A MEK inhibitor, PD98059 enhances IL-1-induced NF-κB activation by the enhanced and sustained degradation of IκBα

Biochemical and Biophysical Research Communications

Volumn 283, Issue 1, 2001, Pages 248-254

  Funakoshi, Megumi ^a   Tago, Kenji ^b   Sonoda, Yoshiko ^a   Tominaga, Shin ichi ^b   Kasahara, Tadashi ^a  

^a KEIO UNIVERSITY   (Japan)

^b JICHI MEDICAL UNIVERSITY   (Japan)

Author keywords

ERK; Interleukin 1; I B ; MEK; NF B; PD98059; Proteasome

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; I KAPPA B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1; MITOGEN ACTIVATED PROTEIN KINASE; PROTEASOME; RAF PROTEIN;

ARTICLE; CELL LINE; CONTROLLED STUDY; DNA BINDING; ELECTROPHORETIC MOBILITY; ENZYME ACTIVATION; GENE EXPRESSION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION;

EID: 0034789898     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1006/bbrc.2001.4759     Document Type: Article

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