Prenatal ionizing radiation-induced apoptosis of the developing murine brain with special references to the expression of some proteins

Kobe Journal of Medical Sciences

Volumn 47, Issue 2, 2001, Pages 59-76

  Kitamura, Makiko ^a   Itoh, Kyoko ^a   Matsumoto, Akira ^a   Hayashi, Yoshitake ^a   Sasaki, Ryohei ^a   Imai, Yukihiro ^a   Itoh, Hiroshi ^a  

^a KOBE UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Apoptosis; Developing brain; Ionizing radiation

Indexed keywords

CASPASE 3; DNA FRAGMENT; PROTEIN BAX; PROTEIN BCL X;

ANIMAL TISSUE; APOPTOSIS; ARTICLE; BODY WEIGHT; BRAIN CORTEX; BRAIN DEVELOPMENT; BRAIN WEIGHT; CONTROLLED STUDY; FETUS; IONIZING RADIATION; MICROCEPHALY; MOUSE; NEWBORN; NICK END LABELING; NONHUMAN; PRENATAL EXPOSURE; PROTEIN EXPRESSION; RADIATION EXPOSURE; RADIATION INJURY;

ANIMALS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; BCL-X PROTEIN; BLOTTING, WESTERN; BRAIN; CASPASE 3; CASPASES; DNA FRAGMENTATION; FEMALE; FLUORESCENT ANTIBODY TECHNIQUE; GENE EXPRESSION; GESTATIONAL AGE; IMMUNOHISTOCHEMISTRY; IN SITU NICK-END LABELING; KINETICS; MICE; MICE, INBRED C57BL; MICROCEPHALY; MICROSCOPY, ELECTRON; ORGAN SIZE; PREGNANCY; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-2;

EID: 0034799151     PISSN: 00232513     EISSN: 18830498     Source Type: Journal    
DOI: None     Document Type: Article

References (19)

1. Gamma radiation-induced cell death in the fetal rat brain possesses molecular characteristics of apoptosis and is associated with specific messenger RNA elevations
2. Bax is required for neuronal death after trophic factor deprivation and during development
3. Response of postmitotic neurons to X-irradiation: Implications for the role of DNA damage in neuronal apoptosis
4. Bcl-x is expressed in embryonic and postnatal neural tissues and functions to prevent neuronal cell death
5. Role of bcl-2 in the survival and function of developing and mature sympathetic neurons
6. Prenatal irradiation: A major concern for the developing brain
7. Bax-deficient mice with lymphoid hyperplasia and male germ cell death
8. Chkl is an essential kinase that is regulated by Atr and required for the G2/M DNA damage checkpoint
9. Massive cell death of immature hematopoietic cells and neurons in Bcl-x-deficient mice
10. Targeted disruption of Bcl-2 α β in mice: Occurrence of gray hair, polycystic kidney disease, and lymphocytopenia
11. Bcl-xL is an antiapoptotic regulator for postnatal CNS neurons
12. Double identity for proteins of the Bcl-2 family
13. Target cells of apoptosis in the adult murine dentate gyrus and 04 immunoreactivity after ionizing radiation
14. Multiple Bcl-2 family members demonstrate selective dimerizations with Bax
15. An immunohistochemical study of radial glial cells in the mouse brain prenatally exposed to γ-irradiation
16. Follow-up study on histogenesis of microcephaly associated with ectopic gray matter induced by prenatal γ-irradiation in the mouse
17. Aberrant cell cycle checkpoint function and early embryonic death in Chkl-/- mice
18. Bcl-2-deficient mice demonstrate fulminant lymphoid apoptosis, polycystic kidneys, and hypopigmented hair
19. Widespread elimination of naturally occurring neuronal death in Bax-deficient mice