Use of hypoxia-regulated gene expression in tumor-specific gene therapy

Current Opinion in Investigational Drugs

Volumn 2, Issue 6, 2001, Pages 839-843

  Ruan, H ^a   Deen, D F ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Gene therapy; Hypoxia; Hypoxia inducible factor 1; Hypoxia responsive element; Tumor

Indexed keywords

5 (1 AZIRIDINYL) 2,4 DINITROBENZAMIDE; ANTINEOPLASTIC AGENT; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; ERYTHROPOIETIN; FAS LIGAND; FLUOROURACIL; GANCICLOVIR; HYPOXIA INDUCIBLE FACTOR 1; NITRIC OXIDE SYNTHASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN BAX; PROTEIN P16; PROTEIN P53; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND; VASCULOTROPIN; VIRUS VECTOR;

BRAIN TUMOR; CANCER CHEMOTHERAPY; CANCER INHIBITION; CANCER SURGERY; CELL KILLING; DNA RESPONSIVE ELEMENT; EXPRESSION VECTOR; GENE EXPRESSION REGULATION; GENE INDUCTION; GENE OVEREXPRESSION; GENE TARGETING; GENE THERAPY; GENETIC TRANSFECTION; HOMEOSTASIS; HUMAN; HYPOXIA; HYPOXIC CELL; NONHUMAN; OXYGEN TENSION; PATHOPHYSIOLOGY; REVIEW; SIGNAL TRANSDUCTION; SOLID TUMOR; SUICIDE GENE; TISSUE SPECIFICITY; TRANSCRIPTION INITIATION; TREATMENT OUTCOME; TUMOR RESISTANCE; TUMOR SUPPRESSOR GENE;

ANIMALS; ANOXIA; GENE EXPRESSION REGULATION; GENE THERAPY; HUMANS; NEOPLASMS; SIGNAL TRANSDUCTION;

EID: 0034795343     PISSN: 09678298     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

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