan HE. Relationship between carbohydrate and lipid metabolism and the energy balance of heart muscle. Ann Rev Physiol 1974; 36:413-459.
12. 12. Liedtke AJ. Alterations of carbohydrate and lipid metabolism in the acutely ischemic heart. Prog Cardiovasc Dis 1981; 23:321-336.
13. 13. Lawson JWR, Uyeda K. Effects of insulin and work on fructose 2,6-bisphosphate content and phosphofructokinase activity in perfused rat hearts. J Biol Chem 1987; 262:3165-3173.
14. 14. Hue L, Depre C, Lefebvre V, Rider MH, Veitch K. Regulation of glucose metabolism in cardiac muscle. Biochem Soc Trans 1995; 23:311-314.
15. 15. Hue L, Rider MH. Role of fructose 2,6-bisphosphate in the control of glycolysis in mammalian tissues. Biochem J 1987; 245:313-324.
16. 16. Kornberg A, Horecker BL. Glucose-6-phosphate dehydrogenase. Methods Enzymol 1955; 1:323-327.
17. 17. Bergmeyer HU, Bergmeyer J, Graßl M. Carbohydrates. In: Methods of enzymatic analysis. 3rd ed. Volume VI. Metabolites 1: carbohydrates. Deerfield Beach: Verlag Chemie; 1995. pp. 570-587.
18. 18. Carr RS, Neff JM. Quantitative semi-automated enzymatic assay for tissue glycogen. Comp Biochem Physiol 1984; 77B:447-449.
19. 19. Sellevold OFM, Jynge P, Aarstad K. High performance liquid chromatography: a rapid isocratic method for determination of creatine compound and adenine nucleotides in myocardial tissue. J Mol Cell Cardiol 1986; 18:517-527.
20. 2+], elevation and ATP depletion. Am J Physiol 1990; 258:H9-H16.
21. 21. Apstein CS, Gravino FN, Haudenschild CC. Determinants of a protective effect of glucose and insulin on the ischemic myocardium. Circ Res 1983; 52:515-526.
22. 22. Owen P, Dennis S, Opie LH. Glucose flux rate regulates onset of ischemic contracture in globally underperfused rat hearts. Circ Res 1990; 66:344-354.
23. 23. Opie LH, Owen P. Effect of glucose-insulin-potassium infusions on arteriovenous differences of glucose and free fatty acids and on tissue metabolic changes in dogs with developing myocardial infarction. Am J Cardiol 1976; 38:310-321.
24. 24. Stanley AW, Moraski RE, Russell RO, Rogers WJ, Mantle JA, Kreisberg RA, et al. Effects of glucose-insulin-potassium on myocardial substrate availability and utilization in stable coronary artery disease. Am J Cardiol 1975; 36:929-937.
25. 25. Schaefer S, Prussel E, Carr U. Requirement of glycolytic substrate for metabolic recovery during moderate low flow ischemia. J Mol Cell Cardiol 1995; 27:2167-2176.
26. 87Rb NMR spectroscopic study. Magn Reson Med 1995; 34:673 -685.
27. + loss and cardiac function in ischemic and reperfused mammalian ventricle. Circ Res 1992; 71:1324-1333.
28. 28. Weiss J, Hiltbrand B. Functional compartmentation of glycolytic versus oxidative metabolism in isolated rabbit heart. J Clin Invest 1985; 75:436-447.
29. 2+ overload and depressed recovery of ventricular function of reperfused ischemic rat hearts. Circ Res 1989; 65:1045-1056.
30. 2+ overload and impairs function in anoxic rat heart. J Mol Cell Cardiol 1990; 22:57-72.
31. 31. Jermey RW, Koretsune Y, Marban E, Becker LC. Relationship between glycolysis and calcium homeostasis in postischemic myocardium. Circ Res 1992; 70:1180-1190.