Splicing factor SRP20 is a novel partner of BCL6 in a t(3;6)(q27;p21) translocation in transformed follicular lymphoma

Genes Chromosomes and Cancer

Volumn 32, Issue 3, 2001, Pages 281-284

  Chen, Weiyi ^a   Itoyama, Takahiro ^a   Chaganti, R S K ^a  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN BCL 6; PROTEIN SRP20; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG; ZINC FINGER PROTEIN;

ADULT; ARTICLE; B LYMPHOCYTE; CASE REPORT; CHROMOSOME 3Q; CHROMOSOME TRANSLOCATION 3; FOLLICULAR LYMPHOMA; GENE CONTROL; GENE MAPPING; HISTOLOGY; HUMAN; HUMAN CELL; MALE; NONHODGKIN LYMPHOMA; NORTHERN BLOTTING; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROMOTER REGION; RNA SPLICING;

BASE SEQUENCE; CELL TRANSFORMATION, NEOPLASTIC; CHROMOSOMES, HUMAN, PAIR 3; CHROMOSOMES, HUMAN, PAIR 6; DNA-BINDING PROTEINS; HUMANS; LYMPHOMA, FOLLICULAR; MALE; MIDDLE AGED; MOLECULAR SEQUENCE DATA; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-6; RESTRICTION MAPPING; RNA SPLICING; RNA-BINDING PROTEINS; TRANSCRIPTION FACTORS; TRANSLOCATION, GENETIC;

EID: 0034797156     PISSN: 10452257     EISSN: None     Source Type: Journal    
DOI: 10.1002/gcc.1191     Document Type: Article

References (20)

1. A recurring translocation, t(3;6)(q27;p21), in non-Hodgkin's lymphoma results in replacement of the 5′ regulatory region of BCL6 with a novel H4 histone gene
2. High incidence of chromosomal imbalances and gene amplifications in the classical follicular variant of follicle center lymphoma
3. Involvement of BCL6 in chromosomal aberrations affecting band 3q27 in B-cell non-Hodgkin lymphoma
4. Heterologous promoters fused to BCL6 by chromosomal translocations affecting band 3q27 cause its deregulated expression during B-cell differentiation
5. Molecular pathogenesis of B cell malignancy: The role of BCL-6
6. TTF, a gene encoding a novel small G protein, fuses to the lymphoma-associated LAZ3 gene by t(3;4) chromosomal translocation
7. Control of inflammation, cytokine expression, and germinal center formation by BCL-6
8. Fusion of the LAZ3/BCL6 and BOB1/OBF1 genes by t(3;11) (q27;q23). Chromosomal translocation
9. Nonrandom fusion of L-plastin(LCP1) and LAZ3(BCL6) genes by t(3;13)(q27;q14) chromosome translocation in two cases of B-cell non-Hodgkin lymphoma
10. The Ikaros gene, a central regulator of lymphoid differentiation, fuses to the BCL6 gene as a result of t(3;7)(q27;p12) translocation in a patient with diffuse large B-cell lymphoma
11. Regulation of SRp20 exon 4 splicing
12. Regulated expression and RNA processing of transcripts from the Srp20 splicing factor gene during the cell cycle
13. Identification and mapping of novel tumor suppressor loci on 6p in diffuse large B-cell non-Hodgkin's lymphoma
14. BCL-6 represses genes that function in lymphocyte differentiation, inflammation, and cell cycle control
15. Stage-specific changes in SR splicing factors and alternative splicing in mammary tumorigenesis
16. Alternative splicing of CD45 pre-mRNA is uniquely obedient to conditions in lymphoid cells
17. Fluorescence in situ hybridization identifies new chromosomal changes involving 3q27 in non-Hodgkin's lymphomas with BCL6/LAZ3 rearrangement
18. Cloning of bcl-6, the locus involved in chromosome translocations affecting band 3q27 in B-cell lymphoma
19. Chromosomal translocations cause deregulated BCL6 expression by promoter substitution in B cell lymphoma
20. The BCL-6 proro-oncogene controls germinal-centre formation and Th2-type inflammation